CA2269335C - Platelet substitutes and conjugation methods suitable for their preparation - Google Patents

Platelet substitutes and conjugation methods suitable for their preparation Download PDF

Info

Publication number
CA2269335C
CA2269335C CA2269335A CA2269335A CA2269335C CA 2269335 C CA2269335 C CA 2269335C CA 2269335 A CA2269335 A CA 2269335A CA 2269335 A CA2269335 A CA 2269335A CA 2269335 C CA2269335 C CA 2269335C
Authority
CA
Canada
Prior art keywords
fibrinogen
albumin
spacer
microcapsules
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2269335A
Other languages
English (en)
French (fr)
Other versions
CA2269335A1 (en
Inventor
David Heath
Sarah Margaret Middleton
Roy Harris
Nicola Jane Church
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Quadrant Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26310263&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2269335(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9621886.2A external-priority patent/GB9621886D0/en
Priority claimed from GBGB9702652.0A external-priority patent/GB9702652D0/en
Application filed by Quadrant Drug Delivery Ltd filed Critical Quadrant Drug Delivery Ltd
Publication of CA2269335A1 publication Critical patent/CA2269335A1/en
Application granted granted Critical
Publication of CA2269335C publication Critical patent/CA2269335C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
CA2269335A 1996-10-21 1997-10-17 Platelet substitutes and conjugation methods suitable for their preparation Expired - Fee Related CA2269335C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9621886.2A GB9621886D0 (en) 1996-10-21 1996-10-21 Microparticles and their therapeutic use
GB9621886.2 1996-10-21
GB9702652.0 1997-02-10
GBGB9702652.0A GB9702652D0 (en) 1997-02-10 1997-02-10 Conjugates and their preparation
PCT/GB1997/002877 WO1998017319A2 (en) 1996-10-21 1997-10-17 Platelet substitutes and conjugation methods suitable for their preparation

Publications (2)

Publication Number Publication Date
CA2269335A1 CA2269335A1 (en) 1998-04-30
CA2269335C true CA2269335C (en) 2010-05-25

Family

ID=26310263

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2269335A Expired - Fee Related CA2269335C (en) 1996-10-21 1997-10-17 Platelet substitutes and conjugation methods suitable for their preparation

Country Status (10)

Country Link
US (1) US5977313A (enExample)
EP (1) EP1028752B1 (enExample)
JP (1) JP2001504813A (enExample)
AR (1) AR008680A1 (enExample)
AT (1) ATE284714T1 (enExample)
AU (1) AU718956B2 (enExample)
CA (1) CA2269335C (enExample)
DE (1) DE69731985T2 (enExample)
ES (1) ES2232862T3 (enExample)
WO (1) WO1998017319A2 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391343B1 (en) 1991-01-15 2002-05-21 Hemosphere, Inc. Fibrinogen-coated particles for therapeutic use
US6264988B1 (en) 1997-06-05 2001-07-24 Hemosphere, Inc. Fibrinogen-coated microspheres
GB9724143D0 (en) * 1997-11-14 1998-01-14 Andaris Ltd Pharmaceutical conjugate
US20030021777A1 (en) * 1998-02-20 2003-01-30 Roy Harris Product comprising bound fibrinogen and thrombin for use in wound therapy or surgical repair
GB9825105D0 (en) * 1998-11-16 1999-01-13 Andaris Ltd Pharamaceutical conjugates
GB9827813D0 (en) * 1998-12-17 1999-02-10 Andaris Ltd Pharmaceutical conjugates
DE19926475A1 (de) * 1999-06-10 2000-12-14 Ktb Tumorforschungs Gmbh Träger-Pharmaka-Konjugate
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
AU2002330139A1 (en) * 2001-10-03 2003-04-14 Vanderbilt University In vivo panning for ligands to radiation-induced molecules
US7306925B2 (en) 2001-11-09 2007-12-11 Vanderbilt University Phage antibodies to radiation-inducible neoantigens
GB0323378D0 (en) * 2003-10-07 2003-11-05 Univ Leicester Therapeutic agent
GB0516091D0 (en) * 2005-08-04 2005-09-14 Haemostatix Ltd Therapeutic agent
US20080015145A1 (en) * 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
US20110077202A1 (en) * 2008-05-16 2011-03-31 Bayer Healthcare Llc Targeted Coagulation Factors and Method of Using the Same
US9119897B2 (en) 2009-05-28 2015-09-01 Profibrix B.V. Dry powder fibrin sealant
GB201101740D0 (en) * 2011-02-01 2011-03-16 Haemostatix Ltd Therapeutic agents with improved fibrinogen binding
WO2013019730A1 (en) 2011-07-29 2013-02-07 The Washington University Antibodies to tip-1 and grp78
GB201201751D0 (en) 2012-02-01 2012-03-14 Haemostatix Ltd Haemostatic wound dressing
US20130202675A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and methods for the fabrication of tissue patches
GB201204868D0 (en) 2012-03-20 2012-05-02 San Raffaele Centro Fond Peptides
WO2016014939A1 (en) 2014-07-24 2016-01-28 Washington University Compositions targeting radiation-induced molecules and methods of use thereof
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
WO2017027378A1 (en) 2015-08-07 2017-02-16 Xcede Technologies, Inc. Adhesive compositions and related methods
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
CN107686507B (zh) * 2016-08-05 2021-02-12 首都医科大学 Rgds-阿霉素,其合成,活性和应用
CN107686508B (zh) * 2016-08-05 2021-02-12 首都医科大学 阿霉素-rgds,其合成,活性和应用
WO2018148595A1 (en) 2017-02-10 2018-08-16 Washington University Antibodies to tip1 and methods of use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
US5069936A (en) * 1987-06-25 1991-12-03 Yen Richard C K Manufacturing protein microspheres
AU3149289A (en) * 1988-03-18 1989-09-21 Rockefeller University, The Method and agent for inhibiting the binding of human polymorphonuclear leukocytes to endothelium and compositions therefor
DE68924783T2 (de) * 1988-09-30 1996-03-28 Neorx Corp Wässrige additivsysteme, verfahren und polymerteilchen.
DE69118861T2 (de) * 1991-01-10 1996-09-05 Basf Corp Verfahren zur Vernetzen von Gelatine und Aufnahme eines Materials
US5616311A (en) * 1991-01-15 1997-04-01 Hemosphere, Inc. Non-crosslinked protein particles for therapeutic and diagnostic use
US5725804A (en) * 1991-01-15 1998-03-10 Hemosphere, Inc. Non-crosslinked protein particles for therapeutic and diagnostic use
ATE147976T1 (de) * 1991-01-15 1997-02-15 Hemosphere Inc Protein nanomatrizen und verfahren zur herstellung
AU1461592A (en) * 1991-02-07 1992-09-07 Fibratek, Inc. Fibrinogen based adhesive
WO1992013547A1 (en) * 1991-02-07 1992-08-20 Alexander Mellon Eaton Drug delivery composition and method of using the same
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
WO1994013692A1 (en) * 1992-12-10 1994-06-23 Regents Of The University Of Minnesota Polypeptides useful for treating inflammatory disorders
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
DE69529917T2 (de) * 1994-12-16 2003-12-11 Elan Drug Delivery Ltd., Ruddington Vernetzte mikropartikel und ihre verwendung als arzneiträger
EP0727225A3 (en) * 1995-02-14 1997-01-15 Sonus Pharma Inc Compositions and methods for directed ultrasonic imaging
EP0831793A4 (en) * 1995-06-06 2000-11-15 Hemosphere Inc PROTEIN PARTICLES FOR THERAPEUTIC AND DIAGNOSTIC USE

Also Published As

Publication number Publication date
EP1028752B1 (en) 2004-12-15
ES2232862T3 (es) 2005-06-01
WO1998017319A3 (en) 1998-06-11
JP2001504813A (ja) 2001-04-10
DE69731985D1 (de) 2005-01-20
AU718956B2 (en) 2000-05-04
AR008680A1 (es) 2000-02-09
ATE284714T1 (de) 2005-01-15
WO1998017319A2 (en) 1998-04-30
CA2269335A1 (en) 1998-04-30
DE69731985T2 (de) 2005-12-29
EP1028752A2 (en) 2000-08-23
US5977313A (en) 1999-11-02
AU4713597A (en) 1998-05-15

Similar Documents

Publication Publication Date Title
US5977313A (en) Platelet substitutes and conjugation methods suitable for their preparation
AU692019B2 (en) Cross-linked microparticles and their use as therapeutic vehicles
US6410517B1 (en) Targeted gene delivery system
US5955108A (en) Cross-linked microparticles and their use as therapeutic vehicles
US4671958A (en) Antibody conjugates for the delivery of compounds to target sites
EP0088695B1 (en) Antibody conjugates
Absar et al. Bio-responsive delivery of tissue plasminogen activator for localized thrombolysis
US20130029913A1 (en) Artificial platelets
EP2670441B1 (en) Therapeutic agents with improved fibrinogen binding
EP1047452B1 (en) Conjugates comprising two active agents
JPH09504790A (ja) 化学的触媒作用および細胞受容体活性化のための生化学的活性物質
Zhang et al. A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases
MXPA99003677A (en) Platelet substitutes and conjugation methods suitable for their preparation
CN1240364A (zh) 血小板替代物和适于其制备的缀合方法
Siouve et al. A general strategy for site-oriented protein anchoring on metal–organic frameworks: HER2-targeted delivery using an engineered antibody fragment
WO2000035487A1 (en) Pharmaceutical conjugates comprising two active agents
WO2000029028A1 (en) Pharmaceutical conjugates of glycoproteins and insoluble carriers
US20150343085A1 (en) Direct Utilization of Plasma Proteins for the In Vivo Assembly of Protein-Drug/Imaging Agent Conjugates, Nanocarriers and Coatings for Biomaterials
JP2002517472A (ja) レクチンおよび血液凝固因子からなる結合体
US20040235719A1 (en) Soluble protein-polymer systems for drug delivery

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20141017