CA2191984A1 - Composes d'aroyloxy polyiodes substitues par alpha-(cycloalkyle, aryle et aralkyle) - Google Patents

Composes d'aroyloxy polyiodes substitues par alpha-(cycloalkyle, aryle et aralkyle)

Info

Publication number
CA2191984A1
CA2191984A1 CA002191984A CA2191984A CA2191984A1 CA 2191984 A1 CA2191984 A1 CA 2191984A1 CA 002191984 A CA002191984 A CA 002191984A CA 2191984 A CA2191984 A CA 2191984A CA 2191984 A1 CA2191984 A1 CA 2191984A1
Authority
CA
Canada
Prior art keywords
acid
compound
acetylamino
oxo
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002191984A
Other languages
English (en)
Inventor
Edward R. Bacon
Carl R. Illig
Irennegbe K. Osifo
Xin Peng
John L. Toner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosystems LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2191984A1 publication Critical patent/CA2191984A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des composés de structure (I) où m est égal à 1, 2, 3, ou 4; Z-(-COO-)-¿m? est le reste d'un monoacide ou d'un polyacide aromatique polyiodé; R?1¿ représente H, alkyle, fluoroalkyle, cycloalkyle, aryle, aralkyle, alcoxyalkyle ou acétamidoalkyle; n est un entier compris entre 0 et 20; R?2¿ représente cycloalkyle ou aryle; et R?3¿, R?4¿ et R?5¿ représentent indépendamment l'un de l'autre H, alkyle, fluoroalkyle, cycloalkyle, aryle, aralkyle, halogène, hydroxy, acylamino, acétamidoalkyle, cyano, sulfonyle, carboxamido ou sulfonamido. Ces composés sont utilisés en tant qu'agents de contraste pour rayons X dans des compositions et des procédés d'imagerie par rayons X destinés au diagnostic médical.
CA002191984A 1994-06-24 1995-06-09 Composes d'aroyloxy polyiodes substitues par alpha-(cycloalkyle, aryle et aralkyle) Abandoned CA2191984A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26560394A 1994-06-24 1994-06-24
US08/265,603 1994-06-24

Publications (1)

Publication Number Publication Date
CA2191984A1 true CA2191984A1 (fr) 1996-01-04

Family

ID=23011132

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002191984A Abandoned CA2191984A1 (fr) 1994-06-24 1995-06-09 Composes d'aroyloxy polyiodes substitues par alpha-(cycloalkyle, aryle et aralkyle)

Country Status (8)

Country Link
EP (1) EP0767779A1 (fr)
JP (1) JPH10502084A (fr)
AU (1) AU2703595A (fr)
CA (1) CA2191984A1 (fr)
FI (1) FI965096A0 (fr)
IL (1) IL114306A0 (fr)
NO (1) NO965302L (fr)
WO (1) WO1996000211A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030152519A1 (en) * 2001-11-07 2003-08-14 Reinhard Koenig Methods for vascular imaging using nanoparticulate contrast agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL239757A (fr) * 1958-06-03
US3144479A (en) * 1958-08-07 1964-08-11 Chemie Linz Ag New iodine-containing benzoic acid esters
US5322679A (en) * 1992-12-16 1994-06-21 Sterling Winthrop Inc. Iodinated aroyloxy esters

Also Published As

Publication number Publication date
EP0767779A1 (fr) 1997-04-16
JPH10502084A (ja) 1998-02-24
NO965302D0 (no) 1996-12-11
NO965302L (no) 1996-12-11
AU2703595A (en) 1996-01-19
WO1996000211A1 (fr) 1996-01-04
FI965096A (fi) 1996-12-18
FI965096A0 (fi) 1996-12-18
IL114306A0 (en) 1995-10-31

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Legal Events

Date Code Title Description
FZDE Discontinued