WO1993021168A1 - Alcools benzyliques a substitution thiazole utilises comme antagonistes de leucotrienes - Google Patents

Alcools benzyliques a substitution thiazole utilises comme antagonistes de leucotrienes Download PDF

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Publication number
WO1993021168A1
WO1993021168A1 PCT/CA1993/000146 CA9300146W WO9321168A1 WO 1993021168 A1 WO1993021168 A1 WO 1993021168A1 CA 9300146 W CA9300146 W CA 9300146W WO 9321168 A1 WO9321168 A1 WO 9321168A1
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WO
WIPO (PCT)
Prior art keywords
compound
lower alkyl
substituted
formula
benzyl
Prior art date
Application number
PCT/CA1993/000146
Other languages
English (en)
Inventor
Robert Zamboni
Claude Dufresne
Cheuk K. Lau
Original Assignee
Merck Frosst Canada Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc. filed Critical Merck Frosst Canada Inc.
Publication of WO1993021168A1 publication Critical patent/WO1993021168A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Des composés de formule (I) agissent comme antagonistes par rapport à l'activité des leucotriènes. Ces composés sont utiles comme agents anti-asthmatiques, antiallergiques, anti-inflammatoires et cytoprotecteurs. Ils peuvent également être utilisés pour traiter les angines, les spasmes cérébraux, la néphrite glomérulaire, l'hépatite, l'endotoxémie, l'uvéite et les rejets d'allogreffes.
PCT/CA1993/000146 1992-04-10 1993-04-02 Alcools benzyliques a substitution thiazole utilises comme antagonistes de leucotrienes WO1993021168A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86663592A 1992-04-10 1992-04-10
US866,635 1992-04-10

Publications (1)

Publication Number Publication Date
WO1993021168A1 true WO1993021168A1 (fr) 1993-10-28

Family

ID=25348042

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1993/000146 WO1993021168A1 (fr) 1992-04-10 1993-04-02 Alcools benzyliques a substitution thiazole utilises comme antagonistes de leucotrienes

Country Status (3)

Country Link
AU (1) AU3884893A (fr)
CA (1) CA2132724A1 (fr)
WO (1) WO1993021168A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021555A2 (fr) * 1997-10-27 1999-05-06 Takeda Chemical Industries, Ltd. Antagonistes des recepteurs de l'adenosine a¿3?
US6140330A (en) * 1996-07-31 2000-10-31 Otsuka Pharmaceutical Company, Limited Thiazole derivative
US7279477B2 (en) 2001-01-26 2007-10-09 Chugai Seiyaku Kabushiki Kaisha Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7285562B2 (en) 2003-08-01 2007-10-23 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
US7385063B2 (en) 2001-01-26 2008-06-10 Chugai Seiyaku Kabushiki Kaisha Method for preparing imidazole derivatives
US7449482B2 (en) 2003-08-01 2008-11-11 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors
US7524969B2 (en) 2001-01-26 2009-04-28 Chugai Seiyaku Kabushiki Kaisha Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7696365B2 (en) 2003-08-01 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7718808B2 (en) 2003-12-26 2010-05-18 Kyowa Hakko Kirin Co., Ltd. Thiazole derivatives
US7723366B2 (en) 2001-02-20 2010-05-25 Chugai Seiyaku Kabushiki Kaisha Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases
US7786145B2 (en) 2003-08-01 2010-08-31 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0219436A2 (fr) * 1985-10-16 1987-04-22 Mitsubishi Kasei Corporation Dérivés thiazoliques et antagoniste leucotrinique comprenant la même chose comme les ingrédients effectifs
GB2190377A (en) * 1986-05-14 1987-11-18 Merck Frosst Canada Inc Phenyldithiaalkanedioic acids as leukotriene antagonists
EP0318085A2 (fr) * 1987-11-25 1989-05-31 Merck Frosst Canada Inc. Acides hétérazole-dialcanoiques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0219436A2 (fr) * 1985-10-16 1987-04-22 Mitsubishi Kasei Corporation Dérivés thiazoliques et antagoniste leucotrinique comprenant la même chose comme les ingrédients effectifs
GB2190377A (en) * 1986-05-14 1987-11-18 Merck Frosst Canada Inc Phenyldithiaalkanedioic acids as leukotriene antagonists
EP0318085A2 (fr) * 1987-11-25 1989-05-31 Merck Frosst Canada Inc. Acides hétérazole-dialcanoiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 113, no. 21, 19 January 1990, Columbus, Ohio, US; abstract no. 191338a, page 724 ; *

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140330A (en) * 1996-07-31 2000-10-31 Otsuka Pharmaceutical Company, Limited Thiazole derivative
WO1999021555A3 (fr) * 1997-10-27 1999-07-22 Takeda Chemical Industries Ltd Antagonistes des recepteurs de l'adenosine a¿3?
US6620825B1 (en) 1997-10-27 2003-09-16 Takeda Chemical Industries, Ltd. Adenosine A3 receptor antagonists
WO1999021555A2 (fr) * 1997-10-27 1999-05-06 Takeda Chemical Industries, Ltd. Antagonistes des recepteurs de l'adenosine a¿3?
US7279477B2 (en) 2001-01-26 2007-10-09 Chugai Seiyaku Kabushiki Kaisha Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7385063B2 (en) 2001-01-26 2008-06-10 Chugai Seiyaku Kabushiki Kaisha Method for preparing imidazole derivatives
US8119819B2 (en) 2001-01-26 2012-02-21 Chugai Seiyaku Kabushiki Kaisha Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7524969B2 (en) 2001-01-26 2009-04-28 Chugai Seiyaku Kabushiki Kaisha Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7723366B2 (en) 2001-02-20 2010-05-25 Chugai Seiyaku Kabushiki Kaisha Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases
US8110686B2 (en) 2001-02-20 2012-02-07 Chugai Seiyaki Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US7285562B2 (en) 2003-08-01 2007-10-23 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
US7786145B2 (en) 2003-08-01 2010-08-31 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors
US7897615B2 (en) 2003-08-01 2011-03-01 Chugai Sciyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
US8080665B2 (en) 2003-08-01 2011-12-20 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors
US7696365B2 (en) 2003-08-01 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors
US7449482B2 (en) 2003-08-01 2008-11-11 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors
US7718808B2 (en) 2003-12-26 2010-05-18 Kyowa Hakko Kirin Co., Ltd. Thiazole derivatives
US7880013B2 (en) 2003-12-26 2011-02-01 Kyowa Hakko Kirin Co., Ltd. Thiazole derivatives
US8420827B2 (en) 2003-12-26 2013-04-16 Kyowa Hakko Kirin Co., Ltd. Thiazole derivatives
US8889718B2 (en) 2003-12-26 2014-11-18 Kyowa Hakko Kirin Co., Ltd. Thiazole derivatives
EP3002283A1 (fr) 2003-12-26 2016-04-06 Kyowa Hakko Kirin Co., Ltd. Dérivés de thiazole

Also Published As

Publication number Publication date
AU3884893A (en) 1993-11-18
CA2132724A1 (fr) 1993-10-28

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