CA2271652A1 - Element compact compose d'une pluralite de matrices poreuses en cellulose (pcm), son procede de fabrication et d'utilisation - Google Patents

Element compact compose d'une pluralite de matrices poreuses en cellulose (pcm), son procede de fabrication et d'utilisation Download PDF

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Publication number
CA2271652A1
CA2271652A1 CA002271652A CA2271652A CA2271652A1 CA 2271652 A1 CA2271652 A1 CA 2271652A1 CA 002271652 A CA002271652 A CA 002271652A CA 2271652 A CA2271652 A CA 2271652A CA 2271652 A1 CA2271652 A1 CA 2271652A1
Authority
CA
Canada
Prior art keywords
release
pcms
compact member
active compound
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002271652A
Other languages
English (en)
Inventor
Torkel Gren
Christer Nystrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9604124A external-priority patent/SE9604124D0/xx
Application filed by Individual filed Critical Individual
Publication of CA2271652A1 publication Critical patent/CA2271652A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fertilizers (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

L'invention concerne un élément compact composé d'une pluralité de matrices poreuses en cellulose (PCM) et permettant de libérer de façon prolongée un composé actif situé dans les pores desdites matrices avec un agent modifiant la libération. Le caractère friable de cet élément compact est inférieur à 2,1 % et le temps de désintégration in vitro dudit élément compact est inférieur à 240 minutes. On fabrique cet élément compact par exposition d'une pluralité de matrices poreuses (PCM) à un composé actif et à un agent modifiant la libération, dans une séquence ou dans un mélange éventuels, pendant une durée suffisante au remplissage des pores dans lesdites matrices jusqu'à un niveau présélectionné, par ledit composé actif et par ledit agent modifiant la libération. On rend ensuite ces matrices compactes jusqu'à obtention de la forme souhaitée. L'invention concerne, de plus, l'utilisation d'éléments compacts pour l'administration d'un médicament.
CA002271652A 1996-11-12 1997-11-12 Element compact compose d'une pluralite de matrices poreuses en cellulose (pcm), son procede de fabrication et d'utilisation Abandoned CA2271652A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9604124A SE9604124D0 (sv) 1996-11-12 1996-11-12 Compact member, method of manufacturing and use thereof
SE9604124-9 1996-11-12
US3172396P 1996-11-25 1996-11-25
US60/031,723 1996-11-25
PCT/SE1997/001901 WO1998020858A1 (fr) 1996-11-12 1997-11-12 Element compact compose d'une pluralite de matrices poreuses en cellulose (pcm), son procede de fabrication et d'utilisation

Publications (1)

Publication Number Publication Date
CA2271652A1 true CA2271652A1 (fr) 1998-05-22

Family

ID=26662794

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002271652A Abandoned CA2271652A1 (fr) 1996-11-12 1997-11-12 Element compact compose d'une pluralite de matrices poreuses en cellulose (pcm), son procede de fabrication et d'utilisation

Country Status (6)

Country Link
EP (1) EP0941069A1 (fr)
JP (1) JP2001503766A (fr)
AU (1) AU728754B2 (fr)
CA (1) CA2271652A1 (fr)
NZ (1) NZ335737A (fr)
WO (1) WO1998020858A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535353A (ja) * 1999-01-29 2002-10-22 ロザン ファルマ ゲゼルシャフトミットベシュレンクテルハフツンク 医薬品組成物
AU775995B2 (en) * 1999-06-07 2004-08-19 Nycomed Gmbh Novel preparation and administration form comprising an acid-labile active compound
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
US7001475B2 (en) 2001-12-11 2006-02-21 3M Innovative Properties Company Film structures and methods of making film structures
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20040109889A1 (en) 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
DE102005028696A1 (de) * 2005-06-21 2006-12-28 Pulmotec Gmbh Verwendung eines Hilfsstoffs zur Einstellung der Abrasionsfestigkeit eines verfestigten Wirkstoffpräparats
EP2191848A4 (fr) * 2007-08-31 2013-05-15 Daiichi Sankyo Co Ltd Préparation à libération prolongée et procédé de fabrication de celle-ci

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002017D0 (sv) * 1990-06-06 1990-06-06 Kabivitrum Ab Process for manufacture of matrices
AU8050791A (en) * 1990-06-20 1992-01-07 Advanced Polymer Systems Inc. Compositions and methods for the controlled release of soluble active substances
SE9301220D0 (sv) * 1993-04-14 1993-04-14 Kabi Pharmacia Ab Manufacturing matrices

Also Published As

Publication number Publication date
WO1998020858A1 (fr) 1998-05-22
NZ335737A (en) 2000-09-29
EP0941069A1 (fr) 1999-09-15
AU728754B2 (en) 2001-01-18
JP2001503766A (ja) 2001-03-21
AU5075898A (en) 1998-06-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued