CA2253832A1 - Isoformes de recepteur du gene ob et acides nucleiques les codant - Google Patents

Isoformes de recepteur du gene ob et acides nucleiques les codant Download PDF

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Publication number
CA2253832A1
CA2253832A1 CA002253832A CA2253832A CA2253832A1 CA 2253832 A1 CA2253832 A1 CA 2253832A1 CA 002253832 A CA002253832 A CA 002253832A CA 2253832 A CA2253832 A CA 2253832A CA 2253832 A1 CA2253832 A1 CA 2253832A1
Authority
CA
Canada
Prior art keywords
isoform
rat
isoforms
receptor
mouse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002253832A
Other languages
English (en)
Inventor
C. Thomas Caskey
John W. Hess
Patricia Hey
Michael S. Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9610995.4A external-priority patent/GB9610995D0/en
Application filed by Individual filed Critical Individual
Publication of CA2253832A1 publication Critical patent/CA2253832A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Le récepteur du gène ob présente de nombreuses isoformes résultant d'un épissage différent, ces nouvelles isoformes, appelées c', f et g, sont décrites. Les acides nucléiques codant ces isoformes sont présentés. De même, une partie de l'invention a trait à des vecteurs contenant l'acide nucléique codant les récepteurs, des cellules hôtes transformées à l'aide de ces gènes ainsi que des dosages utilisant les gènes ou les isoformes protéiques.
CA002253832A 1996-05-06 1997-05-02 Isoformes de recepteur du gene ob et acides nucleiques les codant Abandoned CA2253832A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1689996P 1996-05-06 1996-05-06
US60/016,899 1996-05-06
GBGB9610995.4A GB9610995D0 (en) 1996-05-24 1996-05-24 OB Receptor isoforms and nucleic acids encoding them
GB9610995.4 1996-05-24
PCT/US1997/007521 WO1997042340A1 (fr) 1996-05-06 1997-05-02 Isoformes de recepteur du gene ob et acides nucleiques les codant

Publications (1)

Publication Number Publication Date
CA2253832A1 true CA2253832A1 (fr) 1997-11-13

Family

ID=26309397

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253832A Abandoned CA2253832A1 (fr) 1996-05-06 1997-05-02 Isoformes de recepteur du gene ob et acides nucleiques les codant

Country Status (4)

Country Link
EP (1) EP0900282A4 (fr)
JP (1) JP2000512486A (fr)
CA (1) CA2253832A1 (fr)
WO (1) WO1997042340A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) * 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US7063958B1 (en) 1996-01-16 2006-06-20 The Rockefeller University Nucleic acids db, the receptor for leptin
US7148004B1 (en) 1997-01-16 2006-12-12 The Rockefeller University Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
US7084252B1 (en) 1996-01-16 2006-08-01 The Rockefeller University DB, the receptor for leptin
US7619079B2 (en) 1996-02-14 2009-11-17 The Rockefeller University Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
US6770444B2 (en) 1998-07-16 2004-08-03 Synaptic Pharmaceutical Corporation Methods of identifying or screening for agents that binds the Ob-Re

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228839A1 (de) * 1992-08-29 1994-03-03 Behringwerke Ag Verfahren zum Nachweis und zur Bestimmung von Mediatoren
US5643748A (en) * 1994-09-14 1997-07-01 Progenitor, Inc. HU-B1.219, a novel human hematopoietin receptor
EP0922052A4 (fr) * 1996-02-22 2001-08-01 Merck & Co Inc Recepteurs de l'obesite du rat et nucleotides codant ces recepteurs
WO1997041217A1 (fr) * 1996-04-30 1997-11-06 Otsuka Pharmaceutical Co., Ltd. GENES RECEPTEURS DE LA PROTEINE ob ET UTILISATION DE CES GENES

Also Published As

Publication number Publication date
EP0900282A4 (fr) 2001-04-11
JP2000512486A (ja) 2000-09-26
WO1997042340A1 (fr) 1997-11-13
EP0900282A1 (fr) 1999-03-10

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Legal Events

Date Code Title Description
FZDE Discontinued