CA2255579A1 - Proteine kinase p38-2 activee par mitogene et modes d'utilisation dudit produit - Google Patents

Proteine kinase p38-2 activee par mitogene et modes d'utilisation dudit produit Download PDF

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Publication number
CA2255579A1
CA2255579A1 CA002255579A CA2255579A CA2255579A1 CA 2255579 A1 CA2255579 A1 CA 2255579A1 CA 002255579 A CA002255579 A CA 002255579A CA 2255579 A CA2255579 A CA 2255579A CA 2255579 A1 CA2255579 A1 CA 2255579A1
Authority
CA
Canada
Prior art keywords
polypeptide
agent
kinase
substrate
cascade
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002255579A
Other languages
English (en)
Inventor
Bernd Stein
Maria X.H. Yang
David B. Young
Miguel S. Barbosa
Francesco Belardetti
M. A. Wilk-Blaszczak
Melanie Cobb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UT Southwestern Medical Center
Signal Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/651,940 external-priority patent/US5948885A/en
Application filed by Individual filed Critical Individual
Publication of CA2255579A1 publication Critical patent/CA2255579A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des compositions et des procédés permettant de traiter des maladies associées aux cascades de protéine kinase activée par mitogène. L'invention décrit en particulier la protéine kinase p38-2 activée par mitogène et des variantes polypeptides de ladite protéine qui stimulent la phosphorylation et l'activation de substrats tels que l'ATF2. Les polypeptides peuvent être utilisés, par exemple, pour identifier des anticorps ou d'autres agents qui inhibent la transduction de signal via la cascade de la kinase p38-2. Les polypeptides et les agents peuvent être utilisés dans une variété de procédés comme, par exemple, pour réduire la sensibilité à la douleur.
CA002255579A 1996-05-20 1997-05-20 Proteine kinase p38-2 activee par mitogene et modes d'utilisation dudit produit Abandoned CA2255579A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/651,940 1996-05-20
US08/651,940 US5948885A (en) 1996-05-20 1996-05-20 Mitogen-activated protein kinase p38-2 and methods of use therefor
US84008297A 1997-04-09 1997-04-09
US08/840,082 1997-04-09
PCT/US1997/008738 WO1997044467A1 (fr) 1996-05-20 1997-05-20 PROTEINE KINASE p38-2 ACTIVEE PAR MITOGENE ET MODES D'UTILISATION DUDIT PRODUIT

Publications (1)

Publication Number Publication Date
CA2255579A1 true CA2255579A1 (fr) 1997-11-27

Family

ID=27096185

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002255579A Abandoned CA2255579A1 (fr) 1996-05-20 1997-05-20 Proteine kinase p38-2 activee par mitogene et modes d'utilisation dudit produit

Country Status (5)

Country Link
EP (1) EP0914450A1 (fr)
JP (1) JP2002515744A (fr)
AU (1) AU736316B2 (fr)
CA (1) CA2255579A1 (fr)
WO (1) WO1997044467A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6608060B1 (en) 1996-12-18 2003-08-19 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6376214B1 (en) * 1997-02-18 2002-04-23 Smithkline Beecham Corporation DNA encoding a novel homolog of CSBP/p38 MAP kinase
AU4273099A (en) 1998-06-24 2000-01-10 Medical Research Council Polypeptides, polynucleotides and uses thereof
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
CA2360934A1 (fr) 1999-02-22 2000-08-31 Lin-Hua Zhang Derives polycyclo heterocycliques utilises en tant qu'agents anti-inflammatoires
DE60023853T2 (de) 1999-03-12 2006-05-24 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
CN1511830A (zh) 1999-03-12 2004-07-14 ���ָ��.Ӣ��ķҩ�﹫˾ 作为消炎剂的化合物
CA2374737C (fr) 1999-07-09 2008-02-12 Boehringer Ingelheim Pharmaceuticals, Inc. Nouveau procede de synthese de composes d'uree a substitution heteroaryle
US6525046B1 (en) 2000-01-18 2003-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as antiinflammatory agents
US6608052B2 (en) 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
DE60227524D1 (de) 2001-07-16 2008-08-21 Fuyuki Ishikawa Neues verfahren zur induktion von zellulären seneszenz und screening-verfahren für ein mittel gegen alterung
ES2299689T3 (es) 2002-02-25 2008-06-01 Boehringer Ingelheim Pharmaceuticals Inc. Compuestos de cicloalquil-uera fusionada con benzo 1,4-disustituido, utiles para el tratamiento de enfermedades por citoquinas.
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
FR2869416B1 (fr) * 2004-04-27 2007-01-12 Centre Nat Rech Scient Cnrse Procede d'identification d'un ligand capable de moduler selectivement une cascade fonctionnelle impliquant une cible et ses applications pour le criblage a haut-debit de molecules d'interet.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736381A (en) * 1995-05-19 1998-04-07 Davis; Roger J. Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases

Also Published As

Publication number Publication date
JP2002515744A (ja) 2002-05-28
EP0914450A1 (fr) 1999-05-12
AU3139797A (en) 1997-12-09
AU736316B2 (en) 2001-07-26
WO1997044467A1 (fr) 1997-11-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDC Discontinued application reinstated
FZDE Discontinued