CA2274063C - Substituted pyrimidine compounds and their use - Google Patents
Substituted pyrimidine compounds and their use Download PDFInfo
- Publication number
- CA2274063C CA2274063C CA002274063A CA2274063A CA2274063C CA 2274063 C CA2274063 C CA 2274063C CA 002274063 A CA002274063 A CA 002274063A CA 2274063 A CA2274063 A CA 2274063A CA 2274063 C CA2274063 C CA 2274063C
- Authority
- CA
- Canada
- Prior art keywords
- amino
- radicals
- alkyl
- alkoxy
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3212896P | 1996-12-05 | 1996-12-05 | |
| US5095097P | 1997-06-13 | 1997-06-13 | |
| US97605497A | 1997-11-21 | 1997-11-21 | |
| US08/976,054 | 1997-11-21 | ||
| US60/032,128 | 1997-11-21 | ||
| US60/050,950 | 1997-11-21 | ||
| PCT/US1997/022390 WO1998024782A2 (en) | 1996-12-05 | 1997-12-04 | Substituted pyrimidine compounds and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2274063A1 CA2274063A1 (en) | 1998-06-11 |
| CA2274063C true CA2274063C (en) | 2007-09-04 |
Family
ID=27364030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002274063A Expired - Fee Related CA2274063C (en) | 1996-12-05 | 1997-12-04 | Substituted pyrimidine compounds and their use |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0948497A2 (hu) |
| CN (1) | CN1246858A (hu) |
| AR (1) | AR048564A1 (hu) |
| AU (1) | AU733877C (hu) |
| BG (1) | BG65128B1 (hu) |
| BR (1) | BR9713850A (hu) |
| CA (1) | CA2274063C (hu) |
| CZ (1) | CZ296911B6 (hu) |
| HU (1) | HUP0001698A3 (hu) |
| IL (1) | IL130180A0 (hu) |
| NZ (1) | NZ335997A (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100816769B1 (ko) * | 2000-09-06 | 2008-03-26 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 글리코겐 합성효소 키나아제 3의 억제제 |
| DK1427709T3 (da) | 2001-09-21 | 2006-04-03 | Mitsubishi Pharma Corp | 3-substituerede 4-pyrimidonderivater |
| JP4347050B2 (ja) | 2001-09-21 | 2009-10-21 | 田辺三菱製薬株式会社 | ３−置換−４−ピリミドン誘導体 |
| TWI330183B (hu) * | 2001-10-22 | 2010-09-11 | Eisai R&D Man Co Ltd | |
| EP1340759A1 (en) * | 2002-02-28 | 2003-09-03 | Sanofi-Synthelabo | 1-[alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(1H)-one derivatives |
| CN1726209B (zh) | 2002-12-16 | 2011-04-13 | 三菱制药株式会社 | 3-取代的-4-嘧啶酮衍生物 |
| TWI357408B (en) | 2003-03-26 | 2012-02-01 | Mitsubishi Tanabe Pharma Corp | 3-substituted-4-pyrimidone derivatives |
| AU2011317152C1 (en) * | 2010-10-18 | 2016-02-25 | Cerenis Therapeutics Holding Sa | Compounds, compositions and methods useful for cholesterol mobilisation |
| TWI651310B (zh) * | 2014-02-20 | 2019-02-21 | 日商日本煙草產業股份有限公司 | 三化合物及其醫藥用途 |
| CN108137513B (zh) * | 2015-10-29 | 2022-03-01 | Aska 制药株式会社 | 嘧啶衍生物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759176A (fr) * | 1969-11-20 | 1971-05-19 | Sandoz Sa | Derives de la pyrimidine, leur preparation et medicaments contenant cesderives |
| US4438117A (en) * | 1980-09-03 | 1984-03-20 | E. I. Du Pont De Nemours And Company | 2-Substituted thio-4,5-diarylpyrimidines |
| DE3319843A1 (de) * | 1983-06-01 | 1984-12-06 | Ali-Akbar Dipl.-Chem. Dr. 4300 Mülheim Pourzal | Verfahren zur herstellung von pyrimidinen aus nitrilen und alkinen |
| US4500533A (en) * | 1983-06-22 | 1985-02-19 | Eli Lilly And Company | 2,4,5-Triaryl pyrimidines and a method of treating pain, fever, thrombosis, inflammation and arthritis |
| US5077142A (en) * | 1989-04-20 | 1991-12-31 | Ricoh Company, Ltd. | Electroluminescent devices |
| US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
-
1997
- 1997-12-04 AU AU60120/98A patent/AU733877C/en not_active Ceased
- 1997-12-04 CZ CZ0201599A patent/CZ296911B6/cs not_active IP Right Cessation
- 1997-12-04 HU HU0001698A patent/HUP0001698A3/hu unknown
- 1997-12-04 IL IL13018097A patent/IL130180A0/xx unknown
- 1997-12-04 EP EP97954778A patent/EP0948497A2/en not_active Withdrawn
- 1997-12-04 BR BR9713850-9A patent/BR9713850A/pt not_active Application Discontinuation
- 1997-12-04 CA CA002274063A patent/CA2274063C/en not_active Expired - Fee Related
- 1997-12-04 AR ARP970105689A patent/AR048564A1/es not_active Application Discontinuation
- 1997-12-04 NZ NZ335997A patent/NZ335997A/xx unknown
- 1997-12-04 CN CN97181563A patent/CN1246858A/zh active Pending
-
1999
- 1999-06-22 BG BG103512A patent/BG65128B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR048564A1 (es) | 2006-05-10 |
| IL130180A0 (en) | 2000-06-01 |
| HUP0001698A2 (hu) | 2001-04-28 |
| AU6012098A (en) | 1998-06-29 |
| CA2274063A1 (en) | 1998-06-11 |
| BG65128B1 (bg) | 2007-03-30 |
| CZ296911B6 (cs) | 2006-07-12 |
| AU733877B2 (en) | 2001-05-31 |
| NZ335997A (en) | 2001-08-31 |
| BG103512A (en) | 2000-07-31 |
| CZ9902015A3 (cs) | 1999-11-17 |
| HUP0001698A3 (en) | 2002-07-29 |
| BR9713850A (pt) | 2000-02-29 |
| AU733877C (en) | 2003-05-08 |
| EP0948497A2 (en) | 1999-10-13 |
| CN1246858A (zh) | 2000-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6610698B2 (en) | Substituted pyrimidine compounds and methods of use | |
| CA2274093C (en) | Substituted pyrimidinone and pyridinone compounds and their use | |
| US6420385B1 (en) | Substituted pyrimidinone and pyridone compounds and methods of use | |
| WO1998024782A2 (en) | Substituted pyrimidine compounds and their use | |
| CA2315827C (en) | Substituted pyridine and pyridazine compounds and their pharmaceutical use | |
| US6174901B1 (en) | Substituted pyridine and pyridazine compounds and methods of use | |
| CA2271767A1 (en) | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents | |
| CA2466072A1 (en) | Substituted indolizine-like compounds and methods of use | |
| CA2274063C (en) | Substituted pyrimidine compounds and their use | |
| CA2535644A1 (en) | Substituted pyrimdinone derivatives and methods of use | |
| EP1314732A2 (en) | Substituted pyrimidine compounds and their use | |
| MXPA99005168A (en) | Substituted pyrimidine compounds and their use | |
| KR20000069328A (ko) | 치환된 피리미딘 화합물과 그것의 용도 | |
| AU8142901A (en) | Substituted pyrimidinone and pyridone compounds and methods of use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |