CA2208233A1 - Utilisation de molecules se fixant a cnh-ii et/ou simulant cnh-ii dans la prevention et/ou le traitement des etats inflammatoires - Google Patents
Utilisation de molecules se fixant a cnh-ii et/ou simulant cnh-ii dans la prevention et/ou le traitement des etats inflammatoiresInfo
- Publication number
- CA2208233A1 CA2208233A1 CA002208233A CA2208233A CA2208233A1 CA 2208233 A1 CA2208233 A1 CA 2208233A1 CA 002208233 A CA002208233 A CA 002208233A CA 2208233 A CA2208233 A CA 2208233A CA 2208233 A1 CA2208233 A1 CA 2208233A1
- Authority
- CA
- Canada
- Prior art keywords
- mhc
- molecules
- lps
- cell
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
Abstract
La présente invention se rapporte à des molécules se fixant à CMH-II (complexe majeur d'histocompatibilité) et/ou simulant CMH-II, ces molécules servant à intervenir dans l'interaction entre un stimulus d'activation des cellules porteuses de CMH-II telles que les phagocytes et des molécules de CMH-II liées aux cellules. Ces molécules interviennent également dans l'interaction entre un lipopolysaccharide ou LPS dans un complexe avec d'autres molécules, telles que CD14 et LBP (protéines de liaisons de LPS), et des molécules CMH-II liées aux cellules, ou dans l'interaction entre des produits provenant de bactéries Gram positif ou des complexes de produits provenant de bactéries Gram positif avec des molécules telles que CD14, et des molécules de CMH-II liées aux cellules. La molécule de fixation de CMH-II peut être n'importe quel anticorps ou fragment d'anticorps anti-CMH-II, ou n'importe quelle molécule dérivée de cet anticorps tel que des molécules humanisées, plus spécifiques ou autres molécules mises au point. La molécule de fixation de CMH-II peut être sélectionnée dans le groupe constitué par CD14, des fragments de celui-ci, des versions modifiées de celui-ci ou des peptides possédant des propriétés de fixation à CMH-II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94203755 | 1994-12-23 | ||
EP94203755.7 | 1994-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2208233A1 true CA2208233A1 (fr) | 1996-07-04 |
Family
ID=8217495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002208233A Abandoned CA2208233A1 (fr) | 1994-12-23 | 1995-12-27 | Utilisation de molecules se fixant a cnh-ii et/ou simulant cnh-ii dans la prevention et/ou le traitement des etats inflammatoires |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0800534A2 (fr) |
JP (1) | JPH10511652A (fr) |
CN (1) | CN1171117A (fr) |
AU (1) | AU4347696A (fr) |
BR (1) | BR9510554A (fr) |
CA (1) | CA2208233A1 (fr) |
CZ (1) | CZ186897A3 (fr) |
HU (1) | HUT77468A (fr) |
PL (1) | PL320922A1 (fr) |
SK (1) | SK80697A3 (fr) |
WO (1) | WO1996020215A2 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5719296A (en) * | 1995-10-30 | 1998-02-17 | Merck & Co., Inc. | Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins |
US5817757A (en) * | 1995-10-30 | 1998-10-06 | Merck & Co., Inc. | Inhibitors of peptide binding to MHO class II proteins |
US5840835A (en) * | 1995-10-30 | 1998-11-24 | Merck & Co., Inc. | Inhibitors of peptide binding to MHC class II proteins |
US6458354B1 (en) | 1996-03-28 | 2002-10-01 | The Johns Hopkins University | Molecular complexes which modify immune responses |
AU729406B2 (en) | 1996-03-28 | 2001-02-01 | Johns Hopkins University, The | Soluble divalent and multivalent heterodimeric analogs of proteins |
US6268411B1 (en) | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
EP0893507A1 (fr) * | 1997-07-25 | 1999-01-27 | Institut Gustave Roussy | Utilisation de ligands de MHC classe II (CD4 et LAG-3) comme adjuvants pour la vaccination de LAG-3 dans le traitement du cancer |
HU228957B1 (en) * | 2001-07-02 | 2013-07-29 | Aimsco Ltd | Use anti-hla-antibody for production of pharmaceutical compotisions for the treatment of diseases involving prolierative immune response |
GB0201896D0 (en) * | 2002-01-28 | 2002-03-13 | Ice Biolog Ltd | Treatment |
MXPA04007311A (es) * | 2002-01-28 | 2005-05-16 | Aimsco Ltd | Tratamiento de ms con suero de cabra. |
ES2232273B1 (es) * | 2003-03-21 | 2006-07-16 | Jose Manuel Fernandez-Real Lemos | Nuevas aplicaciones terapeuticas de la glucoproteina cd14s. |
AU2004241069B2 (en) * | 2003-05-15 | 2010-09-09 | Genentech, Inc. | Methods and compositions for the prevention and treatment of sepsis |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0068790B1 (fr) * | 1981-06-25 | 1986-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Méthode immunothérapeutique allèle spécifique et forme de dosage |
GB8310403D0 (en) * | 1983-04-18 | 1983-05-25 | Mach B F | Cotransformed mouse cells |
JPS6225994A (ja) * | 1985-05-30 | 1987-02-03 | ジエネテイツク システムズ コ−ポレイシヨン | Hlaタイプ分け用モノクロ−ナル抗体 |
JPS63275526A (ja) * | 1987-05-03 | 1988-11-14 | Hiroshi Okajima | Hivウイルス中和抗体 |
FR2658197B1 (fr) * | 1990-02-14 | 1992-05-22 | Inst Nat Sante Rech Med | Anticorps monoclonaux restreints reconnaissant un peptide associe a un antigene du complexe majeur d'histocompatibilite - applications au diagnostic et au traitement. |
DE4029227A1 (de) * | 1990-09-14 | 1992-03-19 | Imtox Gmbh | Arzneimittel enthaltend cd14 |
WO1993010220A1 (fr) * | 1991-11-19 | 1993-05-27 | Anergen, Inc. | Molecules solubles du complexe majeur d'histocompatibilite et leurs utilisations |
CA2133758A1 (fr) * | 1992-04-06 | 1993-10-14 | Sanna M. Goyert | Nouveau mode de traitement de la septicemie utilisant une forme soluble d'antigene myelomonocytaire cd14 recombinant |
KR0169751B1 (ko) * | 1992-10-15 | 1999-01-15 | 마에다 카쭈노수케 | 주요 조직 적합성 항원 클라스ii 단백질의 제조방법 및 그것을 고정화한 재료 |
AU695124B2 (en) * | 1993-05-28 | 1998-08-06 | Scripps Research Institute, The | Methods and compositions for inhibiting CD14 mediated cell activation |
US6180377B1 (en) * | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
-
1995
- 1995-12-27 CN CN95196985A patent/CN1171117A/zh active Pending
- 1995-12-27 AU AU43476/96A patent/AU4347696A/en not_active Abandoned
- 1995-12-27 CZ CZ971868A patent/CZ186897A3/cs unknown
- 1995-12-27 BR BR9510554A patent/BR9510554A/pt not_active Application Discontinuation
- 1995-12-27 EP EP95942207A patent/EP0800534A2/fr not_active Withdrawn
- 1995-12-27 CA CA002208233A patent/CA2208233A1/fr not_active Abandoned
- 1995-12-27 SK SK806-97A patent/SK80697A3/sk unknown
- 1995-12-27 PL PL95320922A patent/PL320922A1/xx unknown
- 1995-12-27 HU HU9800269A patent/HUT77468A/hu unknown
- 1995-12-27 WO PCT/EP1995/005164 patent/WO1996020215A2/fr not_active Application Discontinuation
- 1995-12-27 JP JP8520220A patent/JPH10511652A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
SK80697A3 (en) | 1997-12-10 |
CN1171117A (zh) | 1998-01-21 |
JPH10511652A (ja) | 1998-11-10 |
WO1996020215A3 (fr) | 1996-10-10 |
HUT77468A (hu) | 1998-05-28 |
WO1996020215A2 (fr) | 1996-07-04 |
AU4347696A (en) | 1996-07-19 |
BR9510554A (pt) | 1999-06-29 |
CZ186897A3 (cs) | 1998-03-18 |
EP0800534A2 (fr) | 1997-10-15 |
PL320922A1 (en) | 1997-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |