WO1997029077A1 - Substituted amide derivatives - Google Patents

Substituted amide derivatives Download PDF

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Publication number
WO1997029077A1
WO1997029077A1 PCT/JP1997/000302 JP9700302W WO9729077A1 WO 1997029077 A1 WO1997029077 A1 WO 1997029077A1 JP 9700302 W JP9700302 W JP 9700302W WO 9729077 A1 WO9729077 A1 WO 9729077A1
Authority
WO
WIPO (PCT)
Prior art keywords
group represented
hydrocarbyl
single bond
sch2
ch2s
Prior art date
Application number
PCT/JP1997/000302
Other languages
French (fr)
Japanese (ja)
Inventor
Yoshikazu Iwasawa
Tetsuya Aoyama
Kumiko Kawakami
Sachie Arai
Toshihiko Satoh
Yoshiaki Monden
Original Assignee
Banyu Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.
Priority to AU16190/97A priority Critical patent/AU1619097A/en
Publication of WO1997029077A1 publication Critical patent/WO1997029077A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds represented by general formula (I), pharmacologically acceptable salts or esters thereof, and antitumor agents comprising these as the active ingredients: wherein Ar1 represents aryl or heterocyclic aromatic group; Ar represents a group represented by (A) or (B); Ar?2 and Ar3¿ each represents aryl or heteroaryl; A1 represents C¿1-4? hydrocarbyl; A?2¿ represents C¿1-8? hydrocarbyl; m is an integer of 1 to 6; n and p each is an integer of 0 to 3; Q?1¿ represents a single bond, a group represented by -CH¿2?O-, -OCH2-, -CH2S-, or -SCH2-, or C1-6 hydrocarbyl; Q?2¿ represents a single bond or a group represented by -(CH¿2?)m- or -(CH2)n-W-(CH2)p-; Q?3¿ represents a single bond, oxygen, sulfur, methylene, vinylene, or a group represented by -CO-, -NH-, -COO-, -OCO-, -CH¿2?CH2-, -OCH2-, -SCH2-, -CH2O-, -CH2S-, -NHCO-, or -CONH-; R?1¿ represents lower alkyl; and W represents oxygen, sulfur, vinylene, or ethynylene.
PCT/JP1997/000302 1996-02-07 1997-02-07 Substituted amide derivatives WO1997029077A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16190/97A AU1619097A (en) 1996-02-07 1997-02-07 Substituted amide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8/45501 1996-02-07
JP4550196 1996-02-07

Publications (1)

Publication Number Publication Date
WO1997029077A1 true WO1997029077A1 (en) 1997-08-14

Family

ID=12721160

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/000302 WO1997029077A1 (en) 1996-02-07 1997-02-07 Substituted amide derivatives

Country Status (2)

Country Link
AU (1) AU1619097A (en)
WO (1) WO1997029077A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
WO2017047594A1 (en) * 2015-09-14 2017-03-23 国立大学法人岐阜大学 Nucleoside derivative and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138214A (en) * 1993-02-12 1995-05-30 Banyu Pharmaceut Co Ltd Substituted amic acid derivative
WO1996005169A1 (en) * 1994-08-12 1996-02-22 Banyu Pharmaceutical Co., Ltd. N,n-disubstituted amic acid derivative
WO1996005168A1 (en) * 1994-08-11 1996-02-22 Banyu Pharmaceutical Co., Ltd. Substituted amide derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07138214A (en) * 1993-02-12 1995-05-30 Banyu Pharmaceut Co Ltd Substituted amic acid derivative
WO1996005168A1 (en) * 1994-08-11 1996-02-22 Banyu Pharmaceutical Co., Ltd. Substituted amide derivative
WO1996005169A1 (en) * 1994-08-12 1996-02-22 Banyu Pharmaceutical Co., Ltd. N,n-disubstituted amic acid derivative

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
WO2017047594A1 (en) * 2015-09-14 2017-03-23 国立大学法人岐阜大学 Nucleoside derivative and use thereof
JPWO2017047594A1 (en) * 2015-09-14 2018-10-11 国立大学法人岐阜大学 Nucleoside derivatives and uses thereof

Also Published As

Publication number Publication date
AU1619097A (en) 1997-08-28

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