CA2236171A1 - Derives du triterpene ayant une activite immunosuppressive - Google Patents

Derives du triterpene ayant une activite immunosuppressive Download PDF

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Publication number
CA2236171A1
CA2236171A1 CA002236171A CA2236171A CA2236171A1 CA 2236171 A1 CA2236171 A1 CA 2236171A1 CA 002236171 A CA002236171 A CA 002236171A CA 2236171 A CA2236171 A CA 2236171A CA 2236171 A1 CA2236171 A1 CA 2236171A1
Authority
CA
Canada
Prior art keywords
alkyl
defined above
heteroaryl
aryl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002236171A
Other languages
English (en)
Inventor
Kathleen M. Rupprecht
Robert K. Baker
Jianming Bao
Frank Kayser
William H. Parsons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603903.7A external-priority patent/GB9603903D0/en
Priority claimed from GBGB9605161.0A external-priority patent/GB9605161D0/en
Application filed by Individual filed Critical Individual
Publication of CA2236171A1 publication Critical patent/CA2236171A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Les composés de la formule (I) sont utiles comme agents immunosuppresseurs.
CA002236171A 1995-10-31 1996-10-28 Derives du triterpene ayant une activite immunosuppressive Abandoned CA2236171A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US710195P 1995-10-31 1995-10-31
US819195P 1995-10-31 1995-10-31
US60/008,191 1995-10-31
US60/007,101 1995-10-31
GB9603903.7 1996-02-23
GBGB9603903.7A GB9603903D0 (en) 1996-02-23 1996-02-23 Triterpene detivatives with immunosuppressive activity
GB9605161.0 1996-03-12
GBGB9605161.0A GB9605161D0 (en) 1996-03-12 1996-03-12 Triterpene derivatives with immunosuppressant activity

Publications (1)

Publication Number Publication Date
CA2236171A1 true CA2236171A1 (fr) 1997-05-09

Family

ID=27451412

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002236171A Abandoned CA2236171A1 (fr) 1995-10-31 1996-10-28 Derives du triterpene ayant une activite immunosuppressive

Country Status (5)

Country Link
EP (1) EP0891347A4 (fr)
JP (1) JPH11511482A (fr)
AU (1) AU700036B2 (fr)
CA (1) CA2236171A1 (fr)
WO (1) WO1997016438A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU712015B2 (en) * 1995-10-31 1999-10-28 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5874594A (en) * 1996-10-16 1999-02-23 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5952371A (en) * 1996-10-16 1999-09-14 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US5998408A (en) * 1996-10-16 1999-12-07 Merck & Co., Inc. Triterpene derivatives with immunosuppressant activity
US6083980A (en) * 1997-10-17 2000-07-04 Merck & Co., Inc. Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity
US6100293A (en) * 1997-10-17 2000-08-08 Merck & Co., Inc. Tetracyclic triterpene derivatives with immunosuppressant activity
US6022890A (en) * 1997-11-14 2000-02-08 Merck & Co., Inc. Immunosuppressant tetracyclic triterpenes
GB9726630D0 (en) 1997-12-18 1998-02-18 Glaxo Group Ltd Kv2.1 Antagonists
US6051590A (en) * 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
AUPS127202A0 (en) 2002-03-20 2002-04-18 Walter And Eliza Hall Institute Of Medical Research, The Therapeutic ion channel blocking agents and methods of use thereof
JP3905913B2 (ja) 2004-03-31 2007-04-18 森永乳業株式会社 高血糖改善のための医薬及び飲食品
CA2533784C (fr) 2004-03-31 2009-09-15 Morinaga Milk Industry Co., Ltd. Glycoside ayant un squelette de 4-methylergost-7-en-3-ol et agent ameliorant l'hyperglycemie
EP1768662A2 (fr) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
KR100843508B1 (ko) 2004-09-29 2008-07-04 모리나가 뉴교 가부시키가이샤 고혈당 개선용 의약
US8217189B2 (en) 2006-10-04 2012-07-10 Bionomics Limited Chromenone potassium channel blockers and uses thereof
NZ575685A (en) 2006-10-04 2012-04-27 Bionomics Ltd Novel benzofuran potassium channel blockers and uses thereof
CA2701579A1 (fr) 2007-10-04 2009-04-09 Bionomics Ltd. Nouveaux inhibiteurs des canaux potassiques a groupe aryle et leurs utilisations
JP2011522843A (ja) 2008-06-13 2011-08-04 バイオノミクス リミテッド 新規なカリウムチャンネルブロッカー及びその使用
JP6254075B2 (ja) 2011-05-16 2017-12-27 バイオノミックス リミテッド カリウムチャネル遮断剤としてのアミン誘導体
EP2524912A1 (fr) 2011-05-16 2012-11-21 Bionomics Limited Amine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6017794B2 (ja) * 1980-05-16 1985-05-07 ア−ス製薬株式会社 新規ステロイド類

Also Published As

Publication number Publication date
AU7666396A (en) 1997-05-22
EP0891347A1 (fr) 1999-01-20
EP0891347A4 (fr) 1999-04-07
JPH11511482A (ja) 1999-10-05
AU700036B2 (en) 1998-12-17
WO1997016438A1 (fr) 1997-05-09

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