CA2239624C - Traitement des symptomes negatifs et cognitifs de la schizophrenie par des antagonistes de l'assimilation de la glycine - Google Patents

Traitement des symptomes negatifs et cognitifs de la schizophrenie par des antagonistes de l'assimilation de la glycine Download PDF

Info

Publication number
CA2239624C
CA2239624C CA002239624A CA2239624A CA2239624C CA 2239624 C CA2239624 C CA 2239624C CA 002239624 A CA002239624 A CA 002239624A CA 2239624 A CA2239624 A CA 2239624A CA 2239624 C CA2239624 C CA 2239624C
Authority
CA
Canada
Prior art keywords
glycine
treatment
uptake
gda
schizophrenia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002239624A
Other languages
English (en)
Other versions
CA2239624A1 (fr
Inventor
Daniel C. Javitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1996/019142 external-priority patent/WO1997020553A1/fr
Publication of CA2239624A1 publication Critical patent/CA2239624A1/fr
Application granted granted Critical
Publication of CA2239624C publication Critical patent/CA2239624C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention porte sur l'administration d'un antagoniste de l'assimilation de la glycine pour le traitement des symptômes de la psychose et de la schizophrénie.
CA002239624A 1995-12-07 1996-12-05 Traitement des symptomes negatifs et cognitifs de la schizophrenie par des antagonistes de l'assimilation de la glycine Expired - Fee Related CA2239624C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US836195P 1995-12-07 1995-12-07
US60/008,361 1995-12-07
PCT/US1996/019142 WO1997020553A1 (fr) 1995-12-07 1996-12-05 Traitement des symptomes negatifs et cognitifs de la schizophrenie par des antagonistes de l'assimilation de la glycine

Publications (2)

Publication Number Publication Date
CA2239624A1 CA2239624A1 (fr) 1997-06-12
CA2239624C true CA2239624C (fr) 2007-08-14

Family

ID=38434486

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002239624A Expired - Fee Related CA2239624C (fr) 1995-12-07 1996-12-05 Traitement des symptomes negatifs et cognitifs de la schizophrenie par des antagonistes de l'assimilation de la glycine

Country Status (1)

Country Link
CA (1) CA2239624C (fr)

Also Published As

Publication number Publication date
CA2239624A1 (fr) 1997-06-12

Similar Documents

Publication Publication Date Title
US5837730A (en) Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists
Chang et al. Gabapentin in acute postoperative pain management
US9029410B2 (en) Pharmaceutical compositions for the treatment of movement disorders
KR101122469B1 (ko) 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물
Heresco-Levy et al. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia
US20230000797A1 (en) Compositions and methods for treating motor disorders
Perry et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas
US9999604B2 (en) Compounded solutions of diclofenac and lidocaine and methods
RU2125448C1 (ru) Фармацевтическая композиция и способ ее получения, способ лечения нарушений, развивающихся вследствие нейродегенеративных процессов
Stocchi The hypothesis of the genesis of motor complications and continuous dopaminergic stimulation in the treatment of Parkinson's disease
EP1322305B1 (fr) Utilisation d'acides r-arylpropioniques dans la production de medicaments destines a traiter des maladies de nature rhumatismale
AU2005270573B2 (en) Novel formulation for L-tryptophane comprising carbidopa/benserazide
Kotagale et al. Agmatine prevents development of tolerance to anti-nociceptive effect of ethanol in mice
US20020161048A1 (en) Glycine substitutes and precursors for treating a psychosis
CA2239624C (fr) Traitement des symptomes negatifs et cognitifs de la schizophrenie par des antagonistes de l'assimilation de la glycine
EP1830833B1 (fr) Combinaison d'un inhibiteur de transporteur glycine (glyt1) et d'un antipsychotique destinee au traitement de symptomes de la schizophrenie ainsi que la preparation et l'utilisation de ce compose
Kelmendi et al. The role of the glutamatergic system in the pathophysiology and treatment of mood disorders
MX2011013989A (es) Combinacion farmaceutica.
GB2468424A (en) Composition for the reduction of side-effects of dopaminergic agents

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151207

MKLA Lapsed

Effective date: 20151207