CA2189435A1 - Dihydro ou tetrahydroporphyrines derivees du polyethyleneglycol, leur preparation et leur utilisation en tant que composes de photosensibilisation servant a localiser des tumeurs - Google Patents

Dihydro ou tetrahydroporphyrines derivees du polyethyleneglycol, leur preparation et leur utilisation en tant que composes de photosensibilisation servant a localiser des tumeurs

Info

Publication number
CA2189435A1
CA2189435A1 CA002189435A CA2189435A CA2189435A1 CA 2189435 A1 CA2189435 A1 CA 2189435A1 CA 002189435 A CA002189435 A CA 002189435A CA 2189435 A CA2189435 A CA 2189435A CA 2189435 A1 CA2189435 A1 CA 2189435A1
Authority
CA
Canada
Prior art keywords
compounds
tumour
group
derivatised
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002189435A
Other languages
English (en)
Inventor
David F. Horrobin
Brenda E. Reynolds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scotia Holdings PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2189435A1 publication Critical patent/CA2189435A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ces composés sont des dihydro ou tétrahydroporphorines dérivées du polyéthylèneglycol, acceptables sur le plan pharmacologique, servant à localiser des tumeurs et répondant aux formules (4), (5) et (6) dans lesquelles R?1¿¿n? peut représenter -OH mais, dans au moins deux cas, représente une chaîne de formule (-O-X¿p?-[CH¿2?CH¿2?O]¿m?-Y)¿n? dans laquelle n vaut 1 à 3, m vaut 5 à 250 et p vaut 0 à 1; le groupe Y peut représenter un groupe acyle ou alcoyle C¿1-12? mais représente, de préférence, un groupe méthyle; le groupe de liaison X peut être présent ou absent, mais s'il est présent, il peut représenter l'une des formes suivantes: R?2¿ = -(C=O)-(CH¿2?)¿q?-O- où q vaut 1 à 5, R?3¿ = -CH¿2?-CH(OH)-(CH¿2?)¿s?-O- où s vaut 1 à 4, R?4¿ = -(C=O)-(CH¿2?)¿t?-(C=O)-O- où t vaut 1 à 4. Ces composés de photosensibilisation à substitution polyéther permettent de mieux localiser les tumeurs grâce à leur pénétration plus efficace à l'intérieur des cellules tumorales. Des doses globalement inférieures de médicament permettent d'améliorer le profil d'effets secondaires du traitement, notamment en égard à la photosensibilisation de la peau.
CA002189435A 1994-05-03 1995-05-02 Dihydro ou tetrahydroporphyrines derivees du polyethyleneglycol, leur preparation et leur utilisation en tant que composes de photosensibilisation servant a localiser des tumeurs Abandoned CA2189435A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9408746.7 1994-05-03
GB9408746A GB9408746D0 (en) 1994-05-03 1994-05-03 Tumour locallising photosensitising compounds

Publications (1)

Publication Number Publication Date
CA2189435A1 true CA2189435A1 (fr) 1995-11-09

Family

ID=10754481

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002189435A Abandoned CA2189435A1 (fr) 1994-05-03 1995-05-02 Dihydro ou tetrahydroporphyrines derivees du polyethyleneglycol, leur preparation et leur utilisation en tant que composes de photosensibilisation servant a localiser des tumeurs

Country Status (11)

Country Link
EP (1) EP0758331A1 (fr)
JP (1) JPH09512544A (fr)
KR (1) KR970702862A (fr)
AU (1) AU2317295A (fr)
CA (1) CA2189435A1 (fr)
GB (1) GB9408746D0 (fr)
NO (1) NO964635L (fr)
NZ (1) NZ284552A (fr)
TW (1) TW397836B (fr)
WO (1) WO1995029915A1 (fr)
ZA (1) ZA953560B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362175B1 (en) * 1991-09-20 2002-03-26 The Trustees Of The University Of Pennsylvania Porphyrin compounds for imaging tissue oxygen
DE19514087A1 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforsch Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein
DE19627164C2 (de) * 1996-07-05 1998-09-24 Deutsches Krebsforsch Herstellung polyether-aufweisender Chlorine und Bakteriochlorine, solche Verbindungen und ihre Verwendung
ES2237146T3 (es) 1998-08-28 2005-07-16 Destiny Pharma Limited Derivados de porfirina, su uso en terapia fotodinamica y dispositivos medicos que los contienen.
GB0005855D0 (en) * 2000-03-10 2000-05-03 Scotia Holdings Plc Compounds for pdt
JP5000050B2 (ja) * 2001-08-31 2012-08-15 浩 前田 抗腫瘍剤及びその製造方法
CN108715591B (zh) * 2018-06-01 2021-04-13 华东理工大学 用作光敏剂的近红外吸收卟啉化合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8429845D0 (en) * 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment
GB8805849D0 (en) * 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
ATE115864T1 (de) * 1990-05-30 1995-01-15 Deutsches Krebsforsch Polyethersubstituierte tumormittel.

Also Published As

Publication number Publication date
WO1995029915A1 (fr) 1995-11-09
JPH09512544A (ja) 1997-12-16
NZ284552A (en) 1997-12-19
AU2317295A (en) 1995-11-29
NO964635D0 (no) 1996-11-01
TW397836B (en) 2000-07-11
NO964635L (no) 1996-11-01
KR970702862A (ko) 1997-06-10
ZA953560B (en) 1996-01-11
EP0758331A1 (fr) 1997-02-19
GB9408746D0 (en) 1994-06-22

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Legal Events

Date Code Title Description
FZDE Dead