CA2261887C - Conjugues lipidiques polaires covalents associes a des composes biologiquement actifs utilisables dans les onguents - Google Patents

Conjugues lipidiques polaires covalents associes a des composes biologiquement actifs utilisables dans les onguents Download PDF

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Publication number
CA2261887C
CA2261887C CA002261887A CA2261887A CA2261887C CA 2261887 C CA2261887 C CA 2261887C CA 002261887 A CA002261887 A CA 002261887A CA 2261887 A CA2261887 A CA 2261887A CA 2261887 C CA2261887 C CA 2261887C
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CA
Canada
Prior art keywords
drug
skin
spacer
medicinal ointment
polar lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002261887A
Other languages
English (en)
Other versions
CA2261887A1 (fr
Inventor
Milton B. Yatvin
Michael H. B. Stowell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health Science University
Original Assignee
Oregon Health Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health Science University filed Critical Oregon Health Science University
Publication of CA2261887A1 publication Critical patent/CA2261887A1/fr
Application granted granted Critical
Publication of CA2261887C publication Critical patent/CA2261887C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Abstract

Cette invention se rapporte à un procédé visant à faciliter l'entrée de médicaments à l'intérieur de cellules et de tissus à des niveaux pharmacinétiquement utiles, ainsi qu'à un procédé d'apport ciblé de médicaments à des organites spécifiques de la cellule. Cette invention relative au ciblage de conjugués polaires lipidiques et de médicaments constitue un progrès par rapport aux autres procédés de ciblage de médicaments du fait que, conformément à ce procédé, les concentrations intracellulaires de médicaments peuvent atteindre des niveaux qui sont de très loin supérieurs à ceux obtenus par d'autres procédés. L'invention affine également le processus d'apport de médicaments en permettant de diriger des agents thérapeutiques vers certaines structures intracellulaires. Ce procédé convient aux médicaments antiprolifératifs, antibiotiques, antifongiques, antiviraux et antinéoplasiques, notamment lorsque ces médicaments sont utilisés en association à une multiplicité d'autres émollients et agents, et il peut servir à la fabrication de substances à activité topique telles que des onguents, destinées à permettre une introduction rapide et efficace de ces agents dans l'épiderme pour le traitement des dermatoses et autres troubles de la peau.
CA002261887A 1996-07-23 1996-07-23 Conjugues lipidiques polaires covalents associes a des composes biologiquement actifs utilisables dans les onguents Expired - Fee Related CA2261887C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1996/012124 WO1998003204A1 (fr) 1996-07-23 1996-07-23 Conjugues lipidiques polaires covalents associes a des composes biologiquement actifs utilisables dans les onguents

Publications (2)

Publication Number Publication Date
CA2261887A1 CA2261887A1 (fr) 1998-01-29
CA2261887C true CA2261887C (fr) 2007-10-02

Family

ID=22255500

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002261887A Expired - Fee Related CA2261887C (fr) 1996-07-23 1996-07-23 Conjugues lipidiques polaires covalents associes a des composes biologiquement actifs utilisables dans les onguents

Country Status (5)

Country Link
EP (1) EP0917473A1 (fr)
JP (1) JPH11514009A (fr)
AU (1) AU724421B2 (fr)
CA (1) CA2261887C (fr)
WO (1) WO1998003204A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000033883A1 (fr) * 1998-12-04 2000-06-15 Oregon Health Sciences University Conjugues lipides polaires covalents avec medicaments antimicrobiens et antineoplasiques destines a cibler des sites biologiques proteges
US6464992B2 (en) * 2000-04-14 2002-10-15 University Of Kentucky Research Foundation Topical micronutrient delivery system and uses thereof
US7045543B2 (en) 2001-11-05 2006-05-16 Enzrel Inc. Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites
CN103857440B (zh) * 2011-06-22 2018-09-25 维奥姆生物科学有限公司 基于缀合物的抗真菌和抗细菌前药

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
JPH05507929A (ja) * 1990-06-15 1993-11-11 ウェイク　フォレスト　ユニバーシティー エーテル脂質―ヌクレオシド共有結合体
US5256641A (en) * 1990-11-01 1993-10-26 State Of Oregon Covalent polar lipid-peptide conjugates for immunological targeting
US5149794A (en) * 1990-11-01 1992-09-22 State Of Oregon Covalent lipid-drug conjugates for drug targeting
US5543390A (en) * 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting

Also Published As

Publication number Publication date
CA2261887A1 (fr) 1998-01-29
WO1998003204A1 (fr) 1998-01-29
JPH11514009A (ja) 1999-11-30
EP0917473A1 (fr) 1999-05-26
AU724421B2 (en) 2000-09-21
AU6594596A (en) 1998-02-10

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