CA2240183A1 - Composes de bases de schiff contenant du cobalt - Google Patents

Composes de bases de schiff contenant du cobalt Download PDF

Info

Publication number
CA2240183A1
CA2240183A1 CA002240183A CA2240183A CA2240183A1 CA 2240183 A1 CA2240183 A1 CA 2240183A1 CA 002240183 A CA002240183 A CA 002240183A CA 2240183 A CA2240183 A CA 2240183A CA 2240183 A1 CA2240183 A1 CA 2240183A1
Authority
CA
Canada
Prior art keywords
alkyl
alcohol
amine
cobalt
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002240183A
Other languages
English (en)
Inventor
Thomas J. Meade
Toshihiko Takeuchi
Harry B. Gray
Melvin Simon
Angelique Y. Louie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/570,761 external-priority patent/US6008190A/en
Application filed by Individual filed Critical Individual
Publication of CA2240183A1 publication Critical patent/CA2240183A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/06—Cobalt compounds
    • C07F15/065—Cobalt compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)

Abstract

L'invention se rapporte à des composés de cobalt dans lesquels le cobalt divalent ou trivalent est complexé avec des bases de Schiff tétradentées solubles dans l'eau. Les bases de Schiff tétradentées contiennent de préférence deux atomes d'azote et deux atomes d'oxygène jouant le rôle d'atomes de coordination. Ces composés peuvent contenir des fractions de ciblage de polypeptides ou d'acide nucléique et peuvent être utilisés pour inhiber des enzymes telles que la thrombine et des protéines à doigts de zinc.
CA002240183A 1995-12-12 1996-12-12 Composes de bases de schiff contenant du cobalt Abandoned CA2240183A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/570,761 US6008190A (en) 1994-12-15 1995-12-12 Cobalt Schiff base compounds
US08/570,761 1995-12-12

Publications (1)

Publication Number Publication Date
CA2240183A1 true CA2240183A1 (fr) 1997-06-19

Family

ID=24280957

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002240183A Abandoned CA2240183A1 (fr) 1995-12-12 1996-12-12 Composes de bases de schiff contenant du cobalt

Country Status (6)

Country Link
EP (1) EP1021176A4 (fr)
JP (1) JP2001503376A (fr)
AU (1) AU720841B2 (fr)
CA (1) CA2240183A1 (fr)
IL (1) IL124844A0 (fr)
WO (1) WO1997021431A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008190A (en) * 1994-12-15 1999-12-28 California Institute Of Technology Cobalt Schiff base compounds
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
JP2001521011A (ja) * 1997-10-27 2001-11-06 カリフォルニア・インスティテュート・オブ・テクノロジー 治療成分送達のための磁気共鳴イメージング剤
AU752812B2 (en) * 1997-11-17 2002-10-03 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
AUPQ180499A0 (en) 1999-07-23 1999-08-19 Biomolecular Research Institute Limited Beta-amyloid peptide inhibitors
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
WO2002028441A2 (fr) 2000-10-04 2002-04-11 California Institute Of Technology Agents d'imagerie par resonance magnetique pour la detection et l'etiquetage in vivo de depots amyloides
US7118916B2 (en) * 2002-10-21 2006-10-10 Lifescan, Inc. Method of reducing analysis time of endpoint-type reaction profiles
US8951400B2 (en) 2007-10-17 2015-02-10 Ohmx Corporation Chemistry used in biosensors
EP2210268A4 (fr) 2007-10-17 2012-02-15 Ohmx Corp Chimie novatrice utilisée dans des biocapteurs
WO2011146143A2 (fr) 2010-05-21 2011-11-24 Ohmx Corporation Détection du cancer par dosage de l'activité enzymatique du psa
EP2773650A1 (fr) 2011-11-04 2014-09-10 Ohmx Corporation Nouvelle chimie utilisée dans des biocapteurs
EP3047274A2 (fr) 2013-09-20 2016-07-27 Ohmx Corporation Activité enzymatique du psa : nouveau biomarqueur pour évaluer l'agressivité du cancer de la prostate
CN103936618B (zh) * 2014-04-16 2016-04-20 济南大学 手性四齿氮锌配合物及其制备方法和应用
JP7184282B2 (ja) * 2018-12-13 2022-12-06 株式会社Ihi 金属アセン錯体を含む薬剤送達システム

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451270A (en) * 1982-06-30 1984-05-29 Bend Research, Inc. Absorption process for producing oxygen and nitrogen and solution therefor
US4514522A (en) * 1984-07-27 1985-04-30 University Patents, Inc. Oxygen sorbent
US5106841A (en) * 1986-05-13 1992-04-21 Chai-Tech Corporation Antiviral compositions and method for their use
US4866053A (en) * 1986-05-13 1989-09-12 Chai-Tech Corporation Method of treating a burn employing a metallo-organic cobalt compound
US5756491A (en) * 1986-05-13 1998-05-26 Chai-Tech Corporation Antiviral cobalt-organic compounds
US5142076A (en) * 1986-05-13 1992-08-25 Chai-Tech Corporation Metallo-organic salt compounds and pharmaceutical uses thereof
US4948506A (en) * 1986-07-07 1990-08-14 Bend Research, Inc. Physicochemically functional ultrathin films by interfacial polymerization
US4735634A (en) * 1986-08-28 1988-04-05 Air Products And Chemicals, Inc. Pillared cobalt complexes for oxygen separation
AU5871494A (en) * 1992-12-15 1994-07-04 Redox Pharmaceutical Corporation Antiviral compositions and method for their use
US6008190A (en) * 1994-12-15 1999-12-28 California Institute Of Technology Cobalt Schiff base compounds

Also Published As

Publication number Publication date
AU1333697A (en) 1997-07-03
WO1997021431A1 (fr) 1997-06-19
IL124844A0 (en) 1999-01-26
EP1021176A1 (fr) 2000-07-26
EP1021176A4 (fr) 2001-04-11
JP2001503376A (ja) 2001-03-13
AU720841B2 (en) 2000-06-15

Similar Documents

Publication Publication Date Title
CA2240183A1 (fr) Composes de bases de schiff contenant du cobalt
US6008190A (en) Cobalt Schiff base compounds
WO1996018402A9 (fr) Composes de base de schiff au cobalt
Quiocho et al. Carboxypeptidase A: a protein and an enzyme
Yam et al. A Novel High‐Nuclearity Luminescent Gold (i)–Sulfido Complex
Sundquist et al. Solvolysis reactions of cis-and trans-diamminedichloroplatinum (II) in dimethyl sulfoxide. Structural characterization and DNA binding of trans-bis (ammine) chloro (DMSO) platinum (1+)
Ardizzoia et al. Synthesis, X-ray structure, and catalytic properties of the unprecedented tetranuclear copper (I) species [Cu (dppz)] 4 (Hdppz= 3, 4-diphenylpyrazole)
Bienemann et al. (Guanidine) copper complexes: structural variety and application in bioinorganic chemistry and catalysis
Senge et al. Crystal structure of a remarkably ruffled nonplanar porphyrin (pyridine)[5, 10, 15, 20-tetra (tert-butyl) porphyrinato] zinc (II)
Schoellhorn et al. Unusual four-membered chelate rings of platinum (IV) with a cytosine nucleobase
US5880149A (en) Metal complexes as cysteine protease inhibitors
Lempers et al. Characterization of products from chloro (diethylenetriamine) platinum (1+) chloride and S-adenosyl-L-homocysteine. Evidence for a pH-dependent migration of the platinum moiety from the sulfur atom to the amine group and vice versa
Nicholson et al. Monomeric five-coordinate rhenium diazenido and hydrazido complexes with aromatic thiolate ligands: X-ray structures of [Re (NNC6H4-Br) 2 (SC6H3-2, 5-Me2)(PPh3) 2] and [ReO (NNMePh)(SPh) 3], and of the synthetic precursor [Re (NNC6H4-4-Br) 2Cl (PPh3) 2]
CA1251203A (fr) Complexes d'amino-anthracenediones-platine utiles contre le cancer
Ceriotti et al. Synthesis of bimetallic iron-nickel carbonyl clusters: crystal structure of the iron-nickel carbonyl cluster [N (CH3) 3CH2Ph][Fe3Ni (CO) 8 (. mu.-CO) 4 (. mu. 3-H)]
AU707962B2 (en) Cobalt schiff base compounds
Airey et al. First resolution of a linear chelating tetra (tertiary phosphine): resolution and absolute configurations of enantiomers of (R*, R*)-(±)-1, 1, 4, 7, 10, 10-hexaphenyl-1, 4, 7, 10-tetraphosphadecane
US6780856B2 (en) Towards increased shelf life for cobalt(III) schiff base complexes
Fanchiang et al. Demethylation of methylcobalamin by platinum (IV)/platinum (II) couples. Methyl transfer within a trinuclear intermediate
Dilworth et al. Rhenium complex of a triply deprotonated chelated thiosemicarbazide and its conversion to a nitride complex via a hydrazide intermediate. Crystal structure of [ReCl2 (NH)(NHNH2)(PPh3) 2]
WO1999015535A1 (fr) Complexe binucleaire
Yamaguchi et al. Asymmetric transformation of. alpha.-amino acids promoted by optically active cobalt (III) complexes. 3. Importance of side-chain intramolecular interligand hydrogen bonding on stereoselectivity
Imai et al. Modified picket fence porphyrin Fe (III) and Zn (II) complexes as a model for hemoglobin mutants
Trzeciak et al. Reactions of the ortho-metallated rhodium (I) complex of the formula Rh [P (OC 6 H 4)(OPh) 2][P (OPh) 3] 3 with HX molecules
Matsuda et al. Pressure and temperature effects on the coordination equilibrium of a cobalt (III)[Co (N) 4Cl] system

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued