CA2188529C - Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production - Google Patents

Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production Download PDF

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Publication number
CA2188529C
CA2188529C CA002188529A CA2188529A CA2188529C CA 2188529 C CA2188529 C CA 2188529C CA 002188529 A CA002188529 A CA 002188529A CA 2188529 A CA2188529 A CA 2188529A CA 2188529 C CA2188529 C CA 2188529C
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Prior art keywords
crystal
aqueous solution
process according
frozen
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002188529A
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English (en)
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CA2188529A1 (fr
Inventor
Masayoshi Inoue
Kazuichi Fujikane
Kenji Sugiyama
Hideaki Tai
Fumihiko Matsubara
Katsuo Oda
Takashi Oya
Yoshinori Hamada
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Priority claimed from PCT/JP1995/000858 external-priority patent/WO1995029913A1/fr
Publication of CA2188529A1 publication Critical patent/CA2188529A1/fr
Application granted granted Critical
Publication of CA2188529C publication Critical patent/CA2188529C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cristal d'acide (1R, 5S, 6S)-6-[(1R)-1-hydroxyéthyl]-2-[(3S, 5S)-5-sulfamoylaminométhyl-1-pyrrolidin-3-yl]thio-1-méthyl-1-carba-2-penem-3-carboxylique représenté par la formule (I). Le procédé de production d'une préparation lyophilisée contenant les cristaux comprend l'étape de congélation d'une solution aqueuse du composé précité par refroidissement à -20 DEG C ou moins, l'étape de réchauffement de la solution congelée entre 0 et -10 DEG C, et l'étape de refroidissement et de réchauffement de la solution au moins deux fois dans la plage de températures comprise entre 0 et -10 DEG C.
CA002188529A 1994-05-02 1995-04-28 Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production Expired - Lifetime CA2188529C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP9353794 1994-05-02
JP6-93537 1994-05-02
JP6-108554 1994-05-23
JP10855494 1994-05-23
PCT/JP1995/000858 WO1995029913A1 (fr) 1994-05-02 1995-04-28 Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production

Publications (2)

Publication Number Publication Date
CA2188529A1 CA2188529A1 (fr) 1995-11-09
CA2188529C true CA2188529C (fr) 2005-12-06

Family

ID=35519669

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CA002188529A Expired - Lifetime CA2188529C (fr) 1994-05-02 1995-04-28 Cristal de derive de pyrrolidylthiocarbapeneme, preparation lyophilisee le contenant et son procede de production

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CA (1) CA2188529C (fr)

Also Published As

Publication number Publication date
CA2188529A1 (fr) 1995-11-09

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