CA2188529C - Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production - Google Patents
Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production Download PDFInfo
- Publication number
- CA2188529C CA2188529C CA002188529A CA2188529A CA2188529C CA 2188529 C CA2188529 C CA 2188529C CA 002188529 A CA002188529 A CA 002188529A CA 2188529 A CA2188529 A CA 2188529A CA 2188529 C CA2188529 C CA 2188529C
- Authority
- CA
- Canada
- Prior art keywords
- crystal
- aqueous solution
- process according
- frozen
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Cristal d'acide (1R, 5S, 6S)-6-[(1R)-1-hydroxyéthyl]-2-[(3S, 5S)-5-sulfamoylaminométhyl-1-pyrrolidin-3-yl]thio-1-méthyl-1-carba-2-penem-3-carboxylique représenté par la formule (I). Le procédé de production d'une préparation lyophilisée contenant les cristaux comprend l'étape de congélation d'une solution aqueuse du composé précité par refroidissement à -20 DEG C ou moins, l'étape de réchauffement de la solution congelée entre 0 et -10 DEG C, et l'étape de refroidissement et de réchauffement de la solution au moins deux fois dans la plage de températures comprise entre 0 et -10 DEG C.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6-93537 | 1994-05-02 | ||
| JP9353794 | 1994-05-02 | ||
| JP6-108554 | 1994-05-23 | ||
| JP10855494 | 1994-05-23 | ||
| PCT/JP1995/000858 WO1995029913A1 (fr) | 1994-05-02 | 1995-04-28 | Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2188529A1 CA2188529A1 (fr) | 1995-11-09 |
| CA2188529C true CA2188529C (fr) | 2005-12-06 |
Family
ID=35519669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002188529A Expired - Lifetime CA2188529C (fr) | 1994-05-02 | 1995-04-28 | Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2188529C (fr) |
-
1995
- 1995-04-28 CA CA002188529A patent/CA2188529C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2188529A1 (fr) | 1995-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20150428 |
|
| MKEX | Expiry |
Effective date: 20150428 |