CA2268756A1 - Composes de piperidine - Google Patents

Composes de piperidine Download PDF

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Publication number
CA2268756A1
CA2268756A1 CA002268756A CA2268756A CA2268756A1 CA 2268756 A1 CA2268756 A1 CA 2268756A1 CA 002268756 A CA002268756 A CA 002268756A CA 2268756 A CA2268756 A CA 2268756A CA 2268756 A1 CA2268756 A1 CA 2268756A1
Authority
CA
Canada
Prior art keywords
compound
carbon atoms
substituted
alkyl
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002268756A
Other languages
English (en)
Inventor
Choung U. Kim
Matthew A. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2268756A1 publication Critical patent/CA2268756A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés. Ces composés comprennent généralement un groupe acide, un groupe basique, un groupe amino substitué ou N-acyle et un groupe possédant une fraction alkane éventuellement hydroxylée. Elle concerne également des compositions pharmaceutiques contenant ces composés inhibiteurs. Elle concerne également des procédés d'inhibition de neuramidinase dans des spécimens susceptibles de contenir neuraminidase. Elle concerne, de plus, des matériaux antigéniques, des polymères, des anticorps, des conjugués de ces composés comportant des marquages, ainsi que des procédés servant à détecter une activité de neuraminidase.
CA002268756A 1996-10-21 1997-10-17 Composes de piperidine Abandoned CA2268756A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2890196P 1996-10-21 1996-10-21
US60/028,901 1996-10-21
PCT/US1997/018193 WO1998017647A1 (fr) 1996-10-21 1997-10-17 Composes de piperidine

Publications (1)

Publication Number Publication Date
CA2268756A1 true CA2268756A1 (fr) 1998-04-30

Family

ID=21846142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268756A Abandoned CA2268756A1 (fr) 1996-10-21 1997-10-17 Composes de piperidine

Country Status (7)

Country Link
EP (1) EP0938475A1 (fr)
JP (1) JP2001502690A (fr)
KR (1) KR20000052702A (fr)
CN (1) CN1238762A (fr)
AU (1) AU743333B2 (fr)
CA (1) CA2268756A1 (fr)
WO (1) WO1998017647A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
AU1476900A (en) * 1998-11-13 2000-06-05 Gilead Sciences, Inc. 1,4,5,6-tetrahydro-pyridazine derivatives, their preparation and their use as neuraminidase inhibitors
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
AU2039301A (en) * 1999-10-19 2001-04-30 Abbott Laboratories Neuraminidase inhibitors
US6518299B1 (en) 2000-10-20 2003-02-11 Biocryst Pharmaceuticals, Inc. Substituted pyrrolidine compounds useful as neuraminidase inhibitors
BR112017013858A2 (pt) 2014-12-26 2018-02-27 Univ Emory n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
MX2020005392A (es) 2017-12-07 2020-12-07 Univ Emory N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282950B6 (sk) * 1990-04-24 2003-01-09 Biota Scientific Management Pty Ltd Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze
JPH0489481A (ja) * 1990-07-31 1992-03-23 Microbial Chem Res Found 新規な抗ウイルス性物質シアスタチンｂ誘導体およびそれらの製造法
WO1992006691A1 (fr) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Composes anti-viraux qui lient le site actif de la neuraminidase de la grippe et presentent une activite in vivo contre l'orthomixovirus et le paramyxovirus
CA2081068C (fr) * 1991-10-23 2005-11-29 Laurence Mark Von Itzstein Derives antiviraux de 2-desoxy-2,3-deshydro a substituant en 4 de l'acide .alpha.-d-neuraminique
BR9607098A (pt) * 1995-02-27 1997-11-04 Gilead Sciences Inc Novos inibidores seletivos de neuraminidas virais ou bacterianas

Also Published As

Publication number Publication date
JP2001502690A (ja) 2001-02-27
WO1998017647A1 (fr) 1998-04-30
CN1238762A (zh) 1999-12-15
KR20000052702A (ko) 2000-08-25
EP0938475A1 (fr) 1999-09-01
AU743333B2 (en) 2002-01-24
AU4979597A (en) 1998-05-15

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Legal Events

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FZDE Dead