CA2289001A1 - Nouveaux composes heterocycliques - Google Patents

Nouveaux composes heterocycliques Download PDF

Info

Publication number
CA2289001A1
CA2289001A1 CA002289001A CA2289001A CA2289001A1 CA 2289001 A1 CA2289001 A1 CA 2289001A1 CA 002289001 A CA002289001 A CA 002289001A CA 2289001 A CA2289001 A CA 2289001A CA 2289001 A1 CA2289001 A1 CA 2289001A1
Authority
CA
Canada
Prior art keywords
hydroxymethyl
piperidinediol
compound according
alkyl
diabetes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002289001A
Other languages
English (en)
Inventor
Marit Kristiansen
Palle Jakobsen
Jane Marie Lundbeck
Birgitte Sokilde
Karsten Lundgren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/DK1998/000177 external-priority patent/WO1998050359A1/fr
Publication of CA2289001A1 publication Critical patent/CA2289001A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de pipéridine. Ces composés permettent de traiter et/ou de prévenir le diabète, et en particulier, le diabète non insulino-dépendant (NIDDM ou diabète de type 2). Ils sont également utiles dans le traitement de nuit ou au cours des repas, et le traitement ou la prévention de complications à long terme, comme la rétinopathie, la neuropathie, la néphropathie, et la micro- et macro-angiopathie, le traitement de l'hyperglycémie, l'hypercholestérolémie, l'hypertension, l'hyperinsulinémie, l'hyperlipidémie, l'athérosclérose ou l'ischémie myocardique.
CA002289001A 1997-05-06 1998-05-06 Nouveaux composes heterocycliques Abandoned CA2289001A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK0526/97 1997-05-06
DK52697 1997-05-06
PCT/DK1998/000177 WO1998050359A1 (fr) 1997-05-06 1998-05-06 Nouveaux composes heterocycliques

Publications (1)

Publication Number Publication Date
CA2289001A1 true CA2289001A1 (fr) 1998-11-12

Family

ID=8094549

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002289001A Abandoned CA2289001A1 (fr) 1997-05-06 1998-05-06 Nouveaux composes heterocycliques

Country Status (9)

Country Link
JP (1) JP2002515064A (fr)
KR (1) KR20010012299A (fr)
CN (1) CN1306511A (fr)
AU (1) AU741660B2 (fr)
BR (1) BR9809596A (fr)
CA (1) CA2289001A1 (fr)
NO (1) NO995430L (fr)
PL (1) PL336639A1 (fr)
ZA (1) ZA983800B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008062739A1 (fr) 2006-11-20 2008-05-29 Japan Tobacco Inc. Pyrazoles et leur utilisation en tant que médicaments
CN102093260B (zh) * 2009-12-14 2014-03-05 太景生物科技股份有限公司 哌啶衍生物的立体有择合成

Also Published As

Publication number Publication date
BR9809596A (pt) 2000-07-04
JP2002515064A (ja) 2002-05-21
NO995430D0 (no) 1999-11-05
ZA983800B (en) 1998-11-06
NO995430L (no) 1999-11-05
CN1306511A (zh) 2001-08-01
AU7205898A (en) 1998-11-27
AU741660B2 (en) 2001-12-06
KR20010012299A (ko) 2001-02-15
PL336639A1 (en) 2000-07-03

Similar Documents

Publication Publication Date Title
US6046214A (en) Heterocyclic compounds
AU724003B2 (en) 2-alkylpyrrolidines
EP1385508B1 (fr) Inhibiteurs de peptidase dipeptidyl destines au traitement ou a la prevention du diabete
JP2008056688A (ja) ピペリジン及びピロリジン
US5863903A (en) Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes
EP2393809B1 (fr) Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
AU2002306823A1 (en) Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
TW200530202A (en) Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
JPH08501110A (ja) コレステロール低下剤として有用なスピロシクロアルキル置換アゼチジノン
FR2785902A1 (fr) 4-aroylpiperidines antagonistes du recepteur du ccr-3, compositions pharmaceutiques les contenant, procede pour les utiliser et les preparer
CA2731789A1 (fr) Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique
EP0973738A1 (fr) Nouveaux composes heterocycliques
US5952363A (en) Pyrrolidine compounds useful in the treatment of diabetes
AU741660B2 (en) Novel heterocyclic compounds
WO1996030354A1 (fr) Derives d'acide epoxysuccinique
JP2526084B2 (ja) 新規なチアゾリジン誘導体
MXPA99009554A (en) Novel heterocyclic compounds
US20030187051A1 (en) Processes and intermediates for preparing glycogen phosphorylase inhibitors
CZ372799A3 (cs) Piperidinové sloučeniny a farmaceutický prostředek je obsahující
US5827856A (en) Method of treating insulin resistance
US6239148B1 (en) N-substituted azaheterocyclic carboxylic acids and esters thereof
EP2185525B1 (fr) Dérivés de pyrazole 3,5-carboxylates, leur préparation et leur application en thérapeutique
WO2009141533A2 (fr) Derives de pyrrole, leur preparation et leur application en therapeutique

Legal Events

Date Code Title Description
FZDE Dead