CA2201347A1 - Inhibiteurs de la farnesyl-transferase proteique - Google Patents

Inhibiteurs de la farnesyl-transferase proteique

Info

Publication number
CA2201347A1
CA2201347A1 CA 2201347 CA2201347A CA2201347A1 CA 2201347 A1 CA2201347 A1 CA 2201347A1 CA 2201347 CA2201347 CA 2201347 CA 2201347 A CA2201347 A CA 2201347A CA 2201347 A1 CA2201347 A1 CA 2201347A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
aryl
heterocycle
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2201347
Other languages
English (en)
Inventor
Samuel L. Graham
S. Jane Desolms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/315,151 external-priority patent/US5491164A/en
Application filed by Individual filed Critical Individual
Publication of CA2201347A1 publication Critical patent/CA2201347A1/fr
Abandoned legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des analogues de dipeptides inhibiteurs de la farnésylation du Ras. Ces inhibiteurs de la farnésyl-transférase protéique sont caractérisés par l'inclusion d'une amine cyclique dans le squelette du dipeptide. L'invention concerne également des compositions chimiothérapeutiques à base de ces inhibiteurs de la farnésyl-transférase protéique et leurs procédés de production.
CA 2201347 1994-09-29 1995-09-25 Inhibiteurs de la farnesyl-transferase proteique Abandoned CA2201347A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US315,151 1994-09-29
US08/315,151 US5491164A (en) 1994-09-29 1994-09-29 Inhibitors of farnesyl-protein transferase
PCT/US1995/012284 WO1996009820A1 (fr) 1994-09-29 1995-09-25 Inhibiteurs de la farnesyl-transferase proteique

Publications (1)

Publication Number Publication Date
CA2201347A1 true CA2201347A1 (fr) 1996-04-04

Family

ID=29405753

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2201347 Abandoned CA2201347A1 (fr) 1994-09-29 1995-09-25 Inhibiteurs de la farnesyl-transferase proteique

Country Status (1)

Country Link
CA (1) CA2201347A1 (fr)

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Legal Events

Date Code Title Description
FZDE Dead