CA2268749A1 - Conservation structurelle et fonctionnelle du gene d'horloge clk-1 chez c. elegans - Google Patents

Conservation structurelle et fonctionnelle du gene d'horloge clk-1 chez c. elegans Download PDF

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Publication number
CA2268749A1
CA2268749A1 CA002268749A CA2268749A CA2268749A1 CA 2268749 A1 CA2268749 A1 CA 2268749A1 CA 002268749 A CA002268749 A CA 002268749A CA 2268749 A CA2268749 A CA 2268749A CA 2268749 A1 CA2268749 A1 CA 2268749A1
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Prior art keywords
clk
gene
leu
ala
ser
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Abandoned
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CA002268749A
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English (en)
Inventor
Jonathan Ewbank
Thomas Barnes
Bernard Lakowski
Siegfried Hekimi
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McGill University
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Individual
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Publication of CA2268749A1 publication Critical patent/CA2268749A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • C07K14/43545—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes from Caenorhabditis
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0335—Genetically modified worms
    • A01K67/0336—Genetically modified Nematodes, e.g. Caenorhabditis elegans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention se rapporte à un gène clk-1 ayant une fonction au plan de la physiologie cellulaire en rapport avec le rythme de développement et la longévité; l'invention se rapporte également à des mutants de clk-1 vivant plus longtemps et possédant un métabolisme cellulaire modifié par rapport au type sauvage. En outre, l'invention concerne une méthode de diagnostic et/ou de pronostic du cancer chez un patient; ladite méthode comprend deux stages qui consistent (a) à obtenir un échantillon du tissu d'un patient et (b) à analyser l'ADN de l'échantillon de tissu obtenu au stade (a) pour déterminer si le gène humain clk-1 est modifié, la modification du gène humain clk-1 indiquant la présence d'un cancer. L'invention propose finalement une méthode de traitement d'états pathologiques provoquant un ralentissement du rythme physiologique d'un tissu et/ou d'un organe chez un patient.
CA002268749A 1996-10-21 1997-10-17 Conservation structurelle et fonctionnelle du gene d'horloge clk-1 chez c. elegans Abandoned CA2268749A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2897796P 1996-10-21 1996-10-21
US60/028,977 1996-10-21
US3319696P 1996-12-18 1996-12-18
US60/033,196 1996-12-18
PCT/CA1997/000768 WO1998017823A1 (fr) 1996-10-21 1997-10-17 CONSERVATION STRUCTURELLE ET FONCTIONNELLE DU GENE D'HORLOGE clk-1 CHEZ $i(C. ELEGANS)

Publications (1)

Publication Number Publication Date
CA2268749A1 true CA2268749A1 (fr) 1998-04-30

Family

ID=26704340

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268749A Abandoned CA2268749A1 (fr) 1996-10-21 1997-10-17 Conservation structurelle et fonctionnelle du gene d'horloge clk-1 chez c. elegans

Country Status (9)

Country Link
EP (1) EP0932701A1 (fr)
JP (1) JP2001502181A (fr)
KR (1) KR20000052654A (fr)
CN (1) CN1234077A (fr)
AU (1) AU743527B2 (fr)
BR (1) BR9712368A (fr)
CA (1) CA2268749A1 (fr)
NZ (1) NZ335335A (fr)
WO (1) WO1998017823A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058671A2 (fr) * 1998-05-08 1999-11-18 Research Corporation Technologies, Inc. Homologues du gene d'assurance de longevite des levures, lag1, d'origine humaine ou issus de nematodes
US8642284B1 (en) 1999-12-15 2014-02-04 Massachusetts Institute Of Technology Methods for identifying agents that alter NAD-dependent deacetylation activity of a SIR2 protein
US7452664B2 (en) 1999-12-15 2008-11-18 Massachusetts Institute Of Technology Methods for identifying agents which alter histone protein acetylation
JP2004500878A (ja) * 2000-06-22 2004-01-15 マックギル　ユニヴァーシティー Ｃｌｋ−２、ｃｅｘ−７およびｃｏｑ−４遺伝子ならびにその使用
US7572575B2 (en) 2000-12-13 2009-08-11 Massachusetts Institute Of Technology SIR2 activity
US20070099830A1 (en) 2005-04-21 2007-05-03 Massachusetts Institute Of Technology Sirt4 activities
CN103088021B (zh) * 2011-10-31 2015-08-05 中国科学院动物研究所 miR-45调控线虫寿命的应用和方法
FR3012739A1 (fr) 2013-11-07 2015-05-08 Centre Nat Rech Scient Sno arn, compositions et utilisations
JP7186457B2 (ja) * 2019-08-01 2022-12-09 国立大学法人 熊本大学 線虫を用いた個体レベルの健康寿命の評価系

Also Published As

Publication number Publication date
JP2001502181A (ja) 2001-02-20
BR9712368A (pt) 2000-01-25
AU4612897A (en) 1998-05-15
WO1998017823A1 (fr) 1998-04-30
EP0932701A1 (fr) 1999-08-04
AU743527B2 (en) 2002-01-31
CN1234077A (zh) 1999-11-03
NZ335335A (en) 2000-11-24
KR20000052654A (ko) 2000-08-25

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