CA2223414C - Acides d'heteroaryle diol antagonistes des leucotrienes - Google Patents

Acides d'heteroaryle diol antagonistes des leucotrienes Download PDF

Info

Publication number
CA2223414C
CA2223414C CA002223414A CA2223414A CA2223414C CA 2223414 C CA2223414 C CA 2223414C CA 002223414 A CA002223414 A CA 002223414A CA 2223414 A CA2223414 A CA 2223414A CA 2223414 C CA2223414 C CA 2223414C
Authority
CA
Canada
Prior art keywords
phenyl
compound
quinolinyl
methyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002223414A
Other languages
English (en)
Other versions
CA2223414A1 (fr
Inventor
Nathalie Chauret
Claude Dufresne
Yves Gareau
Marc Labelle
Deborah Nicoll-Griffith
Laird Trimble
Xin Xu
James Yergey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Canada Inc
Original Assignee
Merck Frosst Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/475,139 external-priority patent/US5750539A/en
Application filed by Merck Frosst Canada Ltd filed Critical Merck Frosst Canada Ltd
Publication of CA2223414A1 publication Critical patent/CA2223414A1/fr
Application granted granted Critical
Publication of CA2223414C publication Critical patent/CA2223414C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention se rapporte à des composés antagonistes des leucotriènes, qui sont représentés par la formule (I). Ces composés sont utiles comme agents anti-asmathiques, anti-allergiques, anti-inflammatoires et cytoprotecteurs. Ils sont également utiles dans le traitement de l'angine de poitrine, des spasmes cérébraux, de la glomérulonéphrite, de l'hépatite, de l'endotoxémie, de l'uvéité et du rejet d'allogreffes.
CA002223414A 1995-06-07 1996-06-03 Acides d'heteroaryle diol antagonistes des leucotrienes Expired - Fee Related CA2223414C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US475,139 1995-06-07
US08/475,139 US5750539A (en) 1995-06-07 1995-06-07 Heteroaryl diol acids as leukotriene antagonists
PCT/US1996/008446 WO1996040638A1 (fr) 1995-06-07 1996-06-03 Acides d'heteroaryle diol antagonistes des leucotrienes

Publications (2)

Publication Number Publication Date
CA2223414A1 CA2223414A1 (fr) 1996-12-19
CA2223414C true CA2223414C (fr) 2007-08-14

Family

ID=38434464

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002223414A Expired - Fee Related CA2223414C (fr) 1995-06-07 1996-06-03 Acides d'heteroaryle diol antagonistes des leucotrienes

Country Status (1)

Country Link
CA (1) CA2223414C (fr)

Also Published As

Publication number Publication date
CA2223414A1 (fr) 1996-12-19

Similar Documents

Publication Publication Date Title
US5952347A (en) Quinoline leukotriene antagonists
EP0565185B1 (fr) Dérivés de quinoléine comme leukotriène antagonistes
US5428033A (en) Saturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0500360B1 (fr) Des céto-acides contenant une quinoléine comme antagonistes des leukotriènes
AU1378195A (en) Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists
US5132319A (en) 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis
WO1993021168A1 (fr) Alcools benzyliques a substitution thiazole utilises comme antagonistes de leucotrienes
EP0604114B1 (fr) Acides hétérocycliques 5,6-condensés diaryliques comme antagonistes de leucotriene
AU708126B2 (en) Heteroaryl diol acids as leukotriene antagonists
CA2063955C (fr) Derives hydroxylamines du pyrrolo¬1,2-a|indole, inhibiteurs de la biosynthese de leucotriene
US5438141A (en) Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
EP0480708B1 (fr) Hydroxyalkylquinoline ether acide comme antagoniste leukotriènes
US5334597A (en) Indole carbamates as leukotriene antagonists
US5149703A (en) Quinoline-substituted chromans and related compounds as leukotriene antagonists
US5350760A (en) Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
CA2283101C (fr) Antagonistes des leucotrienes a base de quinoline
CA2223414C (fr) Acides d'heteroaryle diol antagonistes des leucotrienes
WO1993021169A1 (fr) Alcools benzyliques substitues par benzothiazole, utilises comme antagonistes de leucotrienes
US5212180A (en) Quinoline-containing ketoacids as leukotriene antagonists
WO1995003309A1 (fr) Aryl-bicyclooctanes employes comme inhibiteurs de la biosynthese des leucotrienes
WO1995003300A1 (fr) Heteroaryl-quinoleines utilisees comme inhibiteurs de la biosynthese des leucotrienes
WO1994005658A1 (fr) Lactones d'heteroarylnaphtalene utiles comme inhibiteurs de la biosynthese de leucotrienes
WO1994005656A1 (fr) Lactones phenylnaphtalene utiles comme inhibiteurs de la biosynthese du leucotriene

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed