CA2228844C - Analyse de fluides biologiques par detection des valeurs aberrantes par distances generalisees - Google Patents
Analyse de fluides biologiques par detection des valeurs aberrantes par distances generalisees Download PDFInfo
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- CA2228844C CA2228844C CA002228844A CA2228844A CA2228844C CA 2228844 C CA2228844 C CA 2228844C CA 002228844 A CA002228844 A CA 002228844A CA 2228844 A CA2228844 A CA 2228844A CA 2228844 C CA2228844 C CA 2228844C
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- 239000013060 biological fluid Substances 0.000 title claims abstract description 47
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- 238000013450 outlier detection Methods 0.000 title description 10
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- 230000005855 radiation Effects 0.000 claims abstract description 63
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- 238000012628 principal component regression Methods 0.000 claims description 18
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- 239000000523 sample Substances 0.000 description 141
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- 206010053567 Coagulopathies Diseases 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J2003/2866—Markers; Calibrating of scan
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Theoretical Computer Science (AREA)
- Engineering & Computer Science (AREA)
- Mathematical Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
Un procédé et un appareil permettant de mesurer la concentration d'un produit d'analyse présent dans un fluide biologique. Le procédé consiste à envoyer un rayonnement dans le proche infrarouge sur des échantillons d'étalonnage pour obtenir des données d'étalonnage, à analyser ces données pour identifier et éliminer des valeurs aberrantes, à construire un modèle d'étalonnage, à collecter et analyser des échantillons inconnus pour en identifier et éliminer les valeurs aberrantes, et à prévoir la concentration de valeurs aberrantes dans le produit d'analyse à partir du modèle d'étalonnage. L'analyse des données d'étalonnage comprend le prétraitement des données, la décomposition des données pour éliminer celles qui sont redondantes, et l'identification et l'élimination des valeurs aberrantes à l'aide de distances généralisées. L'appareil (100) comprend une pompe (102) qui fait circuler un échantillon dans des conduites (104) pour remplir une cuve à circulation (106). La lumière provenant d'une source de proche infrarouge (114) est synchronisée avec un détecteur (110) ce qui facilite des mesures à la lumière et dans l'obscurité, puis elle traverse un monochromètre (120) et la cuve à circulation (106) et vient frapper le détecteur (110), ce qui permet de mesurer le rayonnement traversant l'échantillon.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US195095P | 1995-08-07 | 1995-08-07 | |
| US60/001,950 | 1995-08-07 | ||
| US08/587,017 | 1996-01-16 | ||
| US08/587,017 US5606164A (en) | 1996-01-16 | 1996-01-16 | Method and apparatus for biological fluid analyte concentration measurement using generalized distance outlier detection |
| PCT/US1996/012625 WO1997006418A1 (fr) | 1995-08-07 | 1996-08-02 | Analyse de fluides biologiques par detection des valeurs aberrantes par distances generalisees |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2228844A1 CA2228844A1 (fr) | 1997-02-20 |
| CA2228844C true CA2228844C (fr) | 2006-03-14 |
Family
ID=26669720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002228844A Expired - Fee Related CA2228844C (fr) | 1995-08-07 | 1996-08-02 | Analyse de fluides biologiques par detection des valeurs aberrantes par distances generalisees |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0846253A4 (fr) |
| JP (1) | JP3323512B2 (fr) |
| AU (1) | AU711324B2 (fr) |
| CA (1) | CA2228844C (fr) |
| WO (1) | WO1997006418A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5822219A (en) * | 1996-05-13 | 1998-10-13 | Foss Nirsystems, Inc. | System for identifying materials by NIR spectrometry |
| US7383069B2 (en) | 1997-08-14 | 2008-06-03 | Sensys Medical, Inc. | Method of sample control and calibration adjustment for use with a noninvasive analyzer |
| US6115673A (en) * | 1997-08-14 | 2000-09-05 | Instrumentation Metrics, Inc. | Method and apparatus for generating basis sets for use in spectroscopic analysis |
| DE19810917A1 (de) * | 1998-03-13 | 1999-09-16 | Buehler Ag | Automatisches Kalibrationsverfahren |
| SE512540C2 (sv) * | 1998-06-22 | 2000-04-03 | Umetri Ab | Metod och anordning för kalibrering av indata |
| CA2382113A1 (fr) * | 1999-08-31 | 2001-03-08 | Cme Telemetrix Inc. | Procede d'etalonnage d'un dispositif spectroscopique |
| JP4054853B2 (ja) * | 2000-10-17 | 2008-03-05 | 独立行政法人農業・食品産業技術総合研究機構 | 近赤外分光法を用いた血液分析法 |
| WO2003081245A1 (fr) | 2002-03-27 | 2003-10-02 | Biacore Ab | Procede, systeme et programme de detection des interactions de liaison moleculaire impliquant le controle de qualite exprime par des courbes de reponse |
| WO2003083757A2 (fr) * | 2002-03-28 | 2003-10-09 | Epigenomics Ag | Procedes et produits logiciels assurant le controle de qualite des dosages d'acides nucleiques |
| EP1668363A1 (fr) * | 2003-09-24 | 2006-06-14 | Biacore AB | Procede et systeme d'analyse d'interactions moleculaires |
| US8260556B2 (en) * | 2008-08-21 | 2012-09-04 | Bio-Rad Laboratories, Inc. | Calibration surface method for determination on of analyte ratios |
| JP5206251B2 (ja) * | 2008-09-05 | 2013-06-12 | 株式会社ニコン | 利用対象推薦装置、利用対象推薦方法およびプログラム |
| CN102353643A (zh) * | 2011-06-22 | 2012-02-15 | 中国林业科学研究院林产化学工业研究所 | 一种近红外漫反射光谱(nirs)快速测定油茶籽含油率的方法 |
| US9606055B2 (en) * | 2013-01-09 | 2017-03-28 | Ppg Industries Ohio, Inc. | Systems and methods for statistical measurement control of spectrophotometric data |
| WO2018060967A1 (fr) * | 2016-09-29 | 2018-04-05 | Inesc Tec - Instituto De Engenharia De Sistemas E Computadores, Tecnologia E Ciência | Méthodologie d'auto-apprentissage de mégadonnées pour la quantification et la classification précises d'informations spectrales sous une varlabilité complexe et une interférence multi-échelle |
| CN106596465A (zh) * | 2017-03-03 | 2017-04-26 | 东北农业大学 | 一种近红外光谱分析中的异常样本识别方法 |
| EP4290412A3 (fr) * | 2018-09-05 | 2024-01-03 | Sartorius Stedim Data Analytics AB | Procédé mis en uvre par ordinateur, produit de programme informatique et système d'analyse de données |
| DE102019135877B4 (de) * | 2019-12-30 | 2021-09-30 | TRUMPF Venture GmbH | System zur Messung des Vorhandenseins und/oder der Konzentration einer in Körperflüssigkeit gelösten Analysesubstanz |
| CN111967742B (zh) * | 2020-08-05 | 2024-01-23 | 中国矿业大学(北京) | 一种矿井突水水源级次快速判别技术方法 |
| CN112229863A (zh) * | 2020-09-30 | 2021-01-15 | 上海海关工业品与原材料检测技术中心 | 一种铁矿石的原产国或品牌的鉴别方法 |
| CN113702317B (zh) * | 2021-08-30 | 2023-10-27 | 中国农业科学院农业信息研究所 | 一种流域面源污染组分传感器、监测系统及方法 |
| US20240109063A1 (en) * | 2022-09-29 | 2024-04-04 | Illumina, Inc. | Dynamic optical system calibration |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5121338A (en) * | 1988-03-10 | 1992-06-09 | Indiana University Foundation | Method for detecting subpopulations in spectral analysis |
| US4975581A (en) * | 1989-06-21 | 1990-12-04 | University Of New Mexico | Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids |
| EP0535700B1 (fr) * | 1991-10-04 | 1997-03-26 | The Perkin-Elmer Corporation | Méthode appareil pour comparer des spectres |
-
1996
- 1996-08-02 AU AU66448/96A patent/AU711324B2/en not_active Ceased
- 1996-08-02 CA CA002228844A patent/CA2228844C/fr not_active Expired - Fee Related
- 1996-08-02 JP JP50854897A patent/JP3323512B2/ja not_active Expired - Fee Related
- 1996-08-02 EP EP96926226A patent/EP0846253A4/fr not_active Withdrawn
- 1996-08-02 WO PCT/US1996/012625 patent/WO1997006418A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| JP3323512B2 (ja) | 2002-09-09 |
| EP0846253A1 (fr) | 1998-06-10 |
| WO1997006418A1 (fr) | 1997-02-20 |
| AU6644896A (en) | 1997-03-05 |
| JPH11510604A (ja) | 1999-09-14 |
| MX9801056A (es) | 1998-05-31 |
| CA2228844A1 (fr) | 1997-02-20 |
| EP0846253A4 (fr) | 2009-11-11 |
| AU711324B2 (en) | 1999-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |