CA2277121A1 - Inhibiteurs macrocycliques de metalloproteinases matricielles et de secretion de fnt.alpha. - Google Patents

Inhibiteurs macrocycliques de metalloproteinases matricielles et de secretion de fnt.alpha. Download PDF

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Publication number
CA2277121A1
CA2277121A1 CA002277121A CA2277121A CA2277121A1 CA 2277121 A1 CA2277121 A1 CA 2277121A1 CA 002277121 A CA002277121 A CA 002277121A CA 2277121 A CA2277121 A CA 2277121A CA 2277121 A1 CA2277121 A1 CA 2277121A1
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CA
Canada
Prior art keywords
carbon atoms
alkyl
group
substituted
haloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002277121A
Other languages
English (en)
Inventor
Steven K. Davidsen
Douglas H. Steinman
George S. Sheppard
Lianhong Xu
James H. Holms
Yan Guo
Alan Scott Florjancic
James B. Summers
Michael R. Michaelides
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1998/000144 external-priority patent/WO1998030551A1/fr
Publication of CA2277121A1 publication Critical patent/CA2277121A1/fr
Abandoned legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cette invention concerne des composés macrocycliques qui correspondent à la formule (I). Ces composés consistent en de puissants inhibiteurs de métalloprotéinase matricielle, et peuvent être utilisés dans le traitement de maladies où la métalloprotéinase matricielle joue un rôle. Cette invention concerne également des compositions inhibant la métalloprotéinase matricielle, ainsi qu'un procédé d'inhibition de métalloprotéinase matricielle chez un mammifère.
CA002277121A 1997-01-07 1998-01-07 Inhibiteurs macrocycliques de metalloproteinases matricielles et de secretion de fnt.alpha. Abandoned CA2277121A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78201697A 1997-01-07 1997-01-07
US08/782,016 1997-01-07
PCT/US1998/000144 WO1998030551A1 (fr) 1997-01-07 1998-01-07 INHIBITEURS MACROCYCLIQUES DE METALLOPROTEINASES MATRICIELLES ET DE SECRETION DE FNT$g(a)

Publications (1)

Publication Number Publication Date
CA2277121A1 true CA2277121A1 (fr) 1998-07-16

Family

ID=31188936

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002277121A Abandoned CA2277121A1 (fr) 1997-01-07 1998-01-07 Inhibiteurs macrocycliques de metalloproteinases matricielles et de secretion de fnt.alpha.

Country Status (2)

Country Link
AR (1) AR011060A1 (fr)
CA (1) CA2277121A1 (fr)

Also Published As

Publication number Publication date
AR011060A1 (es) 2000-08-02

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Legal Events

Date Code Title Description
FZDE Discontinued