CA2229287A1 - Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule - Google Patents

Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule Download PDF

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Publication number
CA2229287A1
CA2229287A1 CA002229287A CA2229287A CA2229287A1 CA 2229287 A1 CA2229287 A1 CA 2229287A1 CA 002229287 A CA002229287 A CA 002229287A CA 2229287 A CA2229287 A CA 2229287A CA 2229287 A1 CA2229287 A1 CA 2229287A1
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CA
Canada
Prior art keywords
receptor
cell
receptors
signalling
signal transduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002229287A
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English (en)
Inventor
Ronald G. Crystal
Marvin C. Gershengorn
Erik S. Falck-Pedersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2229287A1 publication Critical patent/CA2229287A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une cellule in vivo transformée à l'aide d'ADN codant un récepteur de signalisation de cellule, non endogène à celle-ci. Ce récepteur peut activer un processus, endogène à la cellule, de transduction de signal et il peut être activé dans des conditions déterminées, activant ainsi le processus de transduction de signal de manière à réguler une fonction cellulaire commandée par le processus de transduction de signal. Cette invention concerne également un procédé d'expression ectopique d'un récepteur non endogène dans une cellule, ainsi qu'un procédé de régulation d'une fonction cellulaire in vivo, ce dernier consistant à transformer une cellule à l'aide d'ADN codant un récepteur, non endogène à la cellule, de signalisation de cellule, ainsi que décrit ci-dessus, puis, dans des conditions déterminées, à exposer cette cellule à une molécule extracellulaire capable d'activer le récepteur étranger de signalisation de cellule. L'activation du récepteur de signalisation de cellule active le processus de transduction de signal endogène, de manière à réguler une fonction cellulaire commandée par ce processus.
CA002229287A 1995-08-14 1996-08-12 Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule Abandoned CA2229287A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US225495P 1995-08-14 1995-08-14
US60/002,254 1995-08-14

Publications (1)

Publication Number Publication Date
CA2229287A1 true CA2229287A1 (fr) 1997-02-27

Family

ID=21699924

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002229287A Abandoned CA2229287A1 (fr) 1995-08-14 1996-08-12 Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule

Country Status (5)

Country Link
EP (1) EP0845045A4 (fr)
JP (1) JPH11510704A (fr)
AU (1) AU716407B2 (fr)
CA (1) CA2229287A1 (fr)
WO (1) WO1997007233A1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
JP2917998B2 (ja) * 1988-02-05 1999-07-12 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 修飾された肝細胞およびその用途
US5462856A (en) * 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
WO1994010322A1 (fr) * 1992-10-29 1994-05-11 Board Of Regents, The University Of Texas System Transfert et ciblage du gene recepteur ldl induit par l'adenovirus
CA2162602A1 (fr) * 1993-05-10 1994-11-24 James M. Wilson Transfert de gene dans les cellules epitheliales, pancreatiques et biliaires
GB9311854D0 (en) * 1993-06-09 1993-07-28 Medical Res Council Trh receptor action
WO1995016772A1 (fr) * 1993-12-14 1995-06-22 Cornell Research Foundation, Inc. Systeme d'expression du gene d'adenovirus

Also Published As

Publication number Publication date
EP0845045A4 (fr) 1999-11-24
JPH11510704A (ja) 1999-09-21
AU716407B2 (en) 2000-02-24
EP0845045A1 (fr) 1998-06-03
AU6772196A (en) 1997-03-12
WO1997007233A1 (fr) 1997-02-27

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