CA2233312C - Piegeurs d'oxygene actifs a base de derives de pterine - Google Patents

Piegeurs d'oxygene actifs a base de derives de pterine Download PDF

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Publication number
CA2233312C
CA2233312C CA002233312A CA2233312A CA2233312C CA 2233312 C CA2233312 C CA 2233312C CA 002233312 A CA002233312 A CA 002233312A CA 2233312 A CA2233312 A CA 2233312A CA 2233312 C CA2233312 C CA 2233312C
Authority
CA
Canada
Prior art keywords
formula
hydrogen atom
integer
group
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002233312A
Other languages
English (en)
Other versions
CA2233312A1 (fr
Inventor
Toshiyuki Arai
Keisuke Makino
Kenjiro Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CMIC Co Ltd
Original Assignee
CMIC Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CMIC Co Ltd filed Critical CMIC Co Ltd
Priority claimed from PCT/JP1997/002649 external-priority patent/WO1998004558A1/fr
Publication of CA2233312A1 publication Critical patent/CA2233312A1/fr
Application granted granted Critical
Publication of CA2233312C publication Critical patent/CA2233312C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des piégeurs d'oxygène actifs à base de dérivés de ptérine actifs représentés par la formule générale suivante (I), qui sont éventuellement cyclisés ou des sels de ces derniers. Dans la formule (I), R<1> et R<2> représentent chacun hydrogène, alkyle C1-4 ou acyle représenté par la formule générale R<3>-CO- (où R<3> représente alkyle C1-4); X représente formyle ou hydroxyméthyle; A représente un groupe représenté par la formule (Ia). Dans cette formule, n est égal à 0, ou un nombre entier supérieur ou égal à 1; à condition que n soit égal à 0 lorsque X représente hydroxyméthyle et R<1> et R<2> représentent chacun hydrogène et X représente formyle lorsque n est un nombre entier supérieur ou égal à 1.
CA002233312A 1996-07-31 1997-07-30 Piegeurs d'oxygene actifs a base de derives de pterine Expired - Fee Related CA2233312C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21804396 1996-07-31
JP8-218043 1996-07-31
PCT/JP1997/002649 WO1998004558A1 (fr) 1996-07-31 1997-07-30 Piegeurs d'oxygene actifs a base de derives de pterine

Publications (2)

Publication Number Publication Date
CA2233312A1 CA2233312A1 (fr) 1998-02-05
CA2233312C true CA2233312C (fr) 2007-10-16

Family

ID=38609820

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002233312A Expired - Fee Related CA2233312C (fr) 1996-07-31 1997-07-30 Piegeurs d'oxygene actifs a base de derives de pterine

Country Status (1)

Country Link
CA (1) CA2233312C (fr)

Also Published As

Publication number Publication date
CA2233312A1 (fr) 1998-02-05

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Effective date: 20090730