CA2199018A1 - Procede de fabrication d'un liposome lyophilise - Google Patents

Procede de fabrication d'un liposome lyophilise

Info

Publication number
CA2199018A1
CA2199018A1 CA002199018A CA2199018A CA2199018A1 CA 2199018 A1 CA2199018 A1 CA 2199018A1 CA 002199018 A CA002199018 A CA 002199018A CA 2199018 A CA2199018 A CA 2199018A CA 2199018 A1 CA2199018 A1 CA 2199018A1
Authority
CA
Canada
Prior art keywords
liposomes
mixture
product
lyophilized
bioactive agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002199018A
Other languages
English (en)
Inventor
Laura M. Edgerly-Pflug
Royden M. Coe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002199018A priority Critical patent/CA2199018A1/fr
Publication of CA2199018A1 publication Critical patent/CA2199018A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Abstract

Méthode pour la formation d'un produit de liposome lyophilisé par la combinaison d'un lipide avec une solution aqueuse contenant un agent siccatif protecteur, sans addition de solvant organique, par l'agitation du mélange de façon à former une population de liposomes et par la lyophilisation du mélange de façon à former un produit de liposome lyophilisé. Cette invention porte aussi sur les produits lyophilisés obtenus par cette méthode, ainsi que sur les liposomes préparés par la reconstitution du produit lyophilisé. On peut effectuer l'étape de la lyophilisation à des températures de séchage plus élevées, ce qui, entre autres choses, améliore la rentabilité du procédé.
CA002199018A 1994-09-23 1994-09-23 Procede de fabrication d'un liposome lyophilise Abandoned CA2199018A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002199018A CA2199018A1 (fr) 1994-09-23 1994-09-23 Procede de fabrication d'un liposome lyophilise

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002199018A CA2199018A1 (fr) 1994-09-23 1994-09-23 Procede de fabrication d'un liposome lyophilise

Publications (1)

Publication Number Publication Date
CA2199018A1 true CA2199018A1 (fr) 1996-03-28

Family

ID=4160086

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002199018A Abandoned CA2199018A1 (fr) 1994-09-23 1994-09-23 Procede de fabrication d'un liposome lyophilise

Country Status (1)

Country Link
CA (1) CA2199018A1 (fr)

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 19990923