CA2246027A1 - Derives de benzylamidine avec activite de fixation provenant des recepteurs de la serotonine - Google Patents
Derives de benzylamidine avec activite de fixation provenant des recepteurs de la serotonine Download PDFInfo
- Publication number
- CA2246027A1 CA2246027A1 CA 2246027 CA2246027A CA2246027A1 CA 2246027 A1 CA2246027 A1 CA 2246027A1 CA 2246027 CA2246027 CA 2246027 CA 2246027 A CA2246027 A CA 2246027A CA 2246027 A1 CA2246027 A1 CA 2246027A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- butyl
- dihydro
- imidazole
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
- C07D233/10—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2246027 CA2246027A1 (fr) | 1998-08-27 | 1998-08-27 | Derives de benzylamidine avec activite de fixation provenant des recepteurs de la serotonine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2246027 CA2246027A1 (fr) | 1998-08-27 | 1998-08-27 | Derives de benzylamidine avec activite de fixation provenant des recepteurs de la serotonine |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2246027A1 true CA2246027A1 (fr) | 2000-02-27 |
Family
ID=29409805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2246027 Abandoned CA2246027A1 (fr) | 1998-08-27 | 1998-08-27 | Derives de benzylamidine avec activite de fixation provenant des recepteurs de la serotonine |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2246027A1 (fr) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007085557A2 (fr) * | 2006-01-27 | 2007-08-02 | F. Hoffmann-La Roche Ag | Utilisation de 2-imidazole substitue de derives d'imidazoline |
US7652055B2 (en) | 2007-07-02 | 2010-01-26 | Hoffman-La Roche Inc. | 2-imidazolines |
US7812047B2 (en) | 2007-07-03 | 2010-10-12 | Hoffman-La Roche Inc. | 4-imidazolines |
US7834044B2 (en) | 2006-11-02 | 2010-11-16 | Hoffman-Laroche Inc. | Substituted-2-imidazoles |
US7858652B2 (en) | 2006-11-16 | 2010-12-28 | Hoffmann-La Roche Inc. | Substituted 4-imidazoles |
US7858653B2 (en) | 2006-12-13 | 2010-12-28 | Hoffman-La Roche Inc. | 2-imidazoles |
US7902238B2 (en) | 2007-02-15 | 2011-03-08 | Hoffmann-La Roche Inc. | 2-aminooxazolines as TAAR1 ligands |
US8008305B2 (en) | 2007-08-03 | 2011-08-30 | Hoffmann-La Roche Inc. | TAAR1 ligands |
US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US8389507B2 (en) | 2007-07-27 | 2013-03-05 | Hoffmann-La Roche Inc. | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands |
US8399463B2 (en) | 2006-12-18 | 2013-03-19 | Hoffmann-La Roche Inc. | Imidazole derivatives |
US8586617B2 (en) | 2006-10-19 | 2013-11-19 | Hoffmann-La Roche Inc. | Aminomethyl-4-imidazoles |
US8604061B2 (en) | 2007-02-02 | 2013-12-10 | Hoffmann-La Roche Inc. | 2-aminooxazolines as TAAR1 ligands |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US10508107B2 (en) | 2016-03-17 | 2019-12-17 | Hoffmann-La Roche Inc. | Morpholine derivative |
-
1998
- 1998-08-27 CA CA 2246027 patent/CA2246027A1/fr not_active Abandoned
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007085557A3 (fr) * | 2006-01-27 | 2007-09-20 | Hoffmann La Roche | Utilisation de 2-imidazole substitue de derives d'imidazoline |
US7875645B2 (en) | 2006-01-27 | 2011-01-25 | Hoffman-La Roche Inc. | Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives |
WO2007085557A2 (fr) * | 2006-01-27 | 2007-08-02 | F. Hoffmann-La Roche Ag | Utilisation de 2-imidazole substitue de derives d'imidazoline |
US8586617B2 (en) | 2006-10-19 | 2013-11-19 | Hoffmann-La Roche Inc. | Aminomethyl-4-imidazoles |
US7834044B2 (en) | 2006-11-02 | 2010-11-16 | Hoffman-Laroche Inc. | Substituted-2-imidazoles |
US7858652B2 (en) | 2006-11-16 | 2010-12-28 | Hoffmann-La Roche Inc. | Substituted 4-imidazoles |
US7858653B2 (en) | 2006-12-13 | 2010-12-28 | Hoffman-La Roche Inc. | 2-imidazoles |
US8399463B2 (en) | 2006-12-18 | 2013-03-19 | Hoffmann-La Roche Inc. | Imidazole derivatives |
US8604061B2 (en) | 2007-02-02 | 2013-12-10 | Hoffmann-La Roche Inc. | 2-aminooxazolines as TAAR1 ligands |
US7902238B2 (en) | 2007-02-15 | 2011-03-08 | Hoffmann-La Roche Inc. | 2-aminooxazolines as TAAR1 ligands |
US7652055B2 (en) | 2007-07-02 | 2010-01-26 | Hoffman-La Roche Inc. | 2-imidazolines |
US7812047B2 (en) | 2007-07-03 | 2010-10-12 | Hoffman-La Roche Inc. | 4-imidazolines |
US8389507B2 (en) | 2007-07-27 | 2013-03-05 | Hoffmann-La Roche Inc. | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands |
US8008305B2 (en) | 2007-08-03 | 2011-08-30 | Hoffmann-La Roche Inc. | TAAR1 ligands |
US8242153B2 (en) | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
US8729113B2 (en) | 2008-07-24 | 2014-05-20 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2yl derivatives |
US8354441B2 (en) | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
US10508107B2 (en) | 2016-03-17 | 2019-12-17 | Hoffmann-La Roche Inc. | Morpholine derivative |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |