CA2279492A1 - Tolerance immunologique aux epitopes du hiv - Google Patents
Tolerance immunologique aux epitopes du hiv Download PDFInfo
- Publication number
- CA2279492A1 CA2279492A1 CA002279492A CA2279492A CA2279492A1 CA 2279492 A1 CA2279492 A1 CA 2279492A1 CA 002279492 A CA002279492 A CA 002279492A CA 2279492 A CA2279492 A CA 2279492A CA 2279492 A1 CA2279492 A1 CA 2279492A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- cells
- epitopes
- cell
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
- G01N2333/162—HIV-1, HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, DC4-Binding site
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne des protéines d'immunoglobuline de fusion (fIg) comprenant un ou plusieurs épitopes hétérologues associés à des maladies pour lesquelles la réponse immunitaire est négative, lesdites protéines étant utiles pour induire une tolérance auxdits épitopes. Les épitopes gp120 du HIV-1 associés à l'intérieur d'un cadre à une chaîne lourde (H) d'Ig sont des produits de synthèse utiles pour induire une tolérance au HIV, spécifique aux épitopes. Le traitement d'un sujet avec ce type de produit de synthèse, ou bien avec des cellules lymphoïdes ou hématopoïétiques exprimant ou sécrétant ces molécules fIg, induit une tolérance immunologique spécifique aux épitopes considérés. En empêchant la production d'anticorps dirigés contre les épitopes gp120 déterminés, cette tolérance peut prévenir ou inhiber l'apoptose de "voisinage" sur les cellules T hôtes non infectées ayant effectué une liaison, à leurs molécules CD4 de surface, avec la protéine gp 120 du HIV et subissant ensuite une réticulation sous l'effet d'anticorps parasites anti-gp120. Cela donne pour les cellules T en question une amorce à l'apoptose, en présence des antigènes qui les activent. On utilise de préférence les épitopes gp120 correspondant à des épitopes de lymphocites B non neutralisants ou certains épitopes de lymphocytes T auxiliaires pour élaborer les molécules fIg. Outre les chaînes H de fIg et les molécules d'Ig complètes, l'invention concerne l'ADN codant les chaînes H en question et les cellules transformées par ce type d'ADN.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4058197P | 1997-02-13 | 1997-02-13 | |
US60/040,581 | 1997-02-13 | ||
PCT/US1998/002766 WO1998036087A1 (fr) | 1997-02-13 | 1998-02-13 | Tolerance immunologique aux epitopes du hiv |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2279492A1 true CA2279492A1 (fr) | 1998-08-20 |
Family
ID=21911760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002279492A Abandoned CA2279492A1 (fr) | 1997-02-13 | 1998-02-13 | Tolerance immunologique aux epitopes du hiv |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0973933A1 (fr) |
CA (1) | CA2279492A1 (fr) |
WO (1) | WO1998036087A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7115262B1 (en) | 1999-03-16 | 2006-10-03 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric protein for prevention and treatment of HIV infection |
GB9926084D0 (en) * | 1999-11-03 | 2000-01-12 | King S College London | Recombinant fusion molecules |
EP2258712A3 (fr) | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Compositions et procédés permettant d'initier ou d'ameliorer les réponses des cellules T limitées par le complexe majeur d 'histocompatibilité de classe I ou II et un anticorps au moyen de motifs d'ARN non codants immunomodulateurs |
CA2562385A1 (fr) * | 2004-04-09 | 2005-10-20 | University Of Manitoba | Identification de la sequence precise d'acides amines de l'epitope identifie par l'anticorps monoclonal igg1b12 puissant de neutralisation anti-vih 1 humain |
WO2007022477A2 (fr) * | 2005-08-17 | 2007-02-22 | Multicell Immunotherapeutics, Inc. | Méthodes et compositions pour produire et contrôler le profil effecteur de lymphocytes t par chargement et activation simultanés de sous-ensembles sélectionnés de cellules présentatrices d'antigène |
EP1878744A1 (fr) | 2006-07-13 | 2008-01-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Epitope-tag pour des récepteurs de cellules T exprimés en surface, leurs utilisations et méthode de selection de cellules hôtes les exprimant |
US10246505B2 (en) | 2013-11-25 | 2019-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors to control HIV infection |
CA2981509A1 (fr) | 2015-03-30 | 2016-10-06 | The Board Of Regents Of The Nevada System Of Higher Educ. On Behalf Of The University Of Nevada, La | Compositions comprenant des talen et methodes de traitement du vih |
WO2016196249A1 (fr) | 2015-05-29 | 2016-12-08 | University Of Utah Research Foundation | Peptides recombinants de type élastine à tolérance immunitaire et sans tolérance immunitaire et procédés d'utilisation |
WO2016207782A1 (fr) * | 2015-06-22 | 2016-12-29 | STRELNIKOV, Evgeny | Oligopeptides synthétiques immunogènes pour un vaccin contre le vih |
KR20230007557A (ko) | 2017-09-22 | 2023-01-12 | 카이트 파마 인코포레이티드 | 키메라 폴리펩티드 및 그의 용도 |
US11198722B2 (en) | 2017-10-06 | 2021-12-14 | University Of Utah Research Foundation | Immune tolerant elastin-like peptide tetramer guided nanoparticles and methods of use |
CN113621033A (zh) * | 2019-11-08 | 2021-11-09 | 贵州医科大学 | 一种具有seq id no.3序列的多肽以及具有强adcc效应的抗体和应用 |
-
1998
- 1998-02-13 CA CA002279492A patent/CA2279492A1/fr not_active Abandoned
- 1998-02-13 EP EP98908538A patent/EP0973933A1/fr not_active Withdrawn
- 1998-02-13 WO PCT/US1998/002766 patent/WO1998036087A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0973933A1 (fr) | 2000-01-26 |
WO1998036087A1 (fr) | 1998-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |