CA2236171A1 - Derives du triterpene ayant une activite immunosuppressive - Google Patents
Derives du triterpene ayant une activite immunosuppressive Download PDFInfo
- Publication number
- CA2236171A1 CA2236171A1 CA002236171A CA2236171A CA2236171A1 CA 2236171 A1 CA2236171 A1 CA 2236171A1 CA 002236171 A CA002236171 A CA 002236171A CA 2236171 A CA2236171 A CA 2236171A CA 2236171 A1 CA2236171 A1 CA 2236171A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- defined above
- heteroaryl
- aryl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Les composés de la formule (I) sont utiles comme agents immunosuppresseurs.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US710195P | 1995-10-31 | 1995-10-31 | |
US819195P | 1995-10-31 | 1995-10-31 | |
US60/008,191 | 1995-10-31 | ||
US60/007,101 | 1995-10-31 | ||
GB9603903.7 | 1996-02-23 | ||
GBGB9603903.7A GB9603903D0 (en) | 1996-02-23 | 1996-02-23 | Triterpene detivatives with immunosuppressive activity |
GB9605161.0 | 1996-03-12 | ||
GBGB9605161.0A GB9605161D0 (en) | 1996-03-12 | 1996-03-12 | Triterpene derivatives with immunosuppressant activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2236171A1 true CA2236171A1 (fr) | 1997-05-09 |
Family
ID=27451412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002236171A Abandoned CA2236171A1 (fr) | 1995-10-31 | 1996-10-28 | Derives du triterpene ayant une activite immunosuppressive |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0891347A4 (fr) |
JP (1) | JPH11511482A (fr) |
AU (1) | AU700036B2 (fr) |
CA (1) | CA2236171A1 (fr) |
WO (1) | WO1997016438A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU712015B2 (en) * | 1995-10-31 | 1999-10-28 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5874594A (en) * | 1996-10-16 | 1999-02-23 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5952371A (en) * | 1996-10-16 | 1999-09-14 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US5998408A (en) * | 1996-10-16 | 1999-12-07 | Merck & Co., Inc. | Triterpene derivatives with immunosuppressant activity |
US6083980A (en) * | 1997-10-17 | 2000-07-04 | Merck & Co., Inc. | Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity |
US6100293A (en) * | 1997-10-17 | 2000-08-08 | Merck & Co., Inc. | Tetracyclic triterpene derivatives with immunosuppressant activity |
US6022890A (en) * | 1997-11-14 | 2000-02-08 | Merck & Co., Inc. | Immunosuppressant tetracyclic triterpenes |
GB9726630D0 (en) | 1997-12-18 | 1998-02-18 | Glaxo Group Ltd | Kv2.1 Antagonists |
US6051590A (en) * | 1999-05-13 | 2000-04-18 | Merck & Co., Inc. | Immunosuppressant tricyclic compounds |
AUPS127202A0 (en) | 2002-03-20 | 2002-04-18 | Walter And Eliza Hall Institute Of Medical Research, The | Therapeutic ion channel blocking agents and methods of use thereof |
JP3905913B2 (ja) | 2004-03-31 | 2007-04-18 | 森永乳業株式会社 | 高血糖改善のための医薬及び飲食品 |
CA2533784C (fr) | 2004-03-31 | 2009-09-15 | Morinaga Milk Industry Co., Ltd. | Glycoside ayant un squelette de 4-methylergost-7-en-3-ol et agent ameliorant l'hyperglycemie |
EP1768662A2 (fr) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence |
KR100843508B1 (ko) | 2004-09-29 | 2008-07-04 | 모리나가 뉴교 가부시키가이샤 | 고혈당 개선용 의약 |
US8217189B2 (en) | 2006-10-04 | 2012-07-10 | Bionomics Limited | Chromenone potassium channel blockers and uses thereof |
NZ575685A (en) | 2006-10-04 | 2012-04-27 | Bionomics Ltd | Novel benzofuran potassium channel blockers and uses thereof |
CA2701579A1 (fr) | 2007-10-04 | 2009-04-09 | Bionomics Ltd. | Nouveaux inhibiteurs des canaux potassiques a groupe aryle et leurs utilisations |
JP2011522843A (ja) | 2008-06-13 | 2011-08-04 | バイオノミクス リミテッド | 新規なカリウムチャンネルブロッカー及びその使用 |
JP6254075B2 (ja) | 2011-05-16 | 2017-12-27 | バイオノミックス リミテッド | カリウムチャネル遮断剤としてのアミン誘導体 |
EP2524912A1 (fr) | 2011-05-16 | 2012-11-21 | Bionomics Limited | Amine derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6017794B2 (ja) * | 1980-05-16 | 1985-05-07 | ア−ス製薬株式会社 | 新規ステロイド類 |
-
1996
- 1996-10-28 WO PCT/US1996/017481 patent/WO1997016438A1/fr not_active Application Discontinuation
- 1996-10-28 JP JP9517550A patent/JPH11511482A/ja active Pending
- 1996-10-28 CA CA002236171A patent/CA2236171A1/fr not_active Abandoned
- 1996-10-28 EP EP96939516A patent/EP0891347A4/fr not_active Withdrawn
- 1996-10-28 AU AU76663/96A patent/AU700036B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU7666396A (en) | 1997-05-22 |
EP0891347A1 (fr) | 1999-01-20 |
EP0891347A4 (fr) | 1999-04-07 |
JPH11511482A (ja) | 1999-10-05 |
AU700036B2 (en) | 1998-12-17 |
WO1997016438A1 (fr) | 1997-05-09 |
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US6051590A (en) | Immunosuppressant tricyclic compounds | |
AU707991B2 (en) | Triterpene derivatives with immunosuppressant activity | |
US5763478A (en) | Triterpene derivatives with immunosuppressant activity | |
US5998408A (en) | Triterpene derivatives with immunosuppressant activity | |
US5874594A (en) | Triterpene derivatives with immunosuppressant activity | |
US5883119A (en) | Triterpene derivatives with immunosuppressant activity | |
WO1998016532A1 (fr) | Derives de triterpene a action immunosuppressive | |
US6022890A (en) | Immunosuppressant tetracyclic triterpenes | |
WO1999025703A1 (fr) | Triterpenes tetracycliques immunodepresseurs | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |