CA2194576C - Compositions a base d'oxytretracycline a action prolongee - Google Patents

Compositions a base d'oxytretracycline a action prolongee Download PDF

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Publication number
CA2194576C
CA2194576C CA002194576A CA2194576A CA2194576C CA 2194576 C CA2194576 C CA 2194576C CA 002194576 A CA002194576 A CA 002194576A CA 2194576 A CA2194576 A CA 2194576A CA 2194576 C CA2194576 C CA 2194576C
Authority
CA
Canada
Prior art keywords
amount
magnesium
polyethylene glycol
composition
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002194576A
Other languages
English (en)
Other versions
CA2194576A1 (fr
Inventor
Alan Patterson
Drew Holmes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norbrook Laboratories Ltd
Original Assignee
Norbrook Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9413873A external-priority patent/GB9413873D0/en
Application filed by Norbrook Laboratories Ltd filed Critical Norbrook Laboratories Ltd
Publication of CA2194576A1 publication Critical patent/CA2194576A1/fr
Application granted granted Critical
Publication of CA2194576C publication Critical patent/CA2194576C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Une composition injectable présentant un effet résiduel supérieur avec des effets préjudiciables réduits tels que la douleur sur le site d'injection, le gonflement, l'irritation des tissus ou la nécrose, et contenant comme principe actif un composé de tétracycline, soit comme base libre soit comme sel de celle-ci avec un acide physiologiquement acceptable, transformé en complexe avec une dose sensiblement équimolaire d'un composé de magnésium et solubilisé dans un système de solvants miscibles à l'eau comprenant soit (i) a) du glycérol formal en une quantité comprise entre environ 10 et environ 50 % v/v; avec b) du polyethylène-glycol en une quantité comprise entre environ 1 et 15 % v/v; ou (ii) environ 25 à environ 75 % v/v de N-méthylpyrrolidone, ladite composition contenant facultativement un agent modificateur de pH en une dose suffisante pour maintenir un pH physiochimiquement acceptable, le solde étant constitué d'eau q.s.
CA002194576A 1994-07-09 1995-07-05 Compositions a base d'oxytretracycline a action prolongee Expired - Lifetime CA2194576C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9413873A GB9413873D0 (en) 1994-07-09 1994-07-09 Long-acting oxytetracycline composition
GB9413873.2 1994-07-09
PCT/GB1995/001583 WO1996001634A1 (fr) 1994-07-09 1995-07-05 Compositions a base d'oxytretracycline a action prolongee

Publications (2)

Publication Number Publication Date
CA2194576A1 CA2194576A1 (fr) 1996-01-25
CA2194576C true CA2194576C (fr) 2006-09-12

Family

ID=36999258

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002194576A Expired - Lifetime CA2194576C (fr) 1994-07-09 1995-07-05 Compositions a base d'oxytretracycline a action prolongee

Country Status (1)

Country Link
CA (1) CA2194576C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112301089A (zh) * 2020-09-17 2021-02-02 河北圣雪大成制药有限责任公司 一种盐酸土霉素微生物限度检验方法

Also Published As

Publication number Publication date
CA2194576A1 (fr) 1996-01-25

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Effective date: 20150706