CA2229126A1 - Opioid antagonists and methods of their use - Google Patents
Opioid antagonists and methods of their use Download PDFInfo
- Publication number
- CA2229126A1 CA2229126A1 CA002229126A CA2229126A CA2229126A1 CA 2229126 A1 CA2229126 A1 CA 2229126A1 CA 002229126 A CA002229126 A CA 002229126A CA 2229126 A CA2229126 A CA 2229126A CA 2229126 A1 CA2229126 A1 CA 2229126A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- opioid
- ala
- gly
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- GWUSZQUVEVMBPI-UHFFFAOYSA-N nimetazepam Chemical compound N=1CC(=O)N(C)C2=CC=C([N+]([O-])=O)C=C2C=1C1=CC=CC=C1 GWUSZQUVEVMBPI-UHFFFAOYSA-N 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 239000004031 partial agonist Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 108010024607 phenylalanylalanine Proteins 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
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- 239000002287 radioligand Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
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- 239000008299 semisolid dosage form Substances 0.000 description 1
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- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/514,451 | 1995-08-11 | ||
| US08/514,451 US5837809A (en) | 1995-08-11 | 1995-08-11 | Mammalian opioid receptor ligand and uses |
| US08/553,058 US5821219A (en) | 1995-08-11 | 1995-11-03 | Opioid antagonists and methods of their use |
| US08/553,058 | 1995-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2229126A1 true CA2229126A1 (en) | 1997-02-27 |
Family
ID=27058205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002229126A Abandoned CA2229126A1 (en) | 1995-08-11 | 1996-08-12 | Opioid antagonists and methods of their use |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5821219A (enExample) |
| EP (1) | EP0843726B1 (enExample) |
| JP (1) | JP3868494B2 (enExample) |
| AT (1) | ATE323160T1 (enExample) |
| AU (1) | AU728001B2 (enExample) |
| CA (1) | CA2229126A1 (enExample) |
| DE (1) | DE69636037D1 (enExample) |
| WO (1) | WO1997007212A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2206192A1 (en) | 1996-06-13 | 1997-12-13 | F. Hoffmann-La Roche Ag | Modulation of lc132 (opioid-like) receptor function |
| EP0813065A3 (en) * | 1996-06-13 | 1998-07-22 | F. Hoffmann-La Roche Ag | Modulation of LC132 (opioid-like) receptor function |
| AU8333998A (en) * | 1997-07-15 | 1999-02-10 | Novo Nordisk A/S | New use of nociceptin |
| AU8334298A (en) * | 1997-07-15 | 1999-02-10 | Novo Nordisk A/S | Nociceptin analogues |
| US5929035A (en) * | 1998-04-14 | 1999-07-27 | Regents Of The University Of Michigan | Methods of treating intestinal disorders |
| GB9815618D0 (en) * | 1998-07-18 | 1998-09-16 | Univ Manchester | Treatment of dyskinesia |
| MA26659A1 (fr) | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
| US6582457B2 (en) * | 2001-02-15 | 2003-06-24 | Radiant Medical, Inc. | Method of controlling body temperature while reducing shivering |
| US6849449B2 (en) * | 2001-03-01 | 2005-02-01 | Regents Of The University Of Michigan | Orphanin FQ receptor nucleic acids |
| JP2005502619A (ja) * | 2001-07-02 | 2005-01-27 | オメロス コーポレイション | オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法 |
| US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
| WO2003030828A2 (en) * | 2001-10-09 | 2003-04-17 | Synvax, Inc. | Nociceptin-based analgesics |
| WO2003093294A2 (en) * | 2002-04-29 | 2003-11-13 | Euro-Celtique S.A. | Conformationally constrained peptides that bind the orl-1 receptor |
| WO2004013292A2 (en) * | 2002-08-02 | 2004-02-12 | Incyte Corporation | Extracellular messengers |
| KR20050043935A (ko) | 2002-09-09 | 2005-05-11 | 얀센 파마슈티카 엔.브이. | Ｏｒｌ-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체 |
| SI2368553T1 (sl) | 2003-04-08 | 2015-05-29 | Progenics Pharmaceuticals, Inc. | Farmacevtske formulacije, vsebujoče metilnatrekson |
| US7173010B2 (en) * | 2003-05-19 | 2007-02-06 | Regents Of The University Of Michigan | Orphanin FQ receptor |
| US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
| CN101171010B (zh) | 2005-03-07 | 2014-09-17 | 芝加哥大学 | 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途 |
| US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| JP2008542375A (ja) | 2005-06-02 | 2008-11-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｏｒｌ−１受容体モジュレーターとして有用な新規３−スピロ環式インドリル誘導体 |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| KR20090083954A (ko) | 2006-11-28 | 2009-08-04 | 얀센 파마슈티카 엔.브이. | 3-(3-아미노-2-(ｒ)-하이드록시프로필)-1-(4-플루오로페닐)-8-(8-메틸나프탈렌-1-일메틸)-1,3,8-트리아자-스피로[4.5]데칸-4-온의 염 |
| PT2565195E (pt) | 2007-03-29 | 2015-07-28 | Wyeth Llc | Antagonistas e receptor opióide periférico e respectivas utilizações |
| CA2945356C (en) | 2007-03-29 | 2021-03-23 | Progenics Pharmaceuticals, Inc. | (r)-n-methylnaltrexone bromide and pharmaceutical compostitions therof useful as peripheral .mu. opioid receptor antagonist |
| PL2137191T3 (pl) | 2007-03-29 | 2016-12-30 | Antagoniści obwodowego receptora opioidowego i ich zastosowania | |
| CA2683598C (en) | 2007-04-09 | 2015-11-17 | Janssen Pharmaceutica Nv | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
| US8278442B2 (en) | 2007-05-22 | 2012-10-02 | Prosidion Limited | Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders |
| US8063247B2 (en) | 2007-09-07 | 2011-11-22 | Prosidion Limited | Bicyclic aryl and heteroaryl receptor modulators |
| CN101959892B (zh) | 2008-02-06 | 2014-01-08 | 普罗热尼奇制药公司 | (r),(r)-2,2’-二-甲基纳曲酮的制备和用途 |
| AU2009225434B2 (en) | 2008-03-21 | 2014-05-22 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| RU2492482C1 (ru) * | 2012-10-08 | 2013-09-10 | Игорь Петрович Папышев | Способ диагностики причины смерти от интоксикации наркотическими веществами группы опиатов |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582820A (en) * | 1982-12-23 | 1986-04-15 | Research Corporation | Orally administered biologically active peptides and proteins |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5017689A (en) * | 1989-07-06 | 1991-05-21 | Arizona Technology Development Corporation | Dynorphin analogs specific for kappa opioid receptors |
| US5512578A (en) * | 1992-09-21 | 1996-04-30 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists |
| US6235496B1 (en) * | 1993-03-08 | 2001-05-22 | Advanced Research & Technology Institute | Nucleic acid encoding mammalian mu opioid receptor |
-
1995
- 1995-11-03 US US08/553,058 patent/US5821219A/en not_active Expired - Lifetime
-
1996
- 1996-08-12 WO PCT/US1996/013305 patent/WO1997007212A1/en not_active Ceased
- 1996-08-12 JP JP50950797A patent/JP3868494B2/ja not_active Expired - Lifetime
- 1996-08-12 CA CA002229126A patent/CA2229126A1/en not_active Abandoned
- 1996-08-12 DE DE69636037T patent/DE69636037D1/de not_active Expired - Lifetime
- 1996-08-12 AT AT96928209T patent/ATE323160T1/de not_active IP Right Cessation
- 1996-08-12 AU AU67769/96A patent/AU728001B2/en not_active Ceased
- 1996-08-12 EP EP96928209A patent/EP0843726B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001520634A (ja) | 2001-10-30 |
| JP3868494B2 (ja) | 2007-01-17 |
| EP0843726B1 (en) | 2006-04-12 |
| EP0843726A1 (en) | 1998-05-27 |
| US5821219A (en) | 1998-10-13 |
| WO1997007212A1 (en) | 1997-02-27 |
| DE69636037D1 (de) | 2006-05-24 |
| AU728001B2 (en) | 2001-01-04 |
| ATE323160T1 (de) | 2006-04-15 |
| AU6776996A (en) | 1997-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |