CA2262056A1 - Composition, methods and reagents for the synthesis of a soluble form of human pex - Google Patents
Composition, methods and reagents for the synthesis of a soluble form of human pex Download PDFInfo
- Publication number
- CA2262056A1 CA2262056A1 CA002262056A CA2262056A CA2262056A1 CA 2262056 A1 CA2262056 A1 CA 2262056A1 CA 002262056 A CA002262056 A CA 002262056A CA 2262056 A CA2262056 A CA 2262056A CA 2262056 A1 CA2262056 A1 CA 2262056A1
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- CA
- Canada
- Prior art keywords
- pex
- enzyme
- antibody
- mutant
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24011—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral endopeptidase 24.11
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Priority Applications (8)
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| CA002262056A CA2262056A1 (en) | 1999-02-24 | 1999-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human pex |
| EP00906114A EP1159412A2 (en) | 1999-02-24 | 2000-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human phex |
| PCT/CA2000/000201 WO2000050580A2 (en) | 1999-02-24 | 2000-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human phex |
| CA002365094A CA2365094A1 (en) | 1999-02-24 | 2000-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human phex |
| US09/913,955 US6790649B1 (en) | 1999-02-24 | 2000-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX |
| JP2000601144A JP2002541776A (ja) | 1999-02-24 | 2000-02-24 | ヒトｐｈｅｘの可溶性形態の組成物、方法及び合成試薬 |
| AU27900/00A AU776042B2 (en) | 1999-02-24 | 2000-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX |
| US10/862,459 US7427498B2 (en) | 1999-02-24 | 2004-06-08 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX |
Applications Claiming Priority (1)
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|---|---|---|---|
| CA002262056A CA2262056A1 (en) | 1999-02-24 | 1999-02-24 | Composition, methods and reagents for the synthesis of a soluble form of human pex |
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| CA2262056A1 true CA2262056A1 (en) | 2000-08-24 |
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| US (2) | US6790649B1 (enExample) |
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| AU (1) | AU776042B2 (enExample) |
| CA (1) | CA2262056A1 (enExample) |
| WO (1) | WO2000050580A2 (enExample) |
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| WO2002092128A1 (en) * | 2001-05-11 | 2002-11-21 | Genzyme Corporation | Compositions and methods to regulate serum phosphate |
| US7105539B2 (en) | 2002-12-03 | 2006-09-12 | Enobia Pharma | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex |
| WO2004085465A1 (en) * | 2003-03-26 | 2004-10-07 | Enobia Pharma Inc. | Phex substrates and methods using same |
| HUE055861T2 (hu) | 2004-04-21 | 2021-12-28 | Alexion Pharma Inc | Csontbejuttató konjugátumok és azok alkalmazási módszere fehérjék csonthoz kötéséhez |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| AU2011245005A1 (en) | 2010-04-30 | 2012-11-22 | Alexion Pharma Holding | Methods, compositions, and kits for the treatment of matrix mineralization disorders |
| CA2823066A1 (en) | 2010-12-27 | 2012-07-05 | Alexion Pharma International Sarl | Compositions comprising natriuretic peptides and methods of use thereof |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| US10822596B2 (en) | 2014-07-11 | 2020-11-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for treating craniosynostosis |
| CA2967851C (en) | 2014-12-05 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Treating seizure with recombinant alkaline phosphatase |
| US10603361B2 (en) | 2015-01-28 | 2020-03-31 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| RU2745528C2 (ru) | 2015-08-17 | 2021-03-26 | Алексион Фармасьютикалз, Инк. | Производство щелочных фосфатаз |
| WO2017058822A1 (en) | 2015-09-28 | 2017-04-06 | Alexion Pharmaceuticals, Inc. | Identifying effective dosage regimens for tissue non-specific alkaline phosphatase (tnsalp)-enzyme replacement therapy of hypophosphatasia |
| WO2017074466A1 (en) | 2015-10-30 | 2017-05-04 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
| EP3426286A4 (en) | 2016-03-08 | 2019-12-04 | Alexion Pharmaceuticals, Inc. | PROCESS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN |
| EP3436020A4 (en) | 2016-04-01 | 2019-12-25 | Alexion Pharmaceuticals, Inc. | METHOD FOR TREATING HYPOPHOSPHATASIE IN TEENS AND ADULTS |
| JP7613826B2 (ja) | 2016-04-01 | 2025-01-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼによって筋力低下を治療すること |
| US10988744B2 (en) | 2016-06-06 | 2021-04-27 | Alexion Pharmaceuticals, Inc. | Method of producing alkaline phosphatase |
| EP3500289B1 (en) | 2016-08-18 | 2024-10-09 | Alexion Pharmaceuticals, Inc. | Asfotase alfa for use in treating tracheobronchomalacia |
| CA3057502A1 (en) | 2017-03-31 | 2018-10-04 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia (hpp) in adults and adolescents |
| JP2021519590A (ja) | 2018-03-30 | 2021-08-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 糖タンパク質の製造 |
| JP2021534111A (ja) | 2018-08-10 | 2021-12-09 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法 |
| US12433938B2 (en) | 2019-12-09 | 2025-10-07 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| CN115335696B (zh) * | 2020-03-27 | 2024-04-30 | 积水医疗株式会社 | 液相色谱用构件 |
| AU2022218782A1 (en) | 2021-02-12 | 2023-08-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
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|---|---|---|---|---|
| US5840509A (en) * | 1996-07-22 | 1998-11-24 | Eli Lilly And Company | Protease and related nucleic acid compounds |
| CA2264955A1 (en) | 1996-09-05 | 1998-03-12 | Andrew C. Karaplis | Cloning of full-length human pex cdna |
-
1999
- 1999-02-24 CA CA002262056A patent/CA2262056A1/en not_active Abandoned
-
2000
- 2000-02-24 US US09/913,955 patent/US6790649B1/en not_active Expired - Lifetime
- 2000-02-24 AU AU27900/00A patent/AU776042B2/en not_active Ceased
- 2000-02-24 WO PCT/CA2000/000201 patent/WO2000050580A2/en not_active Ceased
- 2000-02-24 JP JP2000601144A patent/JP2002541776A/ja active Pending
- 2000-02-24 EP EP00906114A patent/EP1159412A2/en not_active Withdrawn
-
2004
- 2004-06-08 US US10/862,459 patent/US7427498B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2790000A (en) | 2000-09-14 |
| WO2000050580A2 (en) | 2000-08-31 |
| EP1159412A2 (en) | 2001-12-05 |
| US6790649B1 (en) | 2004-09-14 |
| JP2002541776A (ja) | 2002-12-10 |
| AU776042B2 (en) | 2004-08-26 |
| WO2000050580B1 (en) | 2001-09-07 |
| WO2000050580A3 (en) | 2001-08-02 |
| US7427498B2 (en) | 2008-09-23 |
| US20040234518A1 (en) | 2004-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |