CA2216126C - Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening - Google Patents

Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening Download PDF

Info

Publication number
CA2216126C
CA2216126C CA002216126A CA2216126A CA2216126C CA 2216126 C CA2216126 C CA 2216126C CA 002216126 A CA002216126 A CA 002216126A CA 2216126 A CA2216126 A CA 2216126A CA 2216126 C CA2216126 C CA 2216126C
Authority
CA
Canada
Prior art keywords
viral
host cell
patient
resistance test
indicator gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002216126A
Other languages
English (en)
French (fr)
Other versions
CA2216126A1 (en
Inventor
Daniel J. Capon
Christos John Petropoulous
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Virologic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virologic Inc filed Critical Virologic Inc
Publication of CA2216126A1 publication Critical patent/CA2216126A1/en
Application granted granted Critical
Publication of CA2216126C publication Critical patent/CA2216126C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002216126A 1996-01-29 1997-01-29 Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening Expired - Lifetime CA2216126C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59300996A 1996-01-29 1996-01-29
US08/593,009 1996-01-29
PCT/US1997/001609 WO1997027319A1 (en) 1996-01-29 1997-01-29 Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening

Publications (2)

Publication Number Publication Date
CA2216126A1 CA2216126A1 (en) 1997-07-31
CA2216126C true CA2216126C (en) 2009-03-31

Family

ID=24372979

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002216126A Expired - Lifetime CA2216126C (en) 1996-01-29 1997-01-29 Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening

Country Status (18)

Country Link
EP (2) EP1170380B1 (OSRAM)
JP (1) JP4183749B2 (OSRAM)
KR (1) KR100537153B1 (OSRAM)
CN (1) CN1263867C (OSRAM)
AP (1) AP9801360A0 (OSRAM)
AT (1) ATE447621T1 (OSRAM)
AU (1) AU732255B2 (OSRAM)
CA (1) CA2216126C (OSRAM)
DE (2) DE69711584T2 (OSRAM)
EA (1) EA005426B1 (OSRAM)
ES (1) ES2175355T3 (OSRAM)
HU (1) HUP9900388A3 (OSRAM)
IL (1) IL125464A (OSRAM)
NO (1) NO983421L (OSRAM)
NZ (1) NZ331376A (OSRAM)
PL (1) PL328068A1 (OSRAM)
RO (1) RO118887B1 (OSRAM)
WO (1) WO1997027319A1 (OSRAM)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69332002T2 (de) 1992-08-25 2002-12-19 Monsanto Co Hydroxyethylaminosulfonamide verwendbar als Inhibitoren retroviraler Proteasen
EP0877937B1 (en) 1996-01-26 2002-05-22 Virco N.V. Method of assessing the chemotherapy of hiv-positive patients based on the phenotypic drug sensitivity of the patient's hiv strains
US6242187B1 (en) 1996-01-29 2001-06-05 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
AU8897698A (en) * 1997-07-30 1999-02-22 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
WO1999051776A1 (en) * 1998-04-07 1999-10-14 Southern Research Institute High-throughput method for screening for antiviral activity
BR9911600A (pt) * 1998-05-26 2001-02-13 Virologic Inc Recursos e métodos para monitoração de terapia antiretroviral inibidora de transcriptase reversa de não nucleosìdeo
US7037644B1 (en) 1998-05-26 2006-05-02 Virologic, Inc. Means and methods for monitoring non-nucleoside reverse transcriptase inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
US20030148307A1 (en) 1998-06-19 2003-08-07 Department Of Health & Human Services, C/O Centers Of Disease Control And Prevention Method and kit for detecting resistance to antiviral drugs
ES2237923T3 (es) * 1998-06-19 2005-08-01 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Metodo para detectar resistencia a los medicamentos antivirales.
US6787126B1 (en) 1998-06-19 2004-09-07 The United States Of America As Represented By The Department Of Health And Human Services Method and kit for detecting resistance to antiviral drugs
BR9912209A (pt) * 1998-06-24 2002-11-05 Virologic Inc Recursos e métodos para monitoração de terapia anti-retroviral inibidora de transcriptase reversa de nucleosìdeo e guia de decisões terapêuticas no tratamento de hiv/aids
ES2246859T3 (es) 1999-05-28 2006-03-01 Virco Bvba Nuevos perfiles mutacionales en la transcriptasa inversa del vih-1 correlacionadas con una resistencia fenotipica a farmacos.
WO2002022781A2 (en) * 2000-09-15 2002-03-21 Virologic, Inc. Non-nucleoside reverse transcriptase inhibitor as antiretroviral therapy
AU2002226316B2 (en) 2000-10-20 2008-06-26 Virco Bvba Mutational profiles in HIV-1 reverse transcriptase correlated with phenotypic drug resistance
AU1234402A (en) * 2000-10-20 2002-04-29 Virco Nv Establishment of biological cut-off values for predicting resistance to therapy
US7247439B1 (en) 2001-06-04 2007-07-24 Monogram Biosciences, Inc. Method of evaluating a patient antibody response to envelope proteins of a virus
US7097970B2 (en) 2001-06-04 2006-08-29 Monogram Biosciences, Inc. Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs
EP1446498B1 (en) 2001-11-08 2008-03-12 Tibotec Pharmaceuticals Ltd. Protease assay for therapeutic drug monitoring
CA2490862A1 (en) 2002-07-01 2004-01-08 Tibotec Pharmaceuticals Ltd. Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance
WO2004003223A2 (en) 2002-07-01 2004-01-08 Tibotec Pharmaceuticals Ltd. New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance
DE20218008U1 (de) 2002-11-21 2003-03-06 FESTO AG & Co., 73734 Esslingen Anordnung von mehreren Handhabungsvorrichtungen
US8603736B2 (en) 2004-06-07 2013-12-10 Monogram Biosciences, Inc. Compositions and methods for determining resistance to inhibitors of virus entry using recombinant virus assays
EP2522757A1 (en) 2005-02-18 2012-11-14 Monogram BioSciences, Inc. Methods and compositions for determining anti-HIV drug susceptibility and replication capacity of HIV
WO2006089045A2 (en) 2005-02-18 2006-08-24 Monogram Biosciences, Inc. Methods and compositions for determining hypersusceptibility of hiv-1 to non-nucleoside reverse transcriptase inhibitors
EP2458019A3 (en) 2005-05-27 2012-07-25 Monogram BioSciences, Inc. Methods and compositions for determining resistance of HIV-1 to protease inhibitors
WO2006133267A2 (en) 2005-06-06 2006-12-14 Monogram Biosciences, Inc. Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs
US9506121B2 (en) 2005-06-06 2016-11-29 Monogram Biosciences, Inc. Methods for determining resistance or susceptibility to HIV entry inhibitors
US8114585B2 (en) 2006-06-13 2012-02-14 Monogram Biosciences, Inc. Method for determining human immunodeficiency virus (HIV) coreceptor utilization by examining gp41 molecular determinants
ES2639568T3 (es) * 2007-01-23 2017-10-27 Janssen Pharmaceutica Nv Método para diseñar un régimen farmacológico para pacientes infectados con el VIH
WO2008106115A2 (en) 2007-02-26 2008-09-04 Monogram Biosciences, Inc. Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy
WO2018030534A1 (ja) * 2016-08-10 2018-02-15 国立研究開発法人理化学研究所 Ｂ型肝炎治療用組成物、及びｂ型肝炎ウイルスの複製活性の評価方法
RU2646472C1 (ru) * 2016-10-07 2018-03-05 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации Способ оценки эффективности терапии инфекции вызванной вирусом герпеса человека 6 типа у детей
WO2018126042A1 (en) * 2016-12-29 2018-07-05 Virongy L.L.C. Retro- and lenti-hbv hybrid vectors and constructs
CN109722465B (zh) * 2019-01-07 2022-02-01 福建省疾病预防控制中心(福建省健康教育促进中心、福建省卫生检验检测中心) 一种hiv耐药检测载体和构建方法
JP7773731B2 (ja) * 2020-06-24 2025-11-20 シァメン・ユニヴァーシティ 薬物スクリーニングモデル及びＨＢＶ ｃｃｃＤＮＡを標的化する方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291893A1 (en) * 1987-05-19 1988-11-23 The Du Pont Merck Pharmaceutical Company Stable human cell lines expressing an indicator gene product under virus-specific genetic controls
DE68921034D1 (de) * 1988-09-27 1995-03-23 Dana Farber Cancer Inst Inc Vektor, der ein replikationskompetentes HIV-I-Provirus und ein heterologes Gen enthält.
HU209835B (en) * 1988-12-07 1994-11-28 Univ Osaka Res Found Method for producing of retrovirus protease, reverse transcriptase and integrase
ES2110411T3 (es) * 1989-08-25 1998-02-16 Chiron Corp Metodos para cultivar el virus de la hepatitis c (hcv) en lineas celulares de linfocitos b o t.
GB8923123D0 (en) * 1989-10-13 1989-11-29 Connaught Lab A vaccine for human immunodeficiency virus
FR2700169B1 (fr) * 1993-01-04 1995-03-24 Transgene Sa Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine.
US5645982A (en) * 1993-08-19 1997-07-08 Systemix, Inc. Method for screening potential therapeutically effective antiviral agents
AU1923795A (en) * 1994-02-18 1995-09-04 University Of Washington Methods and compositions for screening for anti-aids drugs
US5733543A (en) * 1994-04-29 1998-03-31 Nabel; Gary J. Introduction of HIV-protective genes into cells by particle-mediated gene transfer
CA2158977A1 (en) * 1994-05-09 1995-11-10 James G. Respess Retroviral vectors having a reduced recombination rate
US5837464A (en) * 1996-01-29 1998-11-17 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
AU8897698A (en) * 1997-07-30 1999-02-22 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening

Also Published As

Publication number Publication date
CA2216126A1 (en) 1997-07-31
EP1170380A3 (en) 2003-05-02
JP2000503849A (ja) 2000-04-04
CN1263867C (zh) 2006-07-12
NZ331376A (en) 2000-03-27
HUP9900388A3 (en) 2005-03-29
AU1952897A (en) 1997-08-20
EP0852626A1 (en) 1998-07-15
DE69711584D1 (de) 2002-05-08
IL125464A0 (en) 1999-03-12
ATE447621T1 (de) 2009-11-15
EP0852626A4 (en) 1999-08-25
IL125464A (en) 2007-12-03
NO983421L (no) 1998-09-25
NO983421D0 (no) 1998-07-24
EP0852626B1 (en) 2002-04-03
PL328068A1 (en) 1999-01-04
KR19990082129A (ko) 1999-11-15
JP4183749B2 (ja) 2008-11-19
HUP9900388A2 (hu) 1999-05-28
EP1170380A2 (en) 2002-01-09
RO118887B1 (ro) 2003-12-30
DE69711584T2 (de) 2002-11-07
EP1170380B1 (en) 2009-11-04
EA005426B1 (ru) 2005-02-24
WO1997027319A1 (en) 1997-07-31
AP9801360A0 (en) 1998-12-31
ES2175355T3 (es) 2002-11-16
EA199800669A1 (ru) 1999-02-25
AU732255B2 (en) 2001-04-12
KR100537153B1 (ko) 2006-12-15
CN1213407A (zh) 1999-04-07
DE69739645D1 (de) 2009-12-17

Similar Documents

Publication Publication Date Title
CA2216126C (en) Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
US5837464A (en) Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
US7279279B2 (en) Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
Geraghty et al. Cell type‐dependence for Vpu function
US6653081B2 (en) Methods for monitoring antiretroviral therapy and guiding therapeutic decision in the treatment of HIV/AIDS
US20160312315A1 (en) Methods and Compositions for Determining Virus Susceptibility to Integrase Inhibitors
JP2001512036A (ja) 抗ウイルス薬剤感受性および耐性を測定するための組成物および方法、並びに抗ウイルス薬剤をスクリーニングするための組成物および方法
US20090176202A1 (en) Methods of Detecting Inhibitors of VIF-Mediated APOBEC3G Degradation and HIV
AU776535B2 (en) Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
US6869759B1 (en) Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
MXPA98006104A (en) Compositions and methods to determine the susceptibility and resistance to antiviral drug and the antivi drug examination
ZA200210003B (en) Means and methods for monitoring antiretroviral therapy and guiding therapeutic decisions in the treatment of hiv/aids.
CA2601922C (en) Methods and compositions for determining anti-hiv drug susceptibility and replication capacity of hiv
Copeland et al. Cytochemical analysis of human T cell leukaemia virus 1 LTR-regulated β-galactosidase gene expression using a novel integrated cell system
Hout et al. Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIVKU-1bMC33) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathogenic for pig-tailed macaques

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170130