CA2190379C - Adsorbants de chromatographie utilisant des ligands mercapto heterocycliques - Google Patents

Adsorbants de chromatographie utilisant des ligands mercapto heterocycliques Download PDF

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Publication number
CA2190379C
CA2190379C CA002190379A CA2190379A CA2190379C CA 2190379 C CA2190379 C CA 2190379C CA 002190379 A CA002190379 A CA 002190379A CA 2190379 A CA2190379 A CA 2190379A CA 2190379 C CA2190379 C CA 2190379C
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CA
Canada
Prior art keywords
ligand
group
solid support
support material
chromatography adsorbent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002190379A
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English (en)
Other versions
CA2190379A1 (fr
Inventor
Alexander Schwarz
Meir Wilchek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pall Corp
Original Assignee
Pall Corp
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Filing date
Publication date
Priority claimed from US08/243,861 external-priority patent/US5502022A/en
Application filed by Pall Corp filed Critical Pall Corp
Publication of CA2190379A1 publication Critical patent/CA2190379A1/fr
Application granted granted Critical
Publication of CA2190379C publication Critical patent/CA2190379C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

Adsorbant de chromatographie par pseudoaffinité destiné à être utilisé pour obtenir une absorption sélective d'immunoglobulines. Dans une forme d'exécution, l'adsorbant comprend: (a) une matière de support solide; et (b) un ligand immobilisé à la surface de cette matière de support solide, le ligand étant un composé de formule (II), dans laquelle Y¿1? est sélectionné dans le groupe composé de S, SCH¿3??+¿, O, NH, NCH¿3?, CH¿2? et CR¿1?R¿2?, où au moins un élément parmi R¿1? et R¿2? n'est pas hydrogène; où Y¿2?, Y¿3? et Y¿4? sont chacun sélectionnés dans le groupe composé de N, NCH¿3??+¿, CH, et CR dans lequel R n'est pas hydrogène; et où au moins deux éléments parmi Y¿1?, Y¿2?, Y¿3? et Y¿4? ne représentent ni CH¿2?, ni CH, ni CR ni CR¿1?R¿2?.
CA002190379A 1994-05-16 1995-05-16 Adsorbants de chromatographie utilisant des ligands mercapto heterocycliques Expired - Fee Related CA2190379C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/243,861 US5502022A (en) 1994-05-16 1994-05-16 Chromatography adsorbents utilizing mercapto heterocyclic ligands
US08/243,861 1994-05-16
PCT/US1995/006014 WO1995031279A1 (fr) 1994-05-16 1995-05-16 Adsorbants de chromatographie utilisant des ligands mercapto heterocycliques

Publications (2)

Publication Number Publication Date
CA2190379A1 CA2190379A1 (fr) 1995-11-23
CA2190379C true CA2190379C (fr) 2005-10-25

Family

ID=35311645

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002190379A Expired - Fee Related CA2190379C (fr) 1994-05-16 1995-05-16 Adsorbants de chromatographie utilisant des ligands mercapto heterocycliques

Country Status (1)

Country Link
CA (1) CA2190379C (fr)

Also Published As

Publication number Publication date
CA2190379A1 (fr) 1995-11-23

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