CA2262588A1 - Electromagnetic cardiac biostimulation - Google Patents
Electromagnetic cardiac biostimulation Download PDFInfo
- Publication number
- CA2262588A1 CA2262588A1 CA002262588A CA2262588A CA2262588A1 CA 2262588 A1 CA2262588 A1 CA 2262588A1 CA 002262588 A CA002262588 A CA 002262588A CA 2262588 A CA2262588 A CA 2262588A CA 2262588 A1 CA2262588 A1 CA 2262588A1
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- irradiating
- heart
- source
- catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000000747 cardiac effect Effects 0.000 title description 6
- 210000001519 tissue Anatomy 0.000 claims abstract description 129
- 238000000034 method Methods 0.000 claims abstract description 95
- 230000002107 myocardial effect Effects 0.000 claims abstract description 76
- 230000005855 radiation Effects 0.000 claims abstract description 73
- 206010061216 Infarction Diseases 0.000 claims abstract description 65
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 59
- 230000007574 infarction Effects 0.000 claims abstract description 57
- 230000001678 irradiating effect Effects 0.000 claims abstract description 51
- 230000000694 effects Effects 0.000 claims abstract description 25
- 210000004413 cardiac myocyte Anatomy 0.000 claims abstract description 24
- 230000009467 reduction Effects 0.000 claims abstract description 12
- 230000008929 regeneration Effects 0.000 claims abstract description 11
- 238000011069 regeneration method Methods 0.000 claims abstract description 11
- 210000003470 mitochondria Anatomy 0.000 claims abstract description 9
- 210000002216 heart Anatomy 0.000 claims description 112
- 230000003287 optical effect Effects 0.000 claims description 46
- 230000000302 ischemic effect Effects 0.000 claims description 36
- 239000000523 sample Substances 0.000 claims description 32
- 230000001427 coherent effect Effects 0.000 claims description 21
- 230000035899 viability Effects 0.000 claims description 21
- 210000005003 heart tissue Anatomy 0.000 claims description 18
- 239000012528 membrane Substances 0.000 claims description 17
- RNBGYGVWRKECFJ-ZXXMMSQZSA-N alpha-D-fructofuranose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O RNBGYGVWRKECFJ-ZXXMMSQZSA-N 0.000 claims description 15
- 210000000038 chest Anatomy 0.000 claims description 15
- 229940025237 fructose 1,6-diphosphate Drugs 0.000 claims description 15
- 230000000250 revascularization Effects 0.000 claims description 13
- 230000001764 biostimulatory effect Effects 0.000 claims description 12
- 229910052724 xenon Inorganic materials 0.000 claims description 12
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 12
- 238000003780 insertion Methods 0.000 claims description 11
- 230000037431 insertion Effects 0.000 claims description 11
- 206010063837 Reperfusion injury Diseases 0.000 claims description 10
- 210000000115 thoracic cavity Anatomy 0.000 claims description 9
- 210000004351 coronary vessel Anatomy 0.000 claims description 8
- 239000002516 radical scavenger Substances 0.000 claims description 8
- 108010068426 Contractile Proteins Proteins 0.000 claims description 7
- 102000002585 Contractile Proteins Human genes 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 230000004907 flux Effects 0.000 claims description 5
- 210000002976 pectoralis muscle Anatomy 0.000 claims description 5
- 210000000709 aorta Anatomy 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 210000005242 cardiac chamber Anatomy 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 241000700159 Rattus Species 0.000 description 66
- 238000002474 experimental method Methods 0.000 description 51
- 210000004165 myocardium Anatomy 0.000 description 46
- 210000004027 cell Anatomy 0.000 description 28
- 208000010125 myocardial infarction Diseases 0.000 description 23
- 210000004369 blood Anatomy 0.000 description 17
- 239000008280 blood Substances 0.000 description 17
- 238000011282 treatment Methods 0.000 description 16
- 241000699670 Mus sp. Species 0.000 description 11
- 210000003205 muscle Anatomy 0.000 description 9
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 description 8
- 101710205037 Sarafotoxin Proteins 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- 210000004204 blood vessel Anatomy 0.000 description 7
- 230000004217 heart function Effects 0.000 description 7
- 230000006698 induction Effects 0.000 description 7
- 208000028867 ischemia Diseases 0.000 description 7
- 231100000252 nontoxic Toxicity 0.000 description 7
- 230000003000 nontoxic effect Effects 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 210000002027 skeletal muscle Anatomy 0.000 description 7
- 229940123457 Free radical scavenger Drugs 0.000 description 6
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 230000035876 healing Effects 0.000 description 6
- 238000002513 implantation Methods 0.000 description 6
- 210000005240 left ventricle Anatomy 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 6
- 230000010410 reperfusion Effects 0.000 description 6
- 231100000241 scar Toxicity 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 5
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 5
- 102100036912 Desmin Human genes 0.000 description 5
- 108010044052 Desmin Proteins 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 230000001120 cytoprotective effect Effects 0.000 description 5
- 210000005045 desmin Anatomy 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000004083 survival effect Effects 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 102000001105 Phosphofructokinases Human genes 0.000 description 4
- 108010069341 Phosphofructokinases Proteins 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000036770 blood supply Effects 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000013307 optical fiber Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 206010019280 Heart failures Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 3
- 206010000891 acute myocardial infarction Diseases 0.000 description 3
- 230000033115 angiogenesis Effects 0.000 description 3
- 206010003119 arrhythmia Diseases 0.000 description 3
- 230000006793 arrhythmia Effects 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 238000007887 coronary angioplasty Methods 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000002647 laser therapy Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000003387 muscular Effects 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 238000004321 preservation Methods 0.000 description 3
- PKDBCJSWQUOKDO-UHFFFAOYSA-M 2,3,5-triphenyltetrazolium chloride Chemical compound [Cl-].C1=CC=CC=C1C(N=[N+]1C=2C=CC=CC=2)=NN1C1=CC=CC=C1 PKDBCJSWQUOKDO-UHFFFAOYSA-M 0.000 description 2
- 102000004420 Creatine Kinase Human genes 0.000 description 2
- 108010042126 Creatine kinase Proteins 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000001467 acupuncture Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000006538 anaerobic glycolysis Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000008033 biological extinction Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000002064 heart cell Anatomy 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000000876 intercostal muscle Anatomy 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 238000013532 laser treatment Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 230000003562 morphometric effect Effects 0.000 description 2
- 238000013425 morphometry Methods 0.000 description 2
- 230000009756 muscle regeneration Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 230000001114 myogenic effect Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000001562 sternum Anatomy 0.000 description 2
- 210000000779 thoracic wall Anatomy 0.000 description 2
- 230000002537 thrombolytic effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 210000003934 vacuole Anatomy 0.000 description 2
- 210000002620 vena cava superior Anatomy 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 101100055563 Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094) aneA gene Proteins 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 208000001778 Coronary Occlusion Diseases 0.000 description 1
- 206010011086 Coronary artery occlusion Diseases 0.000 description 1
- 108050009340 Endothelin Proteins 0.000 description 1
- 102000002045 Endothelin Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 208000006083 Hypokinesia Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100345589 Mus musculus Mical1 gene Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 230000001451 cardiotoxic effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000002595 cold damage Effects 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 210000001174 endocardium Anatomy 0.000 description 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002839 fiber optic waveguide Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 230000006545 glycolytic metabolism Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000001308 heart ventricle Anatomy 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 230000004171 ischemic cascade Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 210000003098 myoblast Anatomy 0.000 description 1
- 230000010016 myocardial function Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 230000000886 photobiology Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000026313 regulation of carbohydrate metabolic process Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000003270 subclavian artery Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 208000003663 ventricular fibrillation Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
- A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
- A61B5/283—Invasive
- A61B5/287—Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6885—Monitoring or controlling sensor contact pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
- A61B8/0841—Clinical applications involving detecting or locating foreign bodies or organic structures for locating instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/005—Flexible endoscopes
- A61B1/0051—Flexible endoscopes with controlled bending of insertion part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3403—Needle locating or guiding means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00106—Sensing or detecting at the treatment site ultrasonic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
- A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00292—Surgical instruments, devices or methods for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
- A61B2017/003—Steerable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B2017/22005—Effects, e.g. on tissue
- A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
- A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00392—Transmyocardial revascularisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2255—Optical elements at the distal end of probe tips
- A61B2018/2272—Optical elements at the distal end of probe tips with reflective or refractive surfaces for deflecting the beam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2051—Electromagnetic tracking systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
- A61B2090/3958—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI emitting a signal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
- A61M2025/0166—Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Radiology & Medical Imaging (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Mechanical Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Robotics (AREA)
- Vascular Medicine (AREA)
- Physiology (AREA)
- Cardiology (AREA)
- Human Computer Interaction (AREA)
- Radiation-Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL118968 | 1996-07-28 | ||
| IL11896896A IL118968A (en) | 1996-07-28 | 1996-07-28 | Apparatus for biostimulation of myocardial tissue by electromagnetic wave radiation |
| US3470397P | 1997-01-03 | 1997-01-03 | |
| US3470497P | 1997-01-03 | 1997-01-03 | |
| US60/034,704 | 1997-01-03 | ||
| US60/034,703 | 1997-01-03 | ||
| PCT/IL1997/000011 WO1997025101A2 (en) | 1996-01-08 | 1997-01-08 | Methods and apparatus for myocardial revascularization |
| WOPCT/IL97/00011 | 1997-01-08 | ||
| PCT/IL1997/000257 WO1998004321A1 (en) | 1996-07-28 | 1997-07-28 | Electromagnetic cardiac biostimulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2262588A1 true CA2262588A1 (en) | 1998-02-05 |
Family
ID=27452386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002262588A Abandoned CA2262588A1 (en) | 1996-07-28 | 1997-07-28 | Electromagnetic cardiac biostimulation |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0930917B1 (enExample) |
| JP (2) | JP2002511774A (enExample) |
| AU (1) | AU729206B2 (enExample) |
| CA (1) | CA2262588A1 (enExample) |
| DE (1) | DE69725596T2 (enExample) |
| ES (1) | ES2213220T3 (enExample) |
| IL (1) | IL128115A (enExample) |
| WO (1) | WO1998004321A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071303A (en) * | 1996-12-08 | 2000-06-06 | Hearten Medical, Inc. | Device for the treatment of infarcted tissue and method of treating infarcted tissue |
| IL124722A0 (en) | 1998-06-02 | 1999-01-26 | Oron Amir | Ischemia laser treatment |
| US8282955B2 (en) | 2001-10-15 | 2012-10-09 | Ferring B.V. | Method for the preparation of a pharmaceutical composition comprising 5-aminosalicylic acid for use in treatment of ulcerative colitis and Crohn's disease |
| US7303578B2 (en) | 2001-11-01 | 2007-12-04 | Photothera, Inc. | Device and method for providing phototherapy to the brain |
| US9993659B2 (en) | 2001-11-01 | 2018-06-12 | Pthera, Llc | Low level light therapy for enhancement of neurologic function by altering axonal transport rate |
| US7534255B1 (en) | 2003-01-24 | 2009-05-19 | Photothera, Inc | Low level light therapy for enhancement of neurologic function |
| US10683494B2 (en) | 2001-11-01 | 2020-06-16 | Pthera LLC | Enhanced stem cell therapy and stem cell production through the administration of low level light energy |
| US10695577B2 (en) | 2001-12-21 | 2020-06-30 | Photothera, Inc. | Device and method for providing phototherapy to the heart |
| US7316922B2 (en) | 2002-01-09 | 2008-01-08 | Photothera Inc. | Method for preserving organs for transplant |
| US7344555B2 (en) | 2003-04-07 | 2008-03-18 | The United States Of America As Represented By The Department Of Health And Human Services | Light promotes regeneration and functional recovery after spinal cord injury |
| US20070042143A1 (en) | 2003-04-23 | 2007-02-22 | Ferring B.V. | Sachet for a pharmaceutical composition |
| US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
| EP1864330B1 (en) * | 2005-03-31 | 2016-10-19 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Light as a replacement for mitrogenic factors on progenitor cells |
| US10357662B2 (en) | 2009-02-19 | 2019-07-23 | Pthera LLC | Apparatus and method for irradiating a surface with light |
| US20090254154A1 (en) | 2008-03-18 | 2009-10-08 | Luis De Taboada | Method and apparatus for irradiating a surface with pulsed light |
| US7575589B2 (en) | 2006-01-30 | 2009-08-18 | Photothera, Inc. | Light-emitting device and method for providing phototherapy to the brain |
| WO2008067455A2 (en) * | 2006-11-30 | 2008-06-05 | Stryker Corporation | System and method for targeted activation of a pharmaceutical agent within the body cavity that is activated by the application of energy |
| WO2008105691A1 (en) * | 2007-02-28 | 2008-09-04 | St. Jude Medical Ab | Device and method for detecting a myocardial infarction and treating the myocardial infarction using therapeutic light |
| US7848035B2 (en) | 2008-09-18 | 2010-12-07 | Photothera, Inc. | Single-use lens assembly |
| EP2424618B1 (en) * | 2009-05-01 | 2022-11-09 | Wayne State University | Light therapy device |
| EP3413826B1 (en) * | 2016-02-12 | 2020-04-08 | Sciton, Inc. | Devices for image-guided light treatment of skin |
| EP3626197A4 (en) * | 2017-05-15 | 2021-02-24 | Hamamatsu Photonics K.K. | OPTICAL MEASURING DEVICE, CATHETER SET AND OPTICAL MEASURING METHOD |
| WO2018212159A1 (ja) * | 2017-05-15 | 2018-11-22 | 浜松ホトニクス株式会社 | カテーテルキット |
| TWI782017B (zh) * | 2017-05-15 | 2022-11-01 | 日商濱松赫德尼古斯股份有限公司 | 導管套組 |
| WO2019198061A1 (en) | 2018-04-13 | 2019-10-17 | Universidade Do Minho | Guidance system, method and devices thereof |
| CN110523004A (zh) * | 2019-08-28 | 2019-12-03 | 师改英 | 一种普通内科专用热疗仪 |
| KR102378498B1 (ko) * | 2021-05-26 | 2022-03-29 | 주식회사 칼라세븐 | 피부 접착식 광선조사기의 사용 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4709703A (en) * | 1985-11-12 | 1987-12-01 | Mayo Foundation | Imaging system and method using radiopaque microspheres for evaluation of organ tissue perfusion |
| US4966597A (en) * | 1988-11-04 | 1990-10-30 | Cosman Eric R | Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection |
| WO1993015676A1 (en) * | 1992-02-05 | 1993-08-19 | Angelase, Inc. | Laser catheter with movable integral fixation wire |
| AU712539B2 (en) * | 1996-01-08 | 1999-11-11 | Biosense, Inc. | Methods and apparatus for myocardial revascularization |
-
1997
- 1997-07-28 JP JP50866498A patent/JP2002511774A/ja not_active Ceased
- 1997-07-28 AU AU36328/97A patent/AU729206B2/en not_active Ceased
- 1997-07-28 WO PCT/IL1997/000257 patent/WO1998004321A1/en not_active Ceased
- 1997-07-28 DE DE69725596T patent/DE69725596T2/de not_active Expired - Fee Related
- 1997-07-28 IL IL12811597A patent/IL128115A/xx not_active IP Right Cessation
- 1997-07-28 ES ES97932974T patent/ES2213220T3/es not_active Expired - Lifetime
- 1997-07-28 CA CA002262588A patent/CA2262588A1/en not_active Abandoned
- 1997-07-28 EP EP97932974A patent/EP0930917B1/en not_active Expired - Lifetime
-
2008
- 2008-08-11 JP JP2008206790A patent/JP2009045454A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009045454A (ja) | 2009-03-05 |
| ES2213220T3 (es) | 2004-08-16 |
| AU3632897A (en) | 1998-02-20 |
| EP0930917A1 (en) | 1999-07-28 |
| EP0930917B1 (en) | 2003-10-15 |
| IL128115A (en) | 2005-06-19 |
| AU729206B2 (en) | 2001-01-25 |
| EP0930917A4 (en) | 2000-03-22 |
| DE69725596D1 (de) | 2003-11-20 |
| DE69725596T2 (de) | 2004-08-05 |
| JP2002511774A (ja) | 2002-04-16 |
| WO1998004321A1 (en) | 1998-02-05 |
| IL128115A0 (en) | 1999-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6443974B1 (en) | Electromagnetic cardiac biostimulation | |
| EP0930917B1 (en) | Electromagnetic cardiac biostimulation | |
| US6736808B1 (en) | Apparatus for emitting therapeutic energy within tissue | |
| AU685559B2 (en) | Atrial mapping and ablation catheter system | |
| US7041095B2 (en) | Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization | |
| US9724537B2 (en) | Abnormal electrical conduction blocking apparatus using photodynamic therapy (PDT) | |
| US5873366A (en) | Method for transmyocardial revascularization | |
| US20020095197A1 (en) | Application of photochemotherapy for the treatment of cardiac arrhythmias | |
| EP2540247A1 (en) | Catheter performing photodynamic ablation of cardiac muscle tissue by photochemical reaction | |
| US20020077687A1 (en) | Catheter assembly for treating ischemic tissue | |
| JP2001509038A (ja) | 経皮心筋血行再建法 | |
| DE69930756D1 (de) | Tmr vorrichtung | |
| Swarup et al. | Ablation of epicardial macroreentrant ventricular tachycardia associated with idiopathic nonischemic dilated cardiomyopathy by a percutaneous transthoracic approach | |
| US20100241058A1 (en) | Oct guided tissue ablation | |
| Maguire et al. | Cardiac radiosurgery (CyberHeart™) for treatment of arrhythmia: physiologic and histopathologic correlation in the porcine model | |
| Curtis et al. | Transvascular argon laser ablation of atrioventricular conduction in dogs: Feasibility and morphological results | |
| IL118968A (en) | Apparatus for biostimulation of myocardial tissue by electromagnetic wave radiation | |
| Bonin et al. | Laser myoplasty for hypertrophic cardiomyopathy: In vitro experience in human postmortem hearts and in vivo experience in a canine model (transarteriai) and human patient (intraoperative) | |
| Blackshear et al. | Interventional dysrhythmia management and the role of laser | |
| DONALDSON et al. | Laser Myoplasty for Hypertrophic Cardiomyopathy | |
| Frazier et al. | Preliminary results of intraoperative excimer laser angioplasty: Phase 1: An adjunct to coronary artery bypass surgery | |
| Pfeiffer | Laser-Induced Channels Promote Direct Myocardial Revascularization | |
| Nilsson | Laser Medicine: Increasing Quality and Lowering Costs | |
| Curtis et al. | Laser catheter ablation of arrhythmias | |
| Scenario Commission on Future Health Care Technology et al. | Lasers in Health Care |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |