CA2209227A1 - Nouvelles chemokines exprimees dans le pancreas - Google Patents

Nouvelles chemokines exprimees dans le pancreas

Info

Publication number
CA2209227A1
CA2209227A1 CA002209227A CA2209227A CA2209227A1 CA 2209227 A1 CA2209227 A1 CA 2209227A1 CA 002209227 A CA002209227 A CA 002209227A CA 2209227 A CA2209227 A CA 2209227A CA 2209227 A1 CA2209227 A1 CA 2209227A1
Authority
CA
Canada
Prior art keywords
panec
pancreas
cells
polypeptide
biological sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002209227A
Other languages
English (en)
Inventor
Olga Bandman
Roger Coleman
Craig G. Wilde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23543735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2209227(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2209227A1 publication Critical patent/CA2209227A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/067—Pancreatitis or colitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention se rapporte à des séquences nucléotidiques et d'acides aminés qui identifient et codent de nouvelles chémokines exprimées (PANEC-1 et PANEC-2) provenant des cellules pancréatiques humaines. L'invention se rapporte également à des molécules antisens par rapport aux séquences nucléotidiques qui codent les chémokines PANEC-1 et PANEC-2, à des vecteurs d'expression destinés à la production de PANEC-1 et PANEC-2 purifiées, à des anticorps capables de se lier spécifiquement aux PANEC-1 et PANEC-2, à des oligonucléotides ou sondes d'hybridation destinés à la détection de séquences nucléotidiques codant les PANEC-1 et PANEC-2, à des cellules hôtes génétiquement modifiées pour exprimer les PANEC-1 et PANEC-2, et à des essais diagnostiques relatifs à l'activation des chémokines, où interviennent des molécules d'acide nucléique codant les PANEC-1 et PANEC-2 et des anticorps capables de se lier spécifiquement à la protéine.
CA002209227A 1995-02-17 1996-02-16 Nouvelles chemokines exprimees dans le pancreas Abandoned CA2209227A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/390,740 1995-02-17
US08/390,740 US7005509B1 (en) 1995-02-17 1995-02-17 Chemokine PANEC-1 polynucleotides and compositions and methods related thereto

Publications (1)

Publication Number Publication Date
CA2209227A1 true CA2209227A1 (fr) 1996-08-22

Family

ID=23543735

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002209227A Abandoned CA2209227A1 (fr) 1995-02-17 1996-02-16 Nouvelles chemokines exprimees dans le pancreas

Country Status (6)

Country Link
US (6) US7005509B1 (fr)
EP (1) EP0809699A1 (fr)
JP (1) JPH10512154A (fr)
AU (1) AU5024696A (fr)
CA (1) CA2209227A1 (fr)
WO (1) WO1996025497A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970705635A (ko) 1994-08-23 1997-10-09 벤슨 로버트 에이치 사람 케모킨 베타-9(Human chemokine beta-9)
US7005509B1 (en) 1995-02-17 2006-02-28 Incyte Corporation Chemokine PANEC-1 polynucleotides and compositions and methods related thereto
US7265201B1 (en) 1995-06-23 2007-09-04 Millennium Pharmaceuticals, Inc. Human chemotactic cytokine
EP0951549A1 (fr) * 1996-10-02 1999-10-27 Schering Corporation Chemokines mammaliennes
WO1998031809A1 (fr) * 1997-01-20 1998-07-23 Shionogi & Co., Ltd. Slc humaine de chemokine cc
WO1998056818A1 (fr) * 1997-06-11 1998-12-17 Genetics Institute, Inc. Proteines humaines l105 et polynucleotides codant lesdites proteines
US6084071A (en) * 1997-06-11 2000-07-04 Genetics Institute Human L105 polypeptides and polynucleotides encoding same
US6153441A (en) * 1998-02-17 2000-11-28 Smithkline Beecham Corporation Methods of screening for agonists and antagonists for human CCR7 receptor and CKβ-9 ligand and interaction thereof
CA2451271A1 (fr) * 2001-06-22 2003-01-03 Alexander V. Lukashin Acides nucleiques et polypeptides pancam

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4430318A (en) * 1978-11-29 1984-02-07 The United States Of America As Represented By The Department Of Health And Human Services Immunoassay utilizing 125 I Protein A
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
CA1202962A (fr) 1982-10-19 1986-04-08 David P. Clifford Derives de substitution de n-phenyl-n'-benzoyl-uree; leur utilisation comme insecticides et comme acaricides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US6001649A (en) * 1990-11-29 1999-12-14 Societe Anonyme: Elf Sanofi Chemokine NC28 (monocyte chemotactic protein-3, MCP-3) polypeptides and their recombinant production
WO1992019737A1 (fr) 1991-05-09 1992-11-12 Dainippon Pharmaceutical Co., Ltd. Procede de preparation d'un polypeptide de facteur chimiotactique de monocyte et souche utilisee pour cette preparation
JPH05276986A (ja) * 1992-04-02 1993-10-26 Sumitomo Electric Ind Ltd 単球遊走性サイトカインに対する抗体
WO1995004067A1 (fr) * 1993-07-29 1995-02-09 The Regents Of The University Of Michigan Marqueurs utilises pour la detection de rearrangement du chromosome 16
CA2171761C (fr) * 1993-09-14 2011-11-15 Timothy John Williams Cytokine chimiotactique appelee eotaxine, pour eosinophiles
US5981230A (en) 1994-08-23 1999-11-09 Human Genome Sciences, Inc. Polynucleotide encoding chemokine β-4
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
KR970705635A (ko) 1994-08-23 1997-10-09 벤슨 로버트 에이치 사람 케모킨 베타-9(Human chemokine beta-9)
JPH10508742A (ja) 1994-08-23 1998-09-02 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド ヒトケモカインポリペプチド
US7005509B1 (en) 1995-02-17 2006-02-28 Incyte Corporation Chemokine PANEC-1 polynucleotides and compositions and methods related thereto
US6403782B1 (en) 1995-06-22 2002-06-11 President And Fellows Of Harvard College Nucleic acid encoding eotaxin
US7265201B1 (en) 1995-06-23 2007-09-04 Millennium Pharmaceuticals, Inc. Human chemotactic cytokine
WO1997012914A1 (fr) 1995-10-05 1997-04-10 Shionogi & Co., Ltd. Nouvelle chemokine cc humaine
US5672694A (en) * 1995-10-24 1997-09-30 University Of Iowa Research Foundation β-sarcoglycan nucleic acid sequence, and nucleic acid probes
US5733732A (en) * 1996-01-03 1998-03-31 University Of Iowa Research Foundation Methods for detecting primary adhalinopathy
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EP0951549A1 (fr) 1996-10-02 1999-10-27 Schering Corporation Chemokines mammaliennes
JP2002533402A (ja) 1998-12-31 2002-10-08 カイロン コーポレイション 癌を処置するためおよび樹状細胞の走化性を媒介するための方法

Also Published As

Publication number Publication date
US20020155545A1 (en) 2002-10-24
US9090687B2 (en) 2015-07-28
MX9706158A (es) 1997-11-29
US20130224769A1 (en) 2013-08-29
US7005509B1 (en) 2006-02-28
EP0809699A1 (fr) 1997-12-03
WO1996025497A1 (fr) 1996-08-22
US8617551B2 (en) 2013-12-31
US7803373B2 (en) 2010-09-28
US20140227275A1 (en) 2014-08-14
US7396652B2 (en) 2008-07-08
US20080292636A1 (en) 2008-11-27
AU5024696A (en) 1996-09-04
JPH10512154A (ja) 1998-11-24
US20070078260A1 (en) 2007-04-05

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