CA2260291C - Antagonists of intestinotrophic glp-2 peptides - Google Patents
Antagonists of intestinotrophic glp-2 peptides Download PDFInfo
- Publication number
- CA2260291C CA2260291C CA2260291A CA2260291A CA2260291C CA 2260291 C CA2260291 C CA 2260291C CA 2260291 A CA2260291 A CA 2260291A CA 2260291 A CA2260291 A CA 2260291A CA 2260291 C CA2260291 C CA 2260291C
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- Prior art keywords
- glp
- peptide
- polypeptide
- analog
- amino acid
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/605—Glucagons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/683,890 US5994500A (en) | 1996-07-19 | 1996-07-19 | Antagonists of intestinotrophic GLP-2 peptides |
| US08/683,890 | 1996-07-19 | ||
| PCT/CA1997/000521 WO1998003547A1 (en) | 1996-07-19 | 1997-07-18 | Antagonists of intestinotrophic glp-2 peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2260291A1 CA2260291A1 (en) | 1998-01-29 |
| CA2260291C true CA2260291C (en) | 2010-09-14 |
Family
ID=24745881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2260291A Expired - Fee Related CA2260291C (en) | 1996-07-19 | 1997-07-18 | Antagonists of intestinotrophic glp-2 peptides |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5994500A (enExample) |
| EP (1) | EP0914341B1 (enExample) |
| JP (1) | JP4026854B2 (enExample) |
| AT (1) | ATE338771T1 (enExample) |
| AU (1) | AU739263B2 (enExample) |
| CA (1) | CA2260291C (enExample) |
| DE (1) | DE69736634T2 (enExample) |
| ES (1) | ES2277676T3 (enExample) |
| WO (1) | WO1998003547A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5834428A (en) * | 1995-04-14 | 1998-11-10 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| US6184201B1 (en) | 1995-04-14 | 2001-02-06 | Nps Allelix Corp. | Intestinotrophic glucagon-like peptide-2 analogs |
| BRPI9708566B8 (pt) | 1996-04-12 | 2022-01-18 | Ontario Inc 1149336 | análogo de glp-2 de mamífero, e, composição farmacêutica. |
| US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
| CA2236519C (en) * | 1997-05-02 | 2011-09-13 | 1149336 Ontario Inc. | Methods of enhancing functioning of the large intestine |
| SE9802080D0 (sv) * | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| AU762012B2 (en) | 1998-12-07 | 2003-06-19 | Ipsen Pharma S.A.S. | Analogues of GLP-1 |
| GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
| US7371721B2 (en) * | 2000-09-18 | 2008-05-13 | Sanos Bioscience A/S | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes |
| US20070135345A1 (en) * | 2000-09-18 | 2007-06-14 | Henriksen Dennis B | Use of GLP-2 for the treatment or prevention, of bone-related disorders |
| EP1970072A1 (en) | 2000-09-18 | 2008-09-17 | Sanos Bioscience A/S | Use of GLP-2 peptides for the treatment of hyperparathyroidism |
| US20080249016A1 (en) * | 2000-09-18 | 2008-10-09 | Sanos Bioscience A/S | Use of GLP-2 in a combination treatment for bone-related disorders |
| DE60226702D1 (de) * | 2001-02-16 | 2008-07-03 | Conjuchem Biotechnologies Inc | Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen |
| US7411039B2 (en) * | 2002-10-14 | 2008-08-12 | Novo Nordisk A/S | GLP-2 compounds, formulations, and uses thereof |
| DE602004031927D1 (de) | 2003-02-04 | 2011-05-05 | Novo Nordisk As | Injektionsvorrichtung mit drehbarer dosiseinstellungsvorrichtung |
| JP2007525425A (ja) * | 2003-03-24 | 2007-09-06 | ノボ ノルディスク アクティーゼルスカブ | Ｇｌｐ−２誘導体 |
| US7259234B2 (en) * | 2003-05-15 | 2007-08-21 | Trustees Of Tufts College | Stable analogs of peptide and polypeptide therapeutics |
| JP2007536214A (ja) | 2003-12-16 | 2007-12-13 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | Ｇｌｐ−１類似体 |
| RU2385879C2 (ru) | 2004-01-21 | 2010-04-10 | Ново Нордиск Хелс Кеа Аг | Способ конъюгации пептидов, опосредованной трансглутаминазой |
| EP1809318B1 (en) | 2004-11-01 | 2013-06-12 | NPS Pharmaceuticals, Inc. | Treatment of short bowel syndrome patients with colon-in-continuity |
| EA014184B1 (ru) * | 2005-05-04 | 2010-10-29 | Зеаланд Фарма А/С | Аналоги глюкагонподобного пептида-2 (glp-2) |
| US7498141B2 (en) | 2005-12-01 | 2009-03-03 | Nps Pharmaceuticals, Inc. | Assay system for GLP-2 receptor ligands |
| US8642727B2 (en) * | 2006-11-08 | 2014-02-04 | Zealand Pharma A/S | Selective glucagon-like-peptide-2 (GLP-2) analogues |
| EP2314616A1 (en) | 2009-10-23 | 2011-04-27 | Ferring B.V. | Peptidic GLP-2 agonists |
| BR112013008957A2 (pt) | 2010-10-15 | 2019-09-24 | Univ Cornell | composições e métodos para tratamento de doenças endócrinas, gastrointestinais ou autoimunes |
| CN102924589B (zh) * | 2011-08-11 | 2016-08-24 | 中肽生化有限公司 | 胰高血糖素样肽-2(glp-2)的类似物及其制备方法和用途 |
| BR112014005744B1 (pt) | 2011-09-12 | 2020-11-17 | Amunix Operating Inc. | proteína de fusão recombinante, composição farmacêutica compreendendo a referida proteína e uso da mesma referência cruzada com pedido relacionado |
| WO2013130683A2 (en) | 2012-02-27 | 2013-09-06 | Amunix Operating Inc. | Xten conjugate compositions and methods of making same |
| TR201802689T4 (tr) | 2012-05-03 | 2018-03-21 | Zealand Pharma As | Glukagon benzeri peptit-2 (glp-2) analogları. |
| ES2979184T3 (es) | 2016-12-09 | 2024-09-24 | Zealand Pharma As | Agonistas duales de glp-1/glp-2 acilados |
| KR102754148B1 (ko) | 2017-06-16 | 2025-01-15 | 질랜드 파마 에이/에스 | 글루카곤-유사-펩티드-2 (glp-2) 유사체의 투여를 위한 용량요법 |
| WO2020020904A1 (en) | 2018-07-23 | 2020-01-30 | Zealand Pharma A/S | Therapeutic uses of glp-2 agonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2961045B2 (ja) * | 1993-02-24 | 1999-10-12 | 日清製粉株式会社 | 腸管粘膜増強促進剤 |
| US5990077A (en) * | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| US5912229A (en) * | 1996-03-01 | 1999-06-15 | Novo Nordisk Als | Use of a pharmaceutical composition comprising an appetite-suppressing peptide |
-
1996
- 1996-07-19 US US08/683,890 patent/US5994500A/en not_active Expired - Fee Related
-
1997
- 1997-07-18 EP EP97932672A patent/EP0914341B1/en not_active Expired - Lifetime
- 1997-07-18 AU AU36157/97A patent/AU739263B2/en not_active Ceased
- 1997-07-18 WO PCT/CA1997/000521 patent/WO1998003547A1/en not_active Ceased
- 1997-07-18 JP JP50640998A patent/JP4026854B2/ja not_active Expired - Fee Related
- 1997-07-18 CA CA2260291A patent/CA2260291C/en not_active Expired - Fee Related
- 1997-07-18 ES ES97932672T patent/ES2277676T3/es not_active Expired - Lifetime
- 1997-07-18 DE DE69736634T patent/DE69736634T2/de not_active Expired - Lifetime
- 1997-07-18 AT AT97932672T patent/ATE338771T1/de not_active IP Right Cessation
-
1999
- 1999-01-19 US US09/233,934 patent/US6489295B1/en not_active Expired - Fee Related
-
2002
- 2002-11-18 US US10/295,820 patent/US20030109449A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU739263B2 (en) | 2001-10-11 |
| EP0914341B1 (en) | 2006-09-06 |
| US20030109449A1 (en) | 2003-06-12 |
| WO1998003547A1 (en) | 1998-01-29 |
| US5994500A (en) | 1999-11-30 |
| ES2277676T3 (es) | 2007-07-16 |
| CA2260291A1 (en) | 1998-01-29 |
| EP0914341A1 (en) | 1999-05-12 |
| US6489295B1 (en) | 2002-12-03 |
| JP4026854B2 (ja) | 2007-12-26 |
| DE69736634D1 (de) | 2006-10-19 |
| JP2000516579A (ja) | 2000-12-12 |
| DE69736634T2 (de) | 2007-10-11 |
| AU3615797A (en) | 1998-02-10 |
| ATE338771T1 (de) | 2006-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20120718 |