CA2274055A1 - Derives du n-piperazine-1-ylphenyl-benzamide - Google Patents
Derives du n-piperazine-1-ylphenyl-benzamide Download PDFInfo
- Publication number
- CA2274055A1 CA2274055A1 CA002274055A CA2274055A CA2274055A1 CA 2274055 A1 CA2274055 A1 CA 2274055A1 CA 002274055 A CA002274055 A CA 002274055A CA 2274055 A CA2274055 A CA 2274055A CA 2274055 A1 CA2274055 A1 CA 2274055A1
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- methoxy
- 6alkyl
- methylpiperazin
- 6alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Cette invention concerne de nouveaux dérivés de carboxamide ayant une activité sur le système nerveux central (SNC), des procédés de préparation de ces nouveaux composés ainsi que leur utilisation en tant que médicaments.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9626376.9A GB9626376D0 (en) | 1996-12-19 | 1996-12-19 | Novel compounds |
GB9700902.1 | 1997-01-17 | ||
GB9626376.9 | 1997-01-17 | ||
GBGB9700902.1A GB9700902D0 (en) | 1997-01-17 | 1997-01-17 | Novel compounds |
PCT/EP1997/007160 WO1998027058A2 (fr) | 1996-12-19 | 1997-12-15 | Nouveaux composes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2274055A1 true CA2274055A1 (fr) | 1998-06-25 |
Family
ID=26310680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002274055A Abandoned CA2274055A1 (fr) | 1996-12-19 | 1997-12-15 | Derives du n-piperazine-1-ylphenyl-benzamide |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0946551A2 (fr) |
JP (1) | JP2001506995A (fr) |
CA (1) | CA2274055A1 (fr) |
WO (1) | WO1998027058A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2288172A1 (fr) * | 1997-04-18 | 1998-10-29 | Smithkline Beecham P.L.C. | Aryl bicyclique ou noyau heterocyclique bicyclique contenant des composes presentant une activite antagoniste combinee contre les recepteurs 5ht1a, 5ht1b et 5ht1d |
IL133870A0 (en) * | 1997-07-11 | 2001-04-30 | Smithkline Beecham Plc | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation |
GB9803411D0 (en) * | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
EP1112270B1 (fr) * | 1998-09-10 | 2007-03-21 | F. Hoffmann-La Roche Ag | Dihydrobenzodioxine carboxamide et derives de cetone utilises comme antagonistes du recepteur 5-ht4 |
GB9820113D0 (en) | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
MXPA02003175A (es) | 1999-09-25 | 2002-09-30 | Smithkline Beecham Plc | Derivados de piperazina como antagonsitas de 5-ht1b. |
CA2432713C (fr) | 2000-12-22 | 2009-10-27 | Ishihara Sangyo Kaisha, Ltd. | Derives d'aniline ou sels de ceux-ci, ainsi qu'inhibiteurs de production de cytokine contenant ces derives |
AU2002217742B2 (en) | 2001-01-16 | 2008-02-21 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
MXPA03006268A (es) | 2001-01-16 | 2003-09-22 | Astrazeneca Ab | Compuestos terapeuticos de cromano. |
GB0106586D0 (en) * | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
SE0103644D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
BR112012024380A2 (pt) | 2010-03-25 | 2015-09-15 | Glaxosmithkline Llc | compostos químicos |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
FR2693201B1 (fr) * | 1992-07-01 | 1994-08-19 | Inst Nat Sante Rech Med | Nouveaux polypeptides ayant une activité de récepteur sérotoninergique, acides nucléiques codant pour ces polyptides et utilisations. |
FR2699533A1 (fr) * | 1992-12-21 | 1994-06-24 | Mouhtaram Mohamed | Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications. |
TW240217B (fr) * | 1992-12-30 | 1995-02-11 | Glaxo Group Ltd | |
GB2273930A (en) * | 1992-12-30 | 1994-07-06 | Glaxo Group Ltd | Benzanilide derivatives |
DK0689536T3 (da) * | 1993-03-16 | 2001-07-30 | Pfizer | Naphthalenderivater |
GB2276165A (en) * | 1993-03-17 | 1994-09-21 | Glaxo Group Ltd | Aniline and benzanilide compounds. |
GB2276164A (en) * | 1993-03-17 | 1994-09-21 | Glaxo Group Ltd | Aniline and benzanilide derivatives |
US5834471A (en) * | 1993-08-06 | 1998-11-10 | Smithkline Beecham P.L.C. | Amide derivatives as 5HT1D receptor antagonists |
EP0724580A1 (fr) * | 1993-10-19 | 1996-08-07 | Smithkline Beecham Plc | Derives de benzanilide en tant qu'antagonistes du recepteur de 5ht-1d |
EP0661266A1 (fr) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Composés cycliques aminés substitués comme 5HT2 antagonistes |
WO1995017888A1 (fr) * | 1993-12-30 | 1995-07-06 | Smithkline Beecham Corporation | Hexanamides de phenylmethyle et leur utilisation |
-
1997
- 1997-12-15 EP EP97954435A patent/EP0946551A2/fr not_active Withdrawn
- 1997-12-15 CA CA002274055A patent/CA2274055A1/fr not_active Abandoned
- 1997-12-15 JP JP52734898A patent/JP2001506995A/ja active Pending
- 1997-12-15 WO PCT/EP1997/007160 patent/WO1998027058A2/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1998027058A3 (fr) | 1998-08-20 |
EP0946551A2 (fr) | 1999-10-06 |
WO1998027058A2 (fr) | 1998-06-25 |
JP2001506995A (ja) | 2001-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |