CA2213253C - Synthesis of (+)-pancratistatin - Google Patents

Synthesis of (+)-pancratistatin Download PDF

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Publication number
CA2213253C
CA2213253C CA002213253A CA2213253A CA2213253C CA 2213253 C CA2213253 C CA 2213253C CA 002213253 A CA002213253 A CA 002213253A CA 2213253 A CA2213253 A CA 2213253A CA 2213253 C CA2213253 C CA 2213253C
Authority
CA
Canada
Prior art keywords
yield
thf
amide
formula
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002213253A
Other languages
English (en)
French (fr)
Other versions
CA2213253A1 (en
Inventor
Tomas Hudlicky
Xinrong Tian
Kurt Konigsberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Tech Intellectual Properties Inc
Original Assignee
Virginia Tech Intellectual Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties Inc filed Critical Virginia Tech Intellectual Properties Inc
Publication of CA2213253A1 publication Critical patent/CA2213253A1/en
Application granted granted Critical
Publication of CA2213253C publication Critical patent/CA2213253C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
CA002213253A 1995-02-16 1996-02-14 Synthesis of (+)-pancratistatin Expired - Lifetime CA2213253C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/389,477 1995-02-16
US08/389,477 US5627280A (en) 1995-02-16 1995-02-16 Synthesis of (+)-pancratistatin
PCT/US1996/001861 WO1996025415A1 (en) 1995-02-16 1996-02-14 Synthesis of (+)-pancratistatin

Publications (2)

Publication Number Publication Date
CA2213253A1 CA2213253A1 (en) 1996-08-22
CA2213253C true CA2213253C (en) 2006-07-11

Family

ID=23538426

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002213253A Expired - Lifetime CA2213253C (en) 1995-02-16 1996-02-14 Synthesis of (+)-pancratistatin

Country Status (8)

Country Link
US (1) US5627280A (da)
EP (1) EP0809643B1 (da)
AT (1) ATE207070T1 (da)
CA (1) CA2213253C (da)
DE (1) DE69616029T2 (da)
DK (1) DK0809643T3 (da)
ES (1) ES2166881T3 (da)
WO (1) WO1996025415A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002050023A2 (en) * 2000-12-21 2002-06-27 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of The Arizona State University Synthesis of pancrastistatin
CN105622686B (zh) * 2016-01-11 2021-01-01 江苏省中国科学院植物研究所 一种生物碱化合物及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995035303A1 (en) * 1994-06-17 1995-12-28 Virginia Tech Intellectual Properties, Inc. Synthesis of conduritol epoxides and aziridines and methods of using such to synthesize higher disaccharides

Also Published As

Publication number Publication date
DE69616029D1 (de) 2001-11-22
ATE207070T1 (de) 2001-11-15
DK0809643T3 (da) 2002-02-04
CA2213253A1 (en) 1996-08-22
ES2166881T3 (es) 2002-05-01
US5627280A (en) 1997-05-06
EP0809643B1 (en) 2001-10-17
DE69616029T2 (de) 2002-06-20
EP0809643A1 (en) 1997-12-03
WO1996025415A1 (en) 1996-08-22
MX9706110A (es) 1997-11-29

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Effective date: 20160215