CA2194168C - Systeme ameliore d'administration pharmaceutique par bioadhesion - Google Patents

Systeme ameliore d'administration pharmaceutique par bioadhesion Download PDF

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Publication number
CA2194168C
CA2194168C CA002194168A CA2194168A CA2194168C CA 2194168 C CA2194168 C CA 2194168C CA 002194168 A CA002194168 A CA 002194168A CA 2194168 A CA2194168 A CA 2194168A CA 2194168 C CA2194168 C CA 2194168C
Authority
CA
Canada
Prior art keywords
phase
composition
active pharmaceutical
volume
chewing gum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002194168A
Other languages
English (en)
Other versions
CA2194168A1 (fr
Inventor
Robert C. Cuca
Keith S. Lienhop
Thomas Charles Riley, Jr.
R. Saul Levinson
Mitchell I. Kirschner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kv Pharmaceutical Co
Original Assignee
Kv Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/441,297 external-priority patent/US5554380A/en
Application filed by Kv Pharmaceutical Co filed Critical Kv Pharmaceutical Co
Publication of CA2194168A1 publication Critical patent/CA2194168A1/fr
Application granted granted Critical
Publication of CA2194168C publication Critical patent/CA2194168C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un système d'administration de médicaments bioadhérents solides ou semi-solides, oralement ingérables. Il se compose d'un système eau-dans-l'huile présentant au moins deux phases. Une phase comporte un volume de 25 % à 75 % de phase hydrophile interne, et l'autre phase comporte un volume de 25 % à 75 % de phase hydrophobe externe. La phase hydrophobe externe est constituée de trois composants: a) un émulsifiant, b) un ester de glycéride et c) une substance cireuse.
CA002194168A 1994-08-04 1995-07-31 Systeme ameliore d'administration pharmaceutique par bioadhesion Expired - Lifetime CA2194168C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28390494A 1994-08-04 1994-08-04
US08/441,297 1995-05-15
US08/283,904 1995-05-15
US08/441,297 US5554380A (en) 1994-08-04 1995-05-15 Bioadhesive pharmaceutical delivery system
PCT/US1995/009483 WO1996003975A1 (fr) 1994-08-04 1995-07-31 Systeme ameliore d'administration pharmaceutique par bioadhesion

Publications (2)

Publication Number Publication Date
CA2194168A1 CA2194168A1 (fr) 1996-02-15
CA2194168C true CA2194168C (fr) 2007-04-10

Family

ID=38007169

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002194168A Expired - Lifetime CA2194168C (fr) 1994-08-04 1995-07-31 Systeme ameliore d'administration pharmaceutique par bioadhesion

Country Status (1)

Country Link
CA (1) CA2194168C (fr)

Also Published As

Publication number Publication date
CA2194168A1 (fr) 1996-02-15

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Effective date: 20150731