CA2195238A1 - Anticorps se fixant a une molecule cd4 a conformation modifiee, induite par fixation du virus de l'immunodeficience humaine - Google Patents
Anticorps se fixant a une molecule cd4 a conformation modifiee, induite par fixation du virus de l'immunodeficience humaineInfo
- Publication number
- CA2195238A1 CA2195238A1 CA002195238A CA2195238A CA2195238A1 CA 2195238 A1 CA2195238 A1 CA 2195238A1 CA 002195238 A CA002195238 A CA 002195238A CA 2195238 A CA2195238 A CA 2195238A CA 2195238 A1 CA2195238 A1 CA 2195238A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- cell
- molecule
- fab
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Cette invention se rapporte à des anticorps qui se fixent à une forme de CD4 modifée dans sa conformation, induite sur la surface d'une cellule CD4?+¿, par contact de ladite cellule avec le virus de l'immunodéficience humaine (VIH) ou avec une protéine enveloppe de ce virus (par exemple gp120), mais qui ne se lient pas à la forme native de CD4 sur la surface d'une cellule avant d'entrer en contact avec le VIH ou avec une protéine enveloppe de ce virus. Les anticorps préférés de cette invention sont les fragments Fab monoclonaux 3-47 et 3-51. Des compositions pharmaceutiques ainsi que des procédés de diagnostic, de triage et de thérapie utilisant ces anticorps sont également décrits. Les anticorps de cette invention servent à détecter la présence d'une forme de CD4 à conformation modifée sur la surface d'une cellule, à identifier des agents qui inhibent ou qui induisent la production de cette forme de CD4 à conformation modifée après fixation de la protéine gp120, ou à inhiber l'infection de cellules CD4?+¿ par le VIH. Des molécules qui expriment au moins un épitope exprimé sur une forme de CD4 à conformation modifiée, induites sur la surface d'une cellule CD4?+¿, après contact de la cellule avec le VIH, ou avec une protéine enveloppe de ce virus, font également l'objet de cette invention. De telles molécules peuvent être utilisées pour produire des anticorps de cette invention ou pour induire chez un sujet une réponse par anticorps qui inhibe l'infection des cellules de ce sujet par le VIH.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27708094A | 1994-07-19 | 1994-07-19 | |
| US08/277,080 | 1994-07-19 | ||
| US30590394A | 1994-09-13 | 1994-09-13 | |
| US08/305,903 | 1994-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2195238A1 true CA2195238A1 (fr) | 1996-02-01 |
Family
ID=26958290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002195238A Abandoned CA2195238A1 (fr) | 1994-07-19 | 1995-07-19 | Anticorps se fixant a une molecule cd4 a conformation modifiee, induite par fixation du virus de l'immunodeficience humaine |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0774000A1 (fr) |
| JP (1) | JPH10505490A (fr) |
| AU (1) | AU3196895A (fr) |
| CA (1) | CA2195238A1 (fr) |
| WO (1) | WO1996002647A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6300129B1 (en) * | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU9395398A (en) * | 1997-09-19 | 1999-04-12 | Chiron Corporation | Subtractive protein screening for gene identification |
| US7910798B2 (en) | 2006-03-31 | 2011-03-22 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU653366B2 (en) * | 1990-09-28 | 1994-09-29 | Hospital For Joint Diseases | Method for inhibiting the infectivity of human immunodeficiency virus |
| AU6080794A (en) * | 1992-12-31 | 1994-08-15 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Antibodies directed against binding-associated epitopes |
-
1995
- 1995-07-19 WO PCT/US1995/009114 patent/WO1996002647A1/fr not_active Application Discontinuation
- 1995-07-19 AU AU31968/95A patent/AU3196895A/en not_active Abandoned
- 1995-07-19 EP EP95928088A patent/EP0774000A1/fr not_active Withdrawn
- 1995-07-19 CA CA002195238A patent/CA2195238A1/fr not_active Abandoned
- 1995-07-19 JP JP8505251A patent/JPH10505490A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996002647A1 (fr) | 1996-02-01 |
| JPH10505490A (ja) | 1998-06-02 |
| EP0774000A1 (fr) | 1997-05-21 |
| AU3196895A (en) | 1996-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |