CA2261793A1 - Phosphatase inhibitors and methods of use thereof - Google Patents

Phosphatase inhibitors and methods of use thereof Download PDF

Info

Publication number
CA2261793A1
CA2261793A1 CA002261793A CA2261793A CA2261793A1 CA 2261793 A1 CA2261793 A1 CA 2261793A1 CA 002261793 A CA002261793 A CA 002261793A CA 2261793 A CA2261793 A CA 2261793A CA 2261793 A1 CA2261793 A1 CA 2261793A1
Authority
CA
Canada
Prior art keywords
segment
compound
bivalent
compounds
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002261793A
Other languages
English (en)
French (fr)
Inventor
Robert L. Rice
April Cunningham
Peter Wipf
John S. Lazo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2261793A1 publication Critical patent/CA2261793A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002261793A 1996-07-30 1997-07-30 Phosphatase inhibitors and methods of use thereof Abandoned CA2261793A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/688,530 US5700821A (en) 1996-07-30 1996-07-30 Phosphatase inhibitors and methods of use thereof
US08/688,530 1996-07-30
PCT/US1997/013408 WO1998004257A1 (en) 1996-07-30 1997-07-30 Phosphatase inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2261793A1 true CA2261793A1 (en) 1998-02-05

Family

ID=24764793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002261793A Abandoned CA2261793A1 (en) 1996-07-30 1997-07-30 Phosphatase inhibitors and methods of use thereof

Country Status (8)

Country Link
US (4) US5700821A (enExample)
EP (1) EP0959884A1 (enExample)
JP (1) JP3268782B2 (enExample)
AR (1) AR008120A1 (enExample)
AU (1) AU715546B2 (enExample)
CA (1) CA2261793A1 (enExample)
IL (1) IL128217A0 (enExample)
WO (1) WO1998004257A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465250B1 (en) 2001-02-09 2002-10-15 Isis Pharmaceuticals, Inc. Antisense modulation of protein phosphatase 2 catalytic subunit alpha expression
US6602713B1 (en) * 2001-02-09 2003-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of protein phosphatase 2 catalytic subunit beta expression
US20040121973A1 (en) * 2002-02-05 2004-06-24 Monia Brett P Antisense modulation of protein phosphatase 2 Catalytic subunit alpha expression
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6989435B2 (en) 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6277566B1 (en) * 1998-02-13 2001-08-21 Phillip A. Beachy Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor
AU3591799A (en) * 1998-04-27 1999-11-16 University Health Network Gene screening methods and related assays
US7051360B1 (en) * 1998-11-30 2006-05-23 United Video Properties, Inc. Interactive television program guide with selectable languages
US7238711B1 (en) * 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
JP2002536346A (ja) * 1999-02-03 2002-10-29 ザ・ジョーンズ・ホプキンス・ユニバーシティ ｐｐ３２の機能の回復により癌を治療する方法
AU6396600A (en) * 1999-08-04 2001-03-05 Chemrx Advanced Technologies, Inc. Solid phase synthesis of oxa- and thiazoles
AU7077400A (en) * 1999-08-31 2001-03-26 Basf Aktiengesellschaft Method of identifying inhibitors of cdc25
AU1073001A (en) * 1999-10-12 2001-04-23 Basf Aktiengesellschaft Method of identifying inhibitors of cdc25
US6620882B1 (en) 2000-05-02 2003-09-16 Advanced Syntech, Llc Solid support template for preparation of highly functionalized heterocycle compounds
US20030027308A1 (en) * 2000-05-30 2003-02-06 Sugen Incorporated Novel human protein phosphatases identified from genomic sequencing
FR2812945B1 (fr) * 2000-08-10 2002-10-04 Aventis Pharma Sa Utilisation de la proteine grf1 et cellules exprimant la proteine grf1 pour le criblage de molecules
US20040157306A1 (en) * 2000-11-13 2004-08-12 Sugen Incorporated Mammalian protein phosphatases
WO2002070680A1 (en) * 2001-03-01 2002-09-12 Basf Aktiengesellschaft Method of identifying inhibitors of cdc25
US20030120073A1 (en) * 2001-04-25 2003-06-26 Seto Christopher T. Alpha-ketocarboxylic acid based inhibitors of phosphoryl tyrosine phosphatases
US20030124590A1 (en) * 2001-10-16 2003-07-03 Kosaku Uyeda Carbohydrate response element binding protein and uses thereof
WO2003042390A1 (en) * 2001-11-13 2003-05-22 Sugen, Inc. Mammalian protein phosphatases
AU2003220222A1 (en) * 2002-03-13 2003-09-29 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
US20050074831A1 (en) * 2002-03-19 2005-04-07 Jasna Jerecic Interaction of NMDA receptor with protein serine threonine phosphatases
US20040023382A1 (en) * 2002-07-31 2004-02-05 Isis Pharmaceuticals Inc. Antisense modulation of PPP3CB expression
US6828149B2 (en) 2002-06-20 2004-12-07 Isis Pharmaceuticals, Inc. Antisense modulation of PPP3R1 expression
WO2004000875A2 (en) * 2002-06-25 2003-12-31 Serono Genetics Institute S.A. Novel kcnq polypeptides, modulators thereof, and their uses in the treatment of mental disorders
MXPA05002197A (es) * 2002-10-02 2005-06-08 Aventis Pharma Gmbh Derivados de hidroxifenilundecano, un procedimiento para su produccion y su uso.
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
CA2601777A1 (en) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
DE102006033321A1 (de) * 2006-07-17 2008-01-24 Westfälische Wilhelms-Universität Münster Medizinische Verwendung von N-Phenylpropenoyl-Aminosäurederivaten und verwandten Verbindungen
KR100980328B1 (ko) * 2007-12-14 2010-09-06 한국생명공학연구원 단백질 포스파타제의 활성을 억제하는트리아졸릴-티오-에타논 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 암 예방 및 치료용조성물
US9486441B2 (en) 2008-04-21 2016-11-08 Signum Biosciences, Inc. Compounds, compositions and methods for making the same
CN119454697B (zh) * 2025-01-07 2025-04-08 首都医科大学附属北京地坛医院 一种小分子化合物在制备抗肝损伤或抗肝纤维化药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696270A (en) * 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
US5280034A (en) * 1991-08-23 1994-01-18 E. R. Squibb & Sons, Inc. Bis-heterocyclic prostaglandin analogs
US5639725A (en) * 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
US5770620A (en) * 1995-06-19 1998-06-23 Ontogen Corporation Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors

Also Published As

Publication number Publication date
EP0959884A1 (en) 1999-12-01
AR008120A1 (es) 1999-12-09
JP3268782B2 (ja) 2002-03-25
WO1998004257A1 (en) 1998-02-05
US5856506A (en) 1999-01-05
JP2000515165A (ja) 2000-11-14
US6040323A (en) 2000-03-21
AU715546B2 (en) 2000-02-03
EP0959884A4 (enExample) 1999-12-15
US5700821A (en) 1997-12-23
IL128217A0 (en) 1999-11-30
AU3820597A (en) 1998-02-20
US5925660A (en) 1999-07-20

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Legal Events

Date Code Title Description
FZDE Discontinued