CA2286644A1 - Drug delivery via therapeutic hydrogels - Google Patents

Drug delivery via therapeutic hydrogels Download PDF

Info

Publication number
CA2286644A1
CA2286644A1 CA002286644A CA2286644A CA2286644A1 CA 2286644 A1 CA2286644 A1 CA 2286644A1 CA 002286644 A CA002286644 A CA 002286644A CA 2286644 A CA2286644 A CA 2286644A CA 2286644 A1 CA2286644 A1 CA 2286644A1
Authority
CA
Canada
Prior art keywords
drug delivery
delivery via
via therapeutic
hydrogels
medical devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002286644A
Other languages
French (fr)
Other versions
CA2286644C (en
Inventor
Frank Dicosmo
Valerio Ditizio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covalon Technologies Ltd
Original Assignee
Uroteq Inc.
Frank Dicosmo
Valerio Ditizio
The Governing Council Of The University Of Toronto
Biodel Systems, Inc.
Covalon Technologies Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uroteq Inc., Frank Dicosmo, Valerio Ditizio, The Governing Council Of The University Of Toronto, Biodel Systems, Inc., Covalon Technologies Inc. filed Critical Uroteq Inc.
Priority to CA002634700A priority Critical patent/CA2634700A1/en
Publication of CA2286644A1 publication Critical patent/CA2286644A1/en
Application granted granted Critical
Publication of CA2286644C publication Critical patent/CA2286644C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
    • A61L2300/436—Inhibitors, antagonists of receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/626—Liposomes, micelles, vesicles

Abstract

The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in--dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
CA002286644A 1997-04-15 1998-04-15 Drug delivery via therapeutic hydrogels Expired - Fee Related CA2286644C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002634700A CA2634700A1 (en) 1997-04-15 1998-04-15 Drug delivery via therapeutic hydrogels

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/843,342 US6132765A (en) 1996-04-12 1997-04-15 Drug delivery via therapeutic hydrogels
US08/843,342 1997-04-15
PCT/CA1998/000351 WO1998046287A2 (en) 1997-04-15 1998-04-15 Drug delivery via therapeutic hydrogels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002634700A Division CA2634700A1 (en) 1997-04-15 1998-04-15 Drug delivery via therapeutic hydrogels

Publications (2)

Publication Number Publication Date
CA2286644A1 true CA2286644A1 (en) 1998-10-22
CA2286644C CA2286644C (en) 2008-10-07

Family

ID=25289698

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002634700A Abandoned CA2634700A1 (en) 1997-04-15 1998-04-15 Drug delivery via therapeutic hydrogels
CA002286644A Expired - Fee Related CA2286644C (en) 1997-04-15 1998-04-15 Drug delivery via therapeutic hydrogels

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002634700A Abandoned CA2634700A1 (en) 1997-04-15 1998-04-15 Drug delivery via therapeutic hydrogels

Country Status (8)

Country Link
US (4) US6132765A (en)
EP (1) EP0984798B1 (en)
JP (1) JP2001523124A (en)
AT (1) ATE305803T1 (en)
AU (1) AU736584B2 (en)
CA (2) CA2634700A1 (en)
DE (1) DE69831802T2 (en)
WO (1) WO1998046287A2 (en)

Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
AU3212199A (en) 1998-03-31 1999-10-18 Scimed Life Systems, Inc. Temperature controlled solute delivery system
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
DE60029561T2 (en) * 1999-01-25 2007-07-19 Micronas Holding Gmbh IMMOBILIZATION OF MOLECULES ON SURFACES OVER POLYMER BRUSHES
US7892532B2 (en) * 1999-04-30 2011-02-22 Warsaw Orthopedic, In Emory University Intracellular delivery of osteoinductive proteins and peptides
US6576618B1 (en) * 1999-06-22 2003-06-10 Research Development Foundation Methods to enhance wound healing and enhanced wound coverage material
EP1124587A1 (en) * 1999-08-27 2001-08-22 Department of National Defence Hydrogel wound dressing containing liposome-encapsulated therapeutic agent
US6738661B1 (en) 1999-10-22 2004-05-18 Biosynergetics, Inc. Apparatus and methods for the controllable modification of compound concentration in a tube
WO2001066167A2 (en) * 2000-03-03 2001-09-13 Chuter Timothy A M Large vessel stents and occluders
US6613082B2 (en) * 2000-03-13 2003-09-02 Jun Yang Stent having cover with drug delivery capability
US6800298B1 (en) * 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
DE10025803A1 (en) * 2000-05-24 2001-12-20 Jms Co Ltd Polymer surface with biologically active properties and process for their production
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
EP1352072A4 (en) * 2001-01-17 2004-09-01 Zycos Inc Nucleic acid delivery formulations
US20060089721A1 (en) * 2001-01-17 2006-04-27 Muhanna Nabil L Intervertebral disc prosthesis and methods of implantation
WO2002062406A1 (en) * 2001-02-07 2002-08-15 Efmt Entwicklungs- Und Forschungszentrum Für Mikrotherapie Gmbh Dynamic implant coatings
CA2435306C (en) * 2001-02-16 2010-12-21 Stephan Wnendt Implants with fk506
WO2002070022A2 (en) * 2001-02-28 2002-09-12 Uroteq Inc. Method of making anti-microbial polymeric surfaces
US20110212152A1 (en) * 2001-02-28 2011-09-01 Ditizio Valerio Modified anti-microbial surfaces, devices and methods
AU2002245629A1 (en) * 2001-03-08 2002-09-24 Targesome, Inc. Stabilized therapeutic and imaging agents
DE10113108B4 (en) * 2001-03-15 2007-07-26 Dot Gmbh Active substance-containing calcium phosphate materials
US7615593B2 (en) * 2001-04-23 2009-11-10 Wisconsin Alumni Research Foundation Bifunctional-modified hydrogels
US20050276858A1 (en) * 2001-04-23 2005-12-15 Kao Weiyuan J Bifunctional-modified hydrogels
DE50103887D1 (en) * 2001-07-20 2004-11-04 Peter Hildebrandt Urological implant
DE10137102A1 (en) * 2001-07-30 2003-02-27 Deutsches Krebsforsch Polyvalent vaccine against diseases caused by papillomaviruses, processes for their production and their use
US20030064965A1 (en) * 2001-10-02 2003-04-03 Jacob Richter Method of delivering drugs to a tissue using drug-coated medical devices
WO2003030879A1 (en) * 2001-10-05 2003-04-17 Surmodics, Inc. Particle immobilized coatings and uses thereof
US20030100830A1 (en) * 2001-11-27 2003-05-29 Sheng-Ping Zhong Implantable or insertable medical devices visible under magnetic resonance imaging
US7488313B2 (en) * 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
US20040147466A1 (en) * 2002-01-17 2004-07-29 Barman Shikha P. Nucleic acid delivery formulations
CA2469665A1 (en) * 2002-01-22 2003-07-31 Pharmacia & Upjohn Company Infection-resistant medical devices
TW200304385A (en) * 2002-03-13 2003-10-01 Novartis Ag Materials containing multiple layers of vesicles
US20050240145A1 (en) * 2002-04-30 2005-10-27 Neal Scott Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
EP1509256B1 (en) * 2002-05-24 2009-07-22 Angiotech International Ag Compositions and methods for coating medical implants
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
US20050129769A1 (en) * 2002-06-03 2005-06-16 Barry Stephen E. Polymeric articles for carrying therapeutic agents
US20040034336A1 (en) * 2002-08-08 2004-02-19 Neal Scott Charged liposomes/micelles with encapsulted medical compounds
CA2503193A1 (en) * 2002-10-22 2004-05-06 The Biomerix Corporation Method and system for intravesicular delivery of therapeutic agents
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
KR101301653B1 (en) * 2002-10-29 2013-08-30 트랜세이브, 인코포레이티드 Sustained release of antiinfectives
WO2004043507A1 (en) * 2002-11-07 2004-05-27 Carbon Medical Technologies, Inc. Biocompatible medical device coatings
WO2005023331A2 (en) * 2003-09-04 2005-03-17 The United States Of America As Represented By The Department Of Veterans Affairs Hydrogel nanocompsites for ophthalmic applications
US6992127B2 (en) 2002-11-25 2006-01-31 Ast Products, Inc. Polymeric coatings containing a pH buffer agent
US7597903B2 (en) * 2002-12-02 2009-10-06 Shenkar College Of Engineering And Design Method and composition for producing catheters with antibacterial property
WO2004084973A2 (en) 2003-03-24 2004-10-07 Becton, Dickinson And Company Invisible antimicrobial glove and hand antiseptic
WO2004096152A2 (en) * 2003-04-24 2004-11-11 Arizona Board Of Regents In situ gelling self-reactive materials for embolization
US20040254545A1 (en) * 2003-06-16 2004-12-16 Rider Dean Loller Method and apparatus for extending feeding tube longevity
JP4320572B2 (en) * 2003-07-11 2009-08-26 ソニー株式会社 Signal processing apparatus and method, recording medium, and program
US20050074453A1 (en) * 2003-10-02 2005-04-07 Ferree Bret A. Methods of preventing adhesions following laminectomies and other surgical procedures
EP1691854B1 (en) * 2003-11-03 2011-09-14 Medtronic, Inc. Hydrogel providing cell-specific ingrowth
AU2004293463A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US20050112151A1 (en) * 2003-11-20 2005-05-26 Horng Liou L. Skin adherent hydrogels
EP1694333A2 (en) * 2003-11-25 2006-08-30 Deltanoid Pharmaceuticals, Inc. Methods for reducing body fat using vitamin d compounds
JP2008504912A (en) * 2004-06-30 2008-02-21 コヴァロン テクノロジーズ リミテッド Non-adhesive hydrogel
US7221982B2 (en) * 2004-07-12 2007-05-22 Cardiac Pacemakers, Inc. Apparatus and method of coating implantable leads
US8312836B2 (en) 2004-09-28 2012-11-20 Atrium Medical Corporation Method and apparatus for application of a fresh coating on a medical device
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US8962023B2 (en) 2004-09-28 2015-02-24 Atrium Medical Corporation UV cured gel and method of making
US8367099B2 (en) 2004-09-28 2013-02-05 Atrium Medical Corporation Perforated fatty acid films
WO2006036967A1 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Solubilizing a drug for use in a coating
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US20110097402A1 (en) * 2004-09-30 2011-04-28 Covalon Technologies Inc. Non-adhesive elastic gelatin matrices
WO2012050591A1 (en) 2010-10-15 2012-04-19 Rutgers, The State University Of New Jersey Hydrogel formulation for dermal and ocular delivery
WO2006069344A2 (en) * 2004-12-22 2006-06-29 Rutgers, The State University Of New Jersey Controlled release hydrogels
WO2006079015A2 (en) * 2005-01-21 2006-07-27 Vertex Pharmaceuticals Incorporated Quorum sensing modulators
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US8029482B2 (en) 2005-03-04 2011-10-04 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US8202259B2 (en) 2005-03-04 2012-06-19 C. R. Bard, Inc. Systems and methods for identifying an access port
EP1858565B1 (en) 2005-03-04 2021-08-11 C.R. Bard, Inc. Access port identification systems and methods
AU2006225991B2 (en) * 2005-03-21 2010-01-21 Lifecare Innovations Pvt. Ltd. A novel inter and intra multilamellar vesicular composition.
US10307581B2 (en) 2005-04-27 2019-06-04 C. R. Bard, Inc. Reinforced septum for an implantable medical device
EP2324878B1 (en) 2005-04-27 2014-08-20 C.R. Bard, Inc. Infusion apparatuses provided with septum
EP1874393B1 (en) 2005-04-27 2017-09-06 C.R.Bard, Inc. Infusion apparatuses
EP1893130A4 (en) 2005-06-17 2015-08-26 Georgia Tech Res Inst Coated microstructures and method of manufacture thereof
US7919583B2 (en) * 2005-08-08 2011-04-05 Discovery Genomics, Inc. Integration-site directed vector systems
PL1919450T3 (en) * 2005-09-01 2014-11-28 Meda Ab Antihistamine- and corticosteroid-containing liposome composition and its use for the manufacture of a medicament for treating rhinitis and related disorders
US8574627B2 (en) 2006-11-06 2013-11-05 Atrium Medical Corporation Coated surgical mesh
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
EP1933991A4 (en) 2005-10-15 2012-05-02 Atrium Medical Corp Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
EP3067047B1 (en) 2005-12-08 2022-04-20 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections
CA2636716C (en) * 2006-01-13 2014-12-23 Surmodics, Inc. Microparticle containing matrices for drug delivery
US20070184085A1 (en) * 2006-02-03 2007-08-09 Boston Scientific Scimed, Inc. Ultrasound activated medical device
ITMI20060556A1 (en) * 2006-03-24 2007-09-25 Univ Pavia INTERACTIVE MEDICATIONS FOR THE CARE OF DERMATOLOGICAL DISEASES
DE102006015271A1 (en) * 2006-04-01 2007-10-11 Lohmann & Rauscher Gmbh & Co. Kg Biguanide-containing liposomes
US7638344B2 (en) * 2006-06-28 2009-12-29 Surmodics, Inc. Active agent eluting matrices with particulates
US8747738B2 (en) 2006-08-15 2014-06-10 Abbott Cardiovascular Systems Inc. Sterilization methods for medical devices
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
KR101428122B1 (en) 2006-12-15 2014-08-07 라이프본드 엘티디. Gelatin-transglutaminase hemostatic dressings and sealants
US20080181928A1 (en) * 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
EP1980277A1 (en) * 2007-03-17 2008-10-15 Peter Hildebrandt Gastroenterological medical product, in particular stent for the bile duct or pancreatic duct
US8093039B2 (en) * 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
DE102007039871A1 (en) * 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Soft tissue implant with antibacterial effect
DE602008005771D1 (en) * 2007-08-27 2011-05-05 Theravance Inc DISUBSTITUTED ALKYL-8-AZABICYCLOÄ3.2.1ÜOKTAN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
US20090099651A1 (en) * 2007-10-10 2009-04-16 Miv Therapeutics, Inc. Lipid coatings for implantable medical devices
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
WO2009128944A2 (en) * 2008-04-18 2009-10-22 Surmodics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
WO2009131672A1 (en) * 2008-04-22 2009-10-29 University Of Massachusetts Stabilized liposome compositions and related methods of use
EP2303026B1 (en) 2008-06-17 2020-09-09 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
EP2303341A2 (en) * 2008-06-18 2011-04-06 Lifebond Ltd A method for enzymatic cross-linking of a protein
JP5450612B2 (en) 2008-06-18 2014-03-26 ライフボンド リミテッド Improved cross-linking composition
CA2728186A1 (en) * 2008-06-18 2009-12-23 Lifebond Ltd Methods and devices for use with sealants
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
WO2010008564A2 (en) * 2008-07-16 2010-01-21 Recombinetics Plaice dna transposon system
US20100070013A1 (en) * 2008-09-18 2010-03-18 Medtronic Vascular, Inc. Medical Device With Microsphere Drug Delivery System
US11890443B2 (en) 2008-11-13 2024-02-06 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
WO2010060104A2 (en) * 2008-11-24 2010-05-27 Moma Therapeutics Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone praticles as scaffolds for tissue regeneration
EP2373270B8 (en) 2009-01-07 2023-04-12 entrotech life sciences, inc. Chlorhexidine-containing antimicrobial laminates
US8709473B1 (en) * 2009-01-28 2014-04-29 Abbott Cardiovascular Systems Inc. Method of targeting hydrophobic drugs to vascular lesions
US20100239651A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Nitrilopropionamide delivery systems
US20100239626A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Propanediol delivery systems
US20100239627A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Quarternary ammonium salts delivery systems
US20100239630A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Phosphonium salts delivery systems
US20100239650A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Isothiazolin biodelivery systems
US20100249783A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Drug-eluting implant cover
US20100247600A1 (en) * 2009-03-24 2010-09-30 Warsaw Orthopedic, Inc. Therapeutic drug eluting implant cover and method of making the same
US9078712B2 (en) * 2009-04-15 2015-07-14 Warsaw Orthopedic, Inc. Preformed drug-eluting device to be affixed to an anterior spinal plate
US9414864B2 (en) 2009-04-15 2016-08-16 Warsaw Orthopedic, Inc. Anterior spinal plate with preformed drug-eluting device affixed thereto
JP5741576B2 (en) * 2009-06-02 2015-07-01 コンセプト メディカル インコーポレイテッド Drug delivery medical device
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
FR2949688B1 (en) 2009-09-04 2012-08-24 Sofradim Production FABRIC WITH PICOTS COATED WITH A BIORESORBABLE MICROPOROUS LAYER
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
ES2695907T3 (en) 2009-11-17 2019-01-11 Bard Inc C R Overmolded access port that includes anchoring and identification features
BR112012015029A2 (en) 2009-12-22 2017-06-27 Lifebond Ltd cross-linked matrix, method for controlling the formation of a matrix, method or matrix, method for sealing a tissue against leakage of a body fluid, hemostatic agent or surgical seal, composition for sealing a wound, use of the composition, composition for a delivery vehicle drug composition, tissue engineering composition, and method for modifying a composition
DK2516570T3 (en) 2009-12-23 2017-05-01 Dsm Ip Assets Bv PROCEDURE FOR ACTIVATING SURFACES OF SILICONE RUBBER
WO2012009707A2 (en) 2010-07-16 2012-01-19 Atrium Medical Corporation Composition and methods for altering the rate of hydrolysis of cured oil-based materials
US20120028335A1 (en) 2010-07-28 2012-02-02 Life Technologies Corporation Anti-viral azide-containing compounds
US9144575B2 (en) 2010-07-28 2015-09-29 Life Technologies Corporation Anti-viral azide containing compounds
US8961544B2 (en) 2010-08-05 2015-02-24 Lifebond Ltd. Dry composition wound dressings and adhesives comprising gelatin and transglutaminase in a cross-linked matrix
US8753608B2 (en) * 2010-08-24 2014-06-17 Canon Kabushiki Kaisha Complex and contrast agent for photoimaging using the same
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
FR2972626B1 (en) 2011-03-16 2014-04-11 Sofradim Production PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED
US20140127287A1 (en) * 2011-05-11 2014-05-08 Wisconsin Alumni Research Foundation (Warf) Liposome-encapsulated hydrogels for use in a drug delivery system
FR2977790B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
FR2977789B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
KR20140063616A (en) * 2011-07-20 2014-05-27 브라이엄 영 유니버시티 Hydrophobic ceragenin compounds and devices incorporating same
US8945217B2 (en) 2011-08-25 2015-02-03 Brigham Young University Medical devices incorporating ceragenin-containing composites
JP6038154B2 (en) 2011-09-13 2016-12-07 ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ Composition for the treatment of bone disease and fractured bone
US9694019B2 (en) 2011-09-13 2017-07-04 Brigham Young University Compositions and methods for treating bone diseases and broken bones
US9603859B2 (en) 2011-09-13 2017-03-28 Brigham Young University Methods and products for increasing the rate of healing of tissue wounds
AU2012308530B2 (en) 2011-09-13 2016-04-21 Brigham Young University Products for healing of tissue wounds
WO2013046058A2 (en) 2011-09-30 2013-04-04 Sofradim Production Reversible stiffening of light weight mesh
JP6111013B2 (en) * 2011-10-30 2017-04-05 株式会社セルシード Tendon cell sheet and manufacturing method thereof
EP2793832B1 (en) 2011-12-21 2018-05-23 Brigham Young University Oral care compositions
FR2985271B1 (en) 2011-12-29 2014-01-24 Sofradim Production KNITTED PICOTS
FR2985170B1 (en) 2011-12-29 2014-01-24 Sofradim Production PROSTHESIS FOR INGUINAL HERNIA
SG11201404361UA (en) 2012-01-26 2014-09-26 Life Technologies Corp Methods for increasing the infectivity of viruses
US9533063B1 (en) 2012-03-01 2017-01-03 Brigham Young University Aerosols incorporating ceragenin compounds and methods of use thereof
EP3225113B1 (en) 2012-05-02 2020-09-02 Brigham Young University Methods for making ceragenin particulate materials
CN104349783B (en) 2012-05-21 2018-07-13 英斯麦德公司 The system for treating pulmonary infection
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
FR2994185B1 (en) 2012-08-02 2015-07-31 Sofradim Production PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER
FR2995779B1 (en) 2012-09-25 2015-09-25 Sofradim Production PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION
FR2995788B1 (en) 2012-09-25 2014-09-26 Sofradim Production HEMOSTATIC PATCH AND PREPARATION METHOD
FR2995778B1 (en) 2012-09-25 2015-06-26 Sofradim Production ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME
AU2013322268B2 (en) 2012-09-28 2017-08-31 Sofradim Production Packaging for a hernia repair device
AU2013331136B2 (en) 2012-10-17 2016-05-12 Brigham Young University Treatment and prevention of mastitis
RU2675859C2 (en) 2012-11-29 2018-12-25 Инсмед Инкорпорейтед Stabilised vancomycin formulations
CN105451742B (en) 2013-01-07 2021-04-06 布莱阿姆青年大学 Methods for reducing cell proliferation and treating certain diseases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
CA2907082C (en) 2013-03-15 2021-05-04 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
FR3006578B1 (en) 2013-06-07 2015-05-29 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
FR3006581B1 (en) 2013-06-07 2016-07-22 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
EP2994175A1 (en) 2014-02-04 2016-03-16 Abbott Cardiovascular Systems, Inc. Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9867836B2 (en) 2014-03-13 2018-01-16 Brigham Young University Lavage and/or infusion using CSA compounds for increasing fertility in a mammal
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
EP3131540B1 (en) 2014-04-18 2023-11-22 Entrotech, Inc. Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby
US9686966B2 (en) 2014-04-30 2017-06-27 Brigham Young University Methods and apparatus for cleaning or disinfecting a water delivery system
PT3142643T (en) 2014-05-15 2019-10-28 Insmed Inc Methods for treating pulmonary non-tuberculous mycobacterial infections
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
EP3000432B1 (en) 2014-09-29 2022-05-04 Sofradim Production Textile-based prosthesis for treatment of inguinal hernia
EP3000433B1 (en) 2014-09-29 2022-09-21 Sofradim Production Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis
IL234929B (en) * 2014-10-01 2021-01-31 Yeda Res & Dev Liposomes-containing antifouling compositions and uses thereof
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
EP3029189B1 (en) 2014-12-05 2021-08-11 Sofradim Production Prosthetic porous knit, method of making same and hernia prosthesis
US9757774B2 (en) * 2015-01-15 2017-09-12 MyExposome, Inc. Passive sampling devices
EP3059255B1 (en) 2015-02-17 2020-05-13 Sofradim Production Method for preparing a chitosan-based matrix comprising a fiber reinforcement member
WO2016172553A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
US10370403B2 (en) 2015-04-22 2019-08-06 Brigham Young University Methods for the synthesis of ceragenins
EP3085337B1 (en) 2015-04-24 2022-09-14 Sofradim Production Prosthesis for supporting a breast structure
US10126298B2 (en) 2015-05-04 2018-11-13 Arman Nabatian Hydrogels containing embedded substrates for targeted binding of molecules
KR102593738B1 (en) * 2015-05-14 2023-10-24 어쏘시에이션 포 더 어드벤스먼트 오브 티슈 엔지니어링 앤드 셀 베이스드 테크놀로지스 & 테라피즈 (에이4테크)-어쏘시아상 Ureteral stent, manufacturing method thereof, and use thereof
US9434759B1 (en) 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
US9872938B2 (en) * 2015-05-22 2018-01-23 Orthobond, Inc. Methods, compositions and techniques for polydimethylsiloxane surface modifications
ES2676072T3 (en) 2015-06-19 2018-07-16 Sofradim Production Synthetic prosthesis comprising a knitted fabric and a non-porous film and method of forming it
SG10201913355RA (en) 2015-09-17 2020-02-27 Histide Ag Pharmaceutical association for converting a neoplastic cell into a non-neoplastic cell and uses thereof
RU2617062C1 (en) * 2015-10-22 2017-04-19 Акционерное общество "Медсил" Plastic endoprosthesis for stenting pancreatic ducts
EP3195830B1 (en) 2016-01-25 2020-11-18 Sofradim Production Prosthesis for hernia repair
CN110201242A (en) * 2016-02-08 2019-09-06 祥丰医疗私人有限公司 A kind of medical device
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
RU2624535C1 (en) * 2016-10-14 2017-07-04 Акционерное общество "Медсил" Plastic endoprosthesis for stenting pancreatic ducts
EP3312325B1 (en) 2016-10-21 2021-09-22 Sofradim Production Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained
WO2018129470A1 (en) * 2017-01-09 2018-07-12 The Board Of Trustees Of The Leland Stanford Junior University Reversing deficient hedgehog signaling restores deficient skeletal regeneration
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
EP3398554A1 (en) 2017-05-02 2018-11-07 Sofradim Production Prosthesis for inguinal hernia repair
EP3687560A4 (en) * 2017-09-29 2021-06-23 Bard Shannon Limited Composition and method for controlled drug release from a tissue
EP3773505A4 (en) 2018-03-30 2021-12-22 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
EP3653171A1 (en) 2018-11-16 2020-05-20 Sofradim Production Implants suitable for soft tissue repair

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
US4749585A (en) * 1986-04-11 1988-06-07 University Of Medicine And Dentistry Of New Jersey Antibiotic bonded prosthesis and process for producing same
US5575815A (en) * 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
WO1991009616A1 (en) * 1989-12-22 1991-07-11 Yale University Quinolone antibiotics encapsulated in lipid vesicles
FR2668063A1 (en) * 1990-10-17 1992-04-24 Fabre Pierre Cosmetique LIPOSOMES OF THERMAL WATER STABILIZED IN A DNA GEL.
EP0489206B1 (en) * 1990-12-04 1997-02-19 Zenith Technology Corporation Limited Synthetic skin substitutes
CA2097163C (en) * 1992-06-01 2002-07-30 Marianna Foldvari Topical patch for liposomal drug delivery system
US5863556A (en) * 1993-08-20 1999-01-26 Euro-Celtique, S.A. Preparations for the external application of antiseptic agents and/or agents promoting the healing of wounds
US5433745A (en) * 1993-10-13 1995-07-18 Allergan, Inc. Corneal implants and methods for producing same
DE69530919T2 (en) * 1994-04-08 2004-05-13 Atrix Laboratories, Inc., Fort Collins ASSOCIATED POLYMER SYSTEM FOR USE WITH A MEDICAL DEVICE
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
CA2181390C (en) * 1995-07-18 2001-04-24 Pankaj Modi Phospholipid formulations

Also Published As

Publication number Publication date
JP2001523124A (en) 2001-11-20
EP0984798B1 (en) 2005-10-05
AU736584B2 (en) 2001-08-02
US20020051812A1 (en) 2002-05-02
CA2634700A1 (en) 1998-10-22
DE69831802T2 (en) 2006-07-06
DE69831802D1 (en) 2005-11-10
US20020009485A1 (en) 2002-01-24
EP0984798A2 (en) 2000-03-15
CA2286644C (en) 2008-10-07
US6475516B2 (en) 2002-11-05
ATE305803T1 (en) 2005-10-15
US6228393B1 (en) 2001-05-08
WO1998046287A3 (en) 1999-02-11
AU7019898A (en) 1998-11-11
WO1998046287A2 (en) 1998-10-22
US6132765A (en) 2000-10-17

Similar Documents

Publication Publication Date Title
CA2286644A1 (en) Drug delivery via therapeutic hydrogels
CA2257976A1 (en) Compositions and methods for coating medical devices
CA2457564A1 (en) Particle immobilized coatings and uses thereof
EP2255836A3 (en) Medical devices containing rapamycin analogs
AU8070298A (en) Surface coatings for catheters, direct contacting diagnostic and therapeutic devices
CA2447302A1 (en) Two-phase, water-absorbent bioadhesive composition
CA2268187A1 (en) Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
CA2329128A1 (en) Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
EP2258415A3 (en) Medical devices containing rapamycin analogs
WO1997005185A3 (en) Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
CA2304976A1 (en) Delivery of poly(ethylene glycol)-conjugated molecules from degradable hydrogels
CA2165740A1 (en) Anti-adhesion films and compositions for medical use
CA2274222A1 (en) Biomedical devices with hydrophilic coatings
AU6559800A (en) Use of hyaluronic acid derivatives in pharmaceutical preparations and biomaterials for the prevention and treatment of cutaneous scars
EP0955044A3 (en) Method of inhibiting bacterial or fungal growth using a complexing agent
AU6368700A (en) Universal biocompatible coating platform for medical devices
AU1663695A (en) Central venous catheters loaded with antibiotics of the ramoplanin group preventing development of catheter related infections
WO1998022541A3 (en) Method for coating substrates
AU7313696A (en) Biocompatible lubricious hydrophilic materials for medical devices
CA2136331A1 (en) New pharmaceutical uses of krill enzymes
CA2165995A1 (en) Medicaments for the treatment of restenosis and arterial sclerosis
AU2002345995A1 (en) Contrast delivery syringe with internal hydrophilic surface treatment for the prevention of bubble adhesion
AU1067599A (en) Peptide compositions for the treatment and prevention of hiv infection
CA2324365A1 (en) Moulded bodies made of thermoplastic polyurethane containing an active substance
WO2000000214A3 (en) Pharmaceutical preparations for use in combatting or preventing surface infections caused by microorganisms

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140415