CA2244862A1 - Substituted amide derivatives - Google Patents

Abstract

The present invention relates to a compound represented by general formula (I) or a pharmaceutically acceptable salt or ester thereof:
(see formula I) (wherein each of (see formula II) is an aryl group or an aromatic heterocyclic group; A1 is a C1-6 chain hydrocarbon group or a group represented by -A1a-W1-A1b- (wherein W1 is an oxygen atom, a sulfur atom, an ethynylene group, a cyclopropylene group or a group represented by -NR w-); A2 is a C1-8 chain hydrocarbon group; R1 is a lower alkyl group, a lower alkenyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a group represented by R a COO-(wherein R a is a hydrogen atom, an amino group, a lower alkyl group, a lower alkoxy group or a lower alkylamino group) or by R b CONR c- (wherein R b is a hydrogen atom, an amino group, a lower alkyl group, a lower alkoxy group or a lower alkylamino group) or an alicyclic group; R2 is a lower alkyl group; and each of X and Y is an oxygen atom, a sulfur atom, a carbonyl group, a group represented by -CHR d- or by -NR e-, or X and Y together represent a vinylene group or an ethynylene group, provided that when one of X and Y is an oxygen atom, a sulfur atom or group represented by -NR e-, the other is a carbonyl group or a group represented by -CHR d-] and an antitumor agent comprising it as an active ingredient.