CA2234641A1 - Derives de l'hexahydro-5-imino-1,4-heteroazepine inhibiteurs des synthases de l'oxyde nitrique - Google Patents
Derives de l'hexahydro-5-imino-1,4-heteroazepine inhibiteurs des synthases de l'oxyde nitrique Download PDFInfo
- Publication number
- CA2234641A1 CA2234641A1 CA002234641A CA2234641A CA2234641A1 CA 2234641 A1 CA2234641 A1 CA 2234641A1 CA 002234641 A CA002234641 A CA 002234641A CA 2234641 A CA2234641 A CA 2234641A CA 2234641 A1 CA2234641 A1 CA 2234641A1
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- Prior art keywords
- aryl
- phenyl
- group
- hydrogen
- mono
- Prior art date
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- Abandoned
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
Abstract
L'invention porte sur des composés de formule (I) et leurs sels pharmacocompatibles s'avérant utiles pour le traitement de maladies et affections dues à la synthase de l'oxyde nitrique et notamment de troubles neurodégénératifs, de troubles de la motilité gastro-intestinale et d'inflammations. Ces maladies et affections englobent l'hypotension, le choc septique, le syndrome de choc toxique, l'hémodialyse, le traitement de cancéreux par l'IL-2, la cachexie, l'immuno-suppression accompagnant les thérapies de transplantation, les troubles à caractère auto-immunitaire ou inflammatoire tels que les coups de soleil, l'eczéma ou le psoriasis et les troubles respiratoires tels que la bronchite, l'asthme, les lésions pulmonaires dues à des oxydants et l'emphysème pulmonaire, la glomérulonéphrite, les resténoses, les séquelles inflammatoires d'infections virales, les myocardites, l'insuffisance cardiaque, l'athérosclérose, l'arthrose, la polyarthrite rhumatoïde, l'arthrite aiguë suppurée, les troubles intestinaux chroniques ou inflammatoires, la rectocolite hémorragique, la maladie de Crohn, le lupus érythémateux systémique, des troubles oculaires tels que le glaucome, la rétinite ou l'uvéite, les diabètes de type 1, le diabète sucré insulinodépendant, et la fibrose kystique du pancréas.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US717295P | 1995-11-01 | 1995-11-01 | |
US60/007,172 | 1995-11-01 | ||
US901295P | 1995-12-21 | 1995-12-21 | |
US60/009,012 | 1995-12-21 | ||
GBGB9605162.8A GB9605162D0 (en) | 1996-03-12 | 1996-03-12 | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
GBGB9605700.5A GB9605700D0 (en) | 1996-03-19 | 1996-03-19 | Hexahydro-5-imino,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
GB9605162.8 | 1996-03-19 | ||
GB9605700.5 | 1996-03-19 | ||
PCT/US1996/017447 WO1997016430A1 (fr) | 1995-11-01 | 1996-10-28 | Derives de l'hexahydro-5-imino-1,4-heteroazepine inhibiteurs des synthases de l'oxyde nitrique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2234641A1 true CA2234641A1 (fr) | 1997-05-09 |
Family
ID=27451425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002234641A Abandoned CA2234641A1 (fr) | 1995-11-01 | 1996-10-28 | Derives de l'hexahydro-5-imino-1,4-heteroazepine inhibiteurs des synthases de l'oxyde nitrique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0861238A4 (fr) |
JP (1) | JP3188715B2 (fr) |
AU (1) | AU700078B2 (fr) |
CA (1) | CA2234641A1 (fr) |
WO (1) | WO1997016430A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2136661C1 (ru) * | 1993-10-21 | 1999-09-10 | Джи Ди Сирл энд Ко. | Амидинопроизводные, их применение и фармацевтическая композиция |
WO1996033175A1 (fr) * | 1995-04-20 | 1996-10-24 | G.D. Searle & Co. | Agents amidino cycliques utiles en tant qu'inhibiteurs de synthase de l'oxyde nitrique |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
JP4204657B2 (ja) * | 1997-12-05 | 2009-01-07 | 有限会社ケムフィズ | 糖尿病の予防・治療剤 |
DE19806348A1 (de) * | 1998-02-12 | 1999-08-19 | Schering Ag | 3,4-Dihydrochinolin-Derivate und ihre Verwendung in Arzneimitteln |
US6489323B1 (en) | 1998-06-10 | 2002-12-03 | G.D. Searle & Co. | Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
SE9901530D0 (sv) * | 1999-04-28 | 1999-04-28 | Astra Pharma Prod | Novel compounds |
US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
EP2085400A1 (fr) | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Dérivés d'hétéroarylamide oxazépinopyrimidone substitués |
EP2090578A1 (fr) | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Dérivés d'arylamide diazépinopyrimidone substitués pour le traitement des maladies neurodégénératives causées par une activité anormale de GSK3-beta |
EP2090579A1 (fr) | 2008-01-29 | 2009-08-19 | Sanofi-Aventis | Dérivés d'hétéroarylamide diazépinopyrimidone substitués |
EP2085399A1 (fr) | 2008-01-29 | 2009-08-05 | Sanofi-Aventis | Dérivés d'arylamide oxazépinopyrimidone substitués |
EP2138488A1 (fr) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Dérivés de 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-ones comme inhibiteurs de GSK3-beta utiles pour le traitement de maladies neurodégénératives |
EP2138493A1 (fr) | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Dérivés substitués de pyrimidone |
EP2138495A1 (fr) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Dérivés substitués de pyrimido[2,1-a]isoquinolin-4-one |
EP2138492A1 (fr) | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Dérivés substitués de pyrimidin-4-one |
EP2138494A1 (fr) | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Dérivés substitués d'alkyl pyrimidin-4-one |
EP2138498A1 (fr) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Dérivés tricycliques substitués contre les maladies neurodégénératives |
EP2138485A1 (fr) | 2008-06-26 | 2009-12-30 | sanofi-aventis | Dérivés substitués de N-oxyde pyrazine |
KR20220105661A (ko) * | 2019-11-26 | 2022-07-27 | 길리애드 사이언시즈, 인코포레이티드 | Mcl1 억제제를 제조하기 위한 방법 및 중간체 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH422793A (de) * | 1961-07-20 | 1966-10-31 | Wander Ag Dr A | Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine |
US3444169A (en) * | 1966-01-17 | 1969-05-13 | American Cyanamid Co | Process for 11 - aminodibenz(b,f)(1,4)oxazepines and analogous thiazepines |
SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
AT355025B (de) * | 1974-11-29 | 1980-02-11 | Sandoz Ag | Verfahren zur herstellung neuer 5-amino-7- phenyl-2,3-dihydro-1h-1,4-diazepine |
US4761411A (en) * | 1983-05-18 | 1988-08-02 | Hoechst-Roussel Pharmaceuticals Inc. | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
RU2136661C1 (ru) * | 1993-10-21 | 1999-09-10 | Джи Ди Сирл энд Ко. | Амидинопроизводные, их применение и фармацевтическая композиция |
US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
-
1996
- 1996-10-28 AU AU75287/96A patent/AU700078B2/en not_active Ceased
- 1996-10-28 CA CA002234641A patent/CA2234641A1/fr not_active Abandoned
- 1996-10-28 JP JP51753197A patent/JP3188715B2/ja not_active Expired - Fee Related
- 1996-10-28 WO PCT/US1996/017447 patent/WO1997016430A1/fr not_active Application Discontinuation
- 1996-10-28 EP EP96937836A patent/EP0861238A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP3188715B2 (ja) | 2001-07-16 |
WO1997016430A1 (fr) | 1997-05-09 |
AU7528796A (en) | 1997-05-22 |
JPH11501327A (ja) | 1999-02-02 |
EP0861238A1 (fr) | 1998-09-02 |
EP0861238A4 (fr) | 2000-03-01 |
AU700078B2 (en) | 1998-12-17 |
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