CA2224799A1 - Homologue du recepteur de edg-2 de l'homme - Google Patents

Homologue du recepteur de edg-2 de l'homme Download PDF

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Publication number
CA2224799A1
CA2224799A1 CA002224799A CA2224799A CA2224799A1 CA 2224799 A1 CA2224799 A1 CA 2224799A1 CA 002224799 A CA002224799 A CA 002224799A CA 2224799 A CA2224799 A CA 2224799A CA 2224799 A1 CA2224799 A1 CA 2224799A1
Authority
CA
Canada
Prior art keywords
hedg
polypeptide
leu
ser
ile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002224799A
Other languages
English (en)
Inventor
Olga Bandman
Karl J. Guegler
Janice Au-Young
Jeffrey J. Seilhamer
Roger Coleman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2224799A1 publication Critical patent/CA2224799A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des séquences nucléotidiques et d'acides aminés identifiant et codant un nouvel homologue du récepteur de EDG-2 (hedg) exprimé dans la synoviale rhumatoïde de l'homme. L'invention concerne également des sondes de détection de séquences nucléotidiques codant des molécules de HEDG ou semblables à HEDG, des molécules antisens par rapport au séquences nucléotidiques codant HEDG, des essais diagnostiques à base de HEDG codant des molécules d'acide nucléique, des vecteur d'expression obtenus par génie génétique et des cellules hôtes servant à produire HEDG purifié, des anticorps capables de se fixer spécifiquement à HEDG, ainsi que des antagonistes et des inhibiteurs possédant une activité de fixation spécifique au polypeptide HEDG.
CA002224799A 1995-06-20 1996-06-20 Homologue du recepteur de edg-2 de l'homme Abandoned CA2224799A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35295P 1995-06-20 1995-06-20
US60/000,352 1995-06-20
US56781795A 1995-12-06 1995-12-06
US08/567,817 1995-12-06

Publications (1)

Publication Number Publication Date
CA2224799A1 true CA2224799A1 (fr) 1997-01-09

Family

ID=26667516

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002224799A Abandoned CA2224799A1 (fr) 1995-06-20 1996-06-20 Homologue du recepteur de edg-2 de l'homme

Country Status (5)

Country Link
EP (1) EP0840787A2 (fr)
JP (1) JPH11508135A (fr)
AU (1) AU718269B2 (fr)
CA (1) CA2224799A1 (fr)
WO (1) WO1997000952A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2759375B1 (fr) * 1997-02-13 1999-04-30 Inst Nat Sante Rech Med Polypeptide a activite de recepteur ob25 specifique des cellules myelinisantes chez le rat, application au criblage de medicaments et medicaments
FR2759374B1 (fr) * 1997-02-13 1999-04-30 Inst Nat Sante Rech Med Polypeptide a activite de recepteur ob25 specifique des cellules myelinisantes chez le rat, application au criblage de medicaments et medicaments
US5912144A (en) * 1997-04-24 1999-06-15 Incyte Pharmaceuticals, Inc. Edg-1-receptor homolog
US6020158A (en) * 1997-05-22 2000-02-01 Allelix Biopharmaceuticals, Inc. Isolated polynucleotide for novel G-protein coupled receptor
WO1999019513A2 (fr) * 1997-10-10 1999-04-22 Lxr Biotechnology, Inc. Procedes pour la detection de composes modulant l'activite d'un recepteur d'acide lysophosphatidique (lpa)
US6485922B1 (en) 1997-10-10 2002-11-26 Atairgin Technologies, Inc. Methods for detecting compounds which modulate the activity of an LPA receptor
DE69825629T2 (de) * 1997-12-30 2005-08-11 Nps Allelix Corp., Mississauga Säugertier edg-7 rezeptor homologen
JP2002500041A (ja) 1997-12-30 2002-01-08 エヌピーエス アレリックス コーポレーション 炎症応答に関与するリゾ脂質受容体の同定
WO1999041375A2 (fr) * 1998-02-12 1999-08-19 Incyte Pharmaceuticals, Inc. Proteines receptrices humaines
CA2340334A1 (fr) * 1998-08-19 2000-03-02 Millenium Pharmaceuticals, Inc. Recepteur couple a la proteine g, appele recepteur 14274, associe a la famille des recepteurs edg
US6812335B1 (en) 1999-03-23 2004-11-02 The Regents Of The University Of California Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same
AU2002246680A1 (en) 2000-12-22 2002-07-30 University Of South Florida Sphingosine 1-phosphate receptor gene, sppr
WO2004044580A1 (fr) * 2002-11-13 2004-05-27 Bayer Healthcare Ag Diagnostics et thérapeutiques destinés à des maladies associées au récepteur humain 2 couplé aux protéines g (edg2) d'acide lysophosphatidique, de différentiation endothéliale
US20070003928A1 (en) * 2002-12-12 2007-01-04 Shuji Hinuma Novel use of edg receptors
EP2153847A4 (fr) * 2007-06-12 2010-09-29 Riken Gène sensible à une maladie des os/articulations et son utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015583A1 (fr) * 1990-04-05 1991-10-17 The American National Red Cross Famille de proteines apparentee a une proteine precoce immediate exprimee par des cellules endotheliales humaines durant la differenciation

Also Published As

Publication number Publication date
AU718269B2 (en) 2000-04-13
AU6388696A (en) 1997-01-22
EP0840787A2 (fr) 1998-05-13
JPH11508135A (ja) 1999-07-21
WO1997000952A3 (fr) 1997-03-20
WO1997000952A2 (fr) 1997-01-09
MX9710409A (es) 1998-07-31

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Legal Events

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FZDE Dead