CA2281938A1 - Procede de production d'immunoglobuline serique a administration intraveineuse et produit resultant - Google Patents

Procede de production d'immunoglobuline serique a administration intraveineuse et produit resultant Download PDF

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Publication number
CA2281938A1
CA2281938A1 CA002281938A CA2281938A CA2281938A1 CA 2281938 A1 CA2281938 A1 CA 2281938A1 CA 002281938 A CA002281938 A CA 002281938A CA 2281938 A CA2281938 A CA 2281938A CA 2281938 A1 CA2281938 A1 CA 2281938A1
Authority
CA
Canada
Prior art keywords
gamma globulin
solution
globulin solution
fraction
detergent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002281938A
Other languages
English (en)
Inventor
Raja R. Mamidi
Andranik Bagdasarian
Kazuo Takechi
Gorgonio Canaveral
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alpha Therapeutic Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2281938A1 publication Critical patent/CA2281938A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

L'invention concerne un procédé de production d'une solution de gammaglobuline à administration intraveineuse sensiblement exempte de contamination virale. Ce procédé consiste à soumettre à un traitement d'inactivation virale et à fractionner une solution de gammaglobuline impure puis à traiter la gammaglobuline purifiée avec un mélange solvant-détergent pour une inactivation virale complémentaire.
CA002281938A 1997-12-24 1998-12-07 Procede de production d'immunoglobuline serique a administration intraveineuse et produit resultant Abandoned CA2281938A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99795297A 1997-12-24 1997-12-24
US08/997,952 1997-12-24
PCT/US1998/025208 WO1999033484A1 (fr) 1997-12-24 1998-12-07 Procede de production d'immunoglobuline serique a administration intraveineuse et produit resultant

Publications (1)

Publication Number Publication Date
CA2281938A1 true CA2281938A1 (fr) 1999-07-08

Family

ID=25544595

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002281938A Abandoned CA2281938A1 (fr) 1997-12-24 1998-12-07 Procede de production d'immunoglobuline serique a administration intraveineuse et produit resultant

Country Status (15)

Country Link
EP (1) EP0971727A4 (fr)
JP (1) JP2001514672A (fr)
KR (1) KR20000075562A (fr)
CN (1) CN1214042C (fr)
AR (1) AR018260A1 (fr)
AU (1) AU747893B2 (fr)
BR (1) BR9807598A (fr)
CA (1) CA2281938A1 (fr)
CO (1) CO4970799A1 (fr)
IL (1) IL131471A0 (fr)
MY (1) MY117328A (fr)
RU (1) RU2198668C2 (fr)
TW (1) TW546144B (fr)
UA (1) UA64742C2 (fr)
WO (1) WO1999033484A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4685238B2 (ja) 1998-06-09 2011-05-18 ツエー・エス・エル・ベーリング・アクチエンゲゼルシヤフト 静脈投与用免疫グロブリン及び他の免疫グロブリン生成物の製造法
WO2000076534A1 (fr) * 1999-06-15 2000-12-21 Alpha Therapeutic Corporation Procede de fabrication d'immunoglobuline intraveineuse et produit resultant
JP2004525077A (ja) * 2000-09-28 2004-08-19 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド イムノグロブリンｇ強化血漿画分の経口投与による免疫媒介性疾病の治療
ES2184594B1 (es) * 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
US6893639B2 (en) 2001-10-19 2005-05-17 Hemacare Corporation Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates
ES2626268T3 (es) 2002-09-11 2017-07-24 Chugai Seiyaku Kabushiki Kaisha Método de purificación de proteínas
TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
KR100791502B1 (ko) * 2006-09-29 2008-01-03 한스바이오메드 주식회사 바이러스 불활화된 무세포 인체 이식재 생산방법
EP2350271B1 (fr) * 2008-11-20 2016-01-27 Biogen MA Inc. Inactivation de virus enveloppés par l'arginine
IL212911A0 (en) * 2011-05-16 2011-07-31 Omrix Biopharmaceuticals Ltd Immunoglobulin reduced in thrombogenic contaminants and preparation thereof
ES2381828B1 (es) * 2012-03-20 2012-11-16 Grifols, S.A. PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
CA2941230C (fr) * 2014-03-11 2020-08-25 Green Cross Holdings Corporation Procede de purification d'immunoglobuline
CN107880116B (zh) * 2016-09-30 2023-02-03 盖立复集团公司 用于制备免疫球蛋白的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2604759C2 (de) * 1976-02-07 1983-06-01 SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld Verfahren zur Gewinnung von iv-verträglichen Γglobulinen
US4820805A (en) * 1983-07-14 1989-04-11 New York Blood Center, Inc. Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4835257A (en) * 1984-07-07 1989-05-30 Armour Pharma Gmbh Process for preparing gamma globulin suitable for intravenous administration using peg and a citrate buffer
FR2582515B1 (fr) * 1985-05-30 1988-11-04 Merieux Inst Procede de preparation de gamma-gobulines administrables par voie intraveineuse et gamma-globulines obtenues
JPH0662436B2 (ja) * 1986-05-19 1994-08-17 株式会社ミドリ十字 静注用免疫グロブリン製剤の製造方法
US4841023A (en) * 1986-06-25 1989-06-20 New York Blood Center, Inc. Inactivation of viruses in labile protein-containing compositions using fatty acids
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt
JP2965069B2 (ja) * 1989-01-13 1999-10-18 吉富製薬株式会社 蛋白質含有組成物の製造方法
ES2057191T5 (es) * 1989-01-13 2003-05-01 Mitsubishi Pharma Corp Metodo de produccion para una composicion que contiene proteinas.
ES2087156T3 (es) * 1989-06-15 1996-07-16 Rorer Int Overseas Metodos para la inactivacion de virus en composiciones farmaceuticas contaminadas por virus.
US5177194A (en) * 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
JP3145696B2 (ja) * 1990-10-05 2001-03-12 日本ケミカルリサーチ株式会社 分泌型免疫グロブリンａ製剤の製造法
US5110910A (en) * 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
DE4431833C1 (de) * 1994-09-07 1995-05-18 Blutspendedienst Der Drk Lande Verfahren zur Herstellung eines AHF-Konzentrates
JP4003235B2 (ja) * 1994-09-30 2007-11-07 三菱ウェルファーマ株式会社 静注用免疫グロブリン製剤の製造方法

Also Published As

Publication number Publication date
EP0971727A1 (fr) 2000-01-19
CN1252729A (zh) 2000-05-10
RU2198668C2 (ru) 2003-02-20
KR20000075562A (ko) 2000-12-15
CO4970799A1 (es) 2000-11-07
CN1214042C (zh) 2005-08-10
IL131471A0 (en) 2001-01-28
BR9807598A (pt) 2000-02-22
AU747893B2 (en) 2002-05-30
UA64742C2 (uk) 2004-03-15
AU1703899A (en) 1999-07-19
WO1999033484A1 (fr) 1999-07-08
MY117328A (en) 2004-06-30
JP2001514672A (ja) 2001-09-11
EP0971727A4 (fr) 2005-01-19
TW546144B (en) 2003-08-11
AR018260A1 (es) 2001-11-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20081208