CA2251727A1 - Regulation du volume cellulaire par des canaux polypeptidiques de conduction des chlorures - Google Patents

Regulation du volume cellulaire par des canaux polypeptidiques de conduction des chlorures Download PDF

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Publication number
CA2251727A1
CA2251727A1 CA002251727A CA2251727A CA2251727A1 CA 2251727 A1 CA2251727 A1 CA 2251727A1 CA 002251727 A CA002251727 A CA 002251727A CA 2251727 A CA2251727 A CA 2251727A CA 2251727 A1 CA2251727 A1 CA 2251727A1
Authority
CA
Canada
Prior art keywords
cryptdin
polypeptide
icln
channel
therapeutic composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002251727A
Other languages
English (en)
Inventor
Wayne Lencer
James Madara
Michael Selsted
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Brigham and Womens Hospital Inc
Childrens Medical Center Corp
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc, Childrens Medical Center Corp, University of California filed Critical Brigham and Womens Hospital Inc
Publication of CA2251727A1 publication Critical patent/CA2251727A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur des compositions thérapeutiques et sur des méthodes de traitement d'une maladie caractérisée par un défaut de conduction des chlorures à travers la membrane cellulaire. Lesdites compositions contiennent un polypeptide présentant une ou plusieurs des caractéristiques suivantes: (1) capacité de formation spontanée d'un canal dans une double couche de lipide, (2) capacité de transport sélectif d'ions chlorure à travers cette double couche, et (3) capacité de dissolution dans une solution physiologique aqueux. Ces polypeptides comportent non exclusivement des molécules d'I¿Cln? et de porine, telles que l'aérolysine, la cryptdine 2 et la cryptdine 3.
CA002251727A 1996-04-22 1997-04-18 Regulation du volume cellulaire par des canaux polypeptidiques de conduction des chlorures Abandoned CA2251727A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1620996P 1996-04-22 1996-04-22
US60/016,209 1996-04-22
US83968297A 1997-04-14 1997-04-14
US08/839,682 1997-04-14

Publications (1)

Publication Number Publication Date
CA2251727A1 true CA2251727A1 (fr) 1997-10-30

Family

ID=26688313

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002251727A Abandoned CA2251727A1 (fr) 1996-04-22 1997-04-18 Regulation du volume cellulaire par des canaux polypeptidiques de conduction des chlorures

Country Status (4)

Country Link
JP (1) JP2002515872A (fr)
AU (1) AU2923097A (fr)
CA (1) CA2251727A1 (fr)
WO (1) WO1997039766A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009642A2 (fr) * 2000-07-28 2002-02-07 University Of Maryland, Baltimore Enterotoxine accessoire du cholera et ses analogues utilises comme activateurs du canal de chlorures dependant de calcium

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432270A (en) * 1990-10-25 1995-07-11 Zasloff; Michael A. DNA encoding tracheal antimicrobial peptides
WO1993024513A1 (fr) * 1992-05-22 1993-12-09 The Children's Hospital Of Philadelphia DEFENSINES GASTRO-INTESTINALES, SEQUENCES ADNc ET LEUR PROCEDE DE PRODUCTION ET D'UTILISATION
JPH08501070A (ja) * 1992-05-26 1996-02-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗生物クリプトジンペプチド及びその使用方法
US5422424A (en) * 1992-05-26 1995-06-06 The Regents Of The University Of California Antibiotic cryptdin peptides and methods of their use
US5650096A (en) * 1994-12-09 1997-07-22 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules

Also Published As

Publication number Publication date
JP2002515872A (ja) 2002-05-28
AU2923097A (en) 1997-11-12
WO1997039766A1 (fr) 1997-10-30

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