CA2250930C - Derives du 4-[(thien-3-yl)methyl]-imidazole ayant une activite agoniste vis-a-vis de l'adrenorecepteur .alpha.2 - Google Patents

Derives du 4-[(thien-3-yl)methyl]-imidazole ayant une activite agoniste vis-a-vis de l'adrenorecepteur .alpha.2 Download PDF

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Publication number
CA2250930C
CA2250930C CA002250930A CA2250930A CA2250930C CA 2250930 C CA2250930 C CA 2250930C CA 002250930 A CA002250930 A CA 002250930A CA 2250930 A CA2250930 A CA 2250930A CA 2250930 C CA2250930 C CA 2250930C
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Canada
Prior art keywords
solution
methyl
added
combined
vacuo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002250930A
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English (en)
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CA2250930A1 (fr
Inventor
Robert E. Boyd
Chris Royce Rasmussen
Jeffrey B. Press
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Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
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Priority claimed from US08/625,442 external-priority patent/US5750720A/en
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of CA2250930A1 publication Critical patent/CA2250930A1/fr
Application granted granted Critical
Publication of CA2250930C publication Critical patent/CA2250930C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Les 4-[(thien-3-yl)méthyl]-imidazoles de formule (I) où R désigne un hydrogène ou un méthyle et où X désigne un C1-4alkyle, un brome ou un chlore, ou de formule (II) où Y désigne un hydrogène, un C1-4alkyle, un brome ou un chlore et où Z désigne un C1-4alkyle, un brome ou un chlore, ont des propriétés analgésiques exceptionnelles.
CA002250930A 1996-03-28 1997-03-26 Derives du 4-[(thien-3-yl)methyl]-imidazole ayant une activite agoniste vis-a-vis de l'adrenorecepteur .alpha.2 Expired - Fee Related CA2250930C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/625,442 US5750720A (en) 1996-03-28 1996-03-28 4- (thien-3-yl)methyl!-imidazole analgesics
US08/625,442 1996-03-28
PCT/US1997/004773 WO1997035858A1 (fr) 1996-03-28 1997-03-26 DERIVES DU 4-[(THIEN-3-YL)METHYL]-IMIDAZOLE AYANT UNE ACTIVITE AGONISTE VIS-A-VIS DE L'ADRENORECEPTEUR α¿2?

Publications (2)

Publication Number Publication Date
CA2250930A1 CA2250930A1 (fr) 1997-10-02
CA2250930C true CA2250930C (fr) 2005-12-13

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CA002250930A Expired - Fee Related CA2250930C (fr) 1996-03-28 1997-03-26 Derives du 4-[(thien-3-yl)methyl]-imidazole ayant une activite agoniste vis-a-vis de l'adrenorecepteur .alpha.2

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CA (1) CA2250930C (fr)

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CA2250930A1 (fr) 1997-10-02

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