CA2261020C - Preparation of pichia methanolica auxotrophic mutants - Google Patents

Preparation of pichia methanolica auxotrophic mutants Download PDF

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Publication number
CA2261020C
CA2261020C CA002261020A CA2261020A CA2261020C CA 2261020 C CA2261020 C CA 2261020C CA 002261020 A CA002261020 A CA 002261020A CA 2261020 A CA2261020 A CA 2261020A CA 2261020 C CA2261020 C CA 2261020C
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CA
Canada
Prior art keywords
cells
dna
methanolica
culturing
ade
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002261020A
Other languages
English (en)
French (fr)
Other versions
CA2261020A1 (en
Inventor
Christopher K. Raymond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/703,808 external-priority patent/US5736383A/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of CA2261020A1 publication Critical patent/CA2261020A1/en
Application granted granted Critical
Publication of CA2261020C publication Critical patent/CA2261020C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002261020A 1996-07-17 1997-07-14 Preparation of pichia methanolica auxotrophic mutants Expired - Fee Related CA2261020C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68350096A 1996-07-17 1996-07-17
US60/042,910 1996-07-17
US08/703,808 US5736383A (en) 1996-08-26 1996-08-26 Preparation of Pichia methanolica auxotrophic mutants
US08/703,808 1996-08-26
PCT/US1997/012582 WO1998002536A2 (en) 1996-07-17 1997-07-14 Preparation of pichia methanolica auxotrophic mutants

Publications (2)

Publication Number Publication Date
CA2261020A1 CA2261020A1 (en) 1998-01-22
CA2261020C true CA2261020C (en) 2004-06-08

Family

ID=27103122

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002261020A Expired - Fee Related CA2261020C (en) 1996-07-17 1997-07-14 Preparation of pichia methanolica auxotrophic mutants

Country Status (6)

Country Link
JP (1) JP2002514049A (xx)
CN (1) CN1238806A (xx)
AU (1) AU708572B2 (xx)
CA (1) CA2261020C (xx)
IL (1) IL128072A0 (xx)
WO (1) WO1998002536A2 (xx)

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* Cited by examiner, † Cited by third party
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EP2105446B1 (en) 1998-09-23 2013-08-14 ZymoGenetics, Inc. Cytokine receptor zalpha11
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
WO2000040716A2 (en) 1999-01-07 2000-07-13 Zymogenetics, Inc. Soluble receptor br43x2 and methods of using them for therapy
EP1165791B1 (en) 1999-03-09 2007-10-31 ZymoGenetics, Inc. Human cytokine as ligand of the zalpha receptor and uses thereof
IL147336A0 (en) 1999-07-07 2002-08-14 Zymogenetics Inc Human cytokine receptor
CA2395369C (en) 1999-12-23 2014-07-08 Zymogenetics, Inc. Cytokine zcyto18
CA2412239C (en) 2000-06-26 2013-05-28 Zymogenetics, Inc. Cytokine receptor zcytor17
WO2002066516A2 (en) 2001-02-20 2002-08-29 Zymogenetics, Inc. Antibodies that bind both bcma and taci
KR20040030628A (ko) 2001-05-24 2004-04-09 지모제넥틱스, 인코포레이티드 Ｔａｃｉ-면역글로불린 융합 단백질
CN105131104B (zh) 2001-10-10 2018-11-16 诺和诺德公司 肽的重构和糖缀合
DK1578771T3 (da) 2001-10-10 2013-06-10 Novo Nordisk As Remodellering og glycokonjugering af peptider
US6929932B2 (en) 2001-11-05 2005-08-16 Zymogenetics, Inc. IL-21 antagonists
AU2003280410B8 (en) 2002-01-18 2009-04-23 Zymogenetics, Inc. Cytokine receptor zcytor17 multimers
DK1476541T3 (da) 2002-01-18 2008-11-03 Zymogenetics Inc Cytokin (zcytor17-ligand)
EP1497415B1 (en) 2002-04-19 2010-12-29 ZymoGenetics, L.L.C. Methods for detection or modulation of the interaction of a cytokine receptor with its ligand
EP2338333B1 (en) 2003-04-09 2017-09-06 ratiopharm GmbH Glycopegylation methods and proteins/peptides produced by the methods
EP2166104B1 (en) 2004-08-02 2013-06-12 BASF Plant Science GmbH Method for isolation of transcription termination sequences
CN100347287C (zh) * 2004-09-30 2007-11-07 汪和睦 一种重组多形汉逊酵母菌及其构建方法与应用
AU2006212807A1 (en) 2005-02-08 2006-08-17 Zymogenetics, Inc. Anti-IL-20, anti-IL-22 and anti-IL-22RA antibodies and binding partners and methods of using in inflammation
US20070054360A1 (en) 2005-05-12 2007-03-08 Zeren Gao Compositions and methods for modulating immune responses
EP1922079A2 (en) 2005-08-09 2008-05-21 ZymoGenetics, Inc. Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
JP2009507777A (ja) 2005-08-09 2009-02-26 ザイモジェネティクス，インコーポレイティド ＴＡＣＩ−Ｉｇ融合分子を用いたＢ細胞性腫瘍の処置方法
CA2621623A1 (en) 2005-09-28 2007-04-05 Zymogenetics, Inc. Il-17a and il-17f antagonists and methods of using the same
US8784812B2 (en) 2006-05-15 2014-07-22 Zymogenetics, Inc. Methods for treating autoimmune diseases using a TACI-Ig fusion molecule
US8859230B2 (en) 2007-11-21 2014-10-14 Roskilde Universitet Polypeptides comprising an ice-binding activity
WO2009092806A2 (en) 2008-01-25 2009-07-30 Aarhus Universitet Selective exosite inhibition of papp-a activity against igfbp-4
AU2009327189B2 (en) 2008-12-16 2012-09-06 Novartis Ag Yeast display systems
JP2015509005A (ja) 2012-02-01 2015-03-26 シンセティック ジェノミクス インコーポレーテッド エラーを最少限に抑える核酸分子の合成のための材料及び方法
WO2014202089A2 (en) 2013-06-18 2014-12-24 Roskilde Universitet Variants of anti-freeze polypeptides
CN111157680B (zh) * 2019-12-31 2021-10-26 北京辰安科技股份有限公司 室内挥发性物质的泄漏溯源方法及装置
CN116064597B (zh) * 2023-01-17 2024-04-26 北京大学 通过自主复制rna实现哺乳动物细胞中的定向进化和达尔文适应

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0862640A2 (en) * 1995-11-09 1998-09-09 ZymoGenetics, Inc. Production of gad65 in methylotrophic yeast

Also Published As

Publication number Publication date
CN1238806A (zh) 1999-12-15
AU3885697A (en) 1998-02-09
CA2261020A1 (en) 1998-01-22
IL128072A0 (en) 1999-11-30
AU708572B2 (en) 1999-08-05
WO1998002536A3 (en) 1998-02-26
WO1998002536A2 (en) 1998-01-22
JP2002514049A (ja) 2002-05-14

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