CA2249290A1 - Bibliotheque de ligands a base d'hydrates de carbone, dosage et procede correspondants - Google Patents

Bibliotheque de ligands a base d'hydrates de carbone, dosage et procede correspondants Download PDF

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Publication number
CA2249290A1
CA2249290A1 CA 2249290 CA2249290A CA2249290A1 CA 2249290 A1 CA2249290 A1 CA 2249290A1 CA 2249290 CA2249290 CA 2249290 CA 2249290 A CA2249290 A CA 2249290A CA 2249290 A1 CA2249290 A1 CA 2249290A1
Authority
CA
Canada
Prior art keywords
carbohydrate
glycosyl
distinct
mmol
solid support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2249290
Other languages
English (en)
Inventor
Rui Liang
Lin Yan
Jennifer Loebach
Daniel E. Kahne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2249290A1 publication Critical patent/CA2249290A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention se rapporte à une bibliothèque de ligands à base d'hydrates de carbone, qui comprend une pluralité de ligands distincts contenant du sucre, chacun lié à une partie résoluble d'un support solide. La bibliothèque est construite selon un procédé qui comprend une étape de formation d'une liaison glycosyle. Des bibliothèque de tailles différentes peuvent être constituées selon le procédé décrit dans cette invention, dans lesquelles un grand nombre d'espèces distinctes sont réalisées sensiblement concurremment par formation de liaisons glycosyles entre de nombreux types de participants. En outre, l'invention porte sur un dosage, qui permet le criblage sensiblement simultané de pratiquement tous les membres de la bibliothèque. L'isolement de ligands nouveaux de faible affinité est ainsi facilité.
CA 2249290 1996-03-21 1997-03-21 Bibliotheque de ligands a base d'hydrates de carbone, dosage et procede correspondants Abandoned CA2249290A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1537996P 1996-03-21 1996-03-21
US60/015,379 1996-03-21

Publications (1)

Publication Number Publication Date
CA2249290A1 true CA2249290A1 (fr) 1997-09-25

Family

ID=21771058

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2249290 Abandoned CA2249290A1 (fr) 1996-03-21 1997-03-21 Bibliotheque de ligands a base d'hydrates de carbone, dosage et procede correspondants

Country Status (4)

Country Link
EP (1) EP0901629A4 (fr)
AU (1) AU2341397A (fr)
CA (1) CA2249290A1 (fr)
WO (1) WO1997035202A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000507247A (ja) * 1996-03-21 2000-06-13 プリンストン ユニバーシティー グリコシル化に有用なスルフィニルヘキソース誘導体
WO1998011436A1 (fr) * 1996-09-13 1998-03-19 Whitehead Institute For Biomedical Research Augmentation de l'affinite non specifique pour identifier des membres d'une bibliotheque combinatoire
AU4322799A (en) * 1998-05-28 1999-12-13 Incara Pharmaceuticals Corp. Carbohydrate-based scaffold compounds, combinatorial libraries and methods for their construction
US6335155B1 (en) 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
AU2606700A (en) * 1999-01-12 2000-08-01 Princeton University Saccharides linked to compounds that bind cell-surface peptides or proteins
US20010051349A1 (en) 2000-02-17 2001-12-13 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
ATE478083T1 (de) 1999-03-05 2010-09-15 Massachusetts Inst Technology Linker zur synthese von oligosacchariden auf festträgern
US20020098513A1 (en) * 2000-02-17 2002-07-25 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
US6656694B2 (en) 2001-01-11 2003-12-02 Theravance, Inc. Method for identifying a ligand for a biological substrate
JP2004531700A (ja) * 2001-02-05 2004-10-14 グラフィニティー、ファーマスーティカルス アーゲー 低親和性スクリーニング法
EP1360493A1 (fr) * 2001-02-07 2003-11-12 Graffinity Pharmaceutical Design GmbH Methode de criblage utilisant des supports solides modifies par des monocouches autoassemblees

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
EP0601417A3 (fr) * 1992-12-11 1998-07-01 Hoechst Aktiengesellschaft Physiologiquement compatible et dégradable bloques de récepteur d'hydrate de carbone à base de polymère, procédé de leur préparation et leur utilisation
IL108748A0 (en) * 1993-02-23 1994-08-26 Univ Princeton Solution and solid-phase formation of glycosidic linkages
AU7193494A (en) * 1993-07-21 1995-02-20 Oxford Glycosystems Ltd Saccharides, their synthesis and use
WO1995018971A1 (fr) * 1994-01-11 1995-07-13 Affymax Technologies N.V. Procede de synthese chimique en phase gazeuse de glycoconjugues
US5575324A (en) * 1995-04-07 1996-11-19 Hwang; Charles Sunshield and method of manufacture of sunshield
AU5855296A (en) * 1995-05-19 1996-11-29 Glycomed Incorporated Collection of activated glycoside compounds and their biolog ical use

Also Published As

Publication number Publication date
WO1997035202A1 (fr) 1997-09-25
EP0901629A4 (fr) 2000-02-02
AU2341397A (en) 1997-10-10
EP0901629A1 (fr) 1999-03-17

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