CA2188452C - Composes substitues par guanidino - Google Patents

Composes substitues par guanidino Download PDF

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Publication number
CA2188452C
CA2188452C CA002188452A CA2188452A CA2188452C CA 2188452 C CA2188452 C CA 2188452C CA 002188452 A CA002188452 A CA 002188452A CA 2188452 A CA2188452 A CA 2188452A CA 2188452 C CA2188452 C CA 2188452C
Authority
CA
Canada
Prior art keywords
compound
propylguanidine
dideoxy
erythro
hexoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002188452A
Other languages
English (en)
Other versions
CA2188452A1 (fr
Inventor
Sumanas Rakhit
Abdelmalik Slassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allelix Biopharmaceuticals Inc
Original Assignee
Allelix Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allelix Biopharmaceuticals Inc filed Critical Allelix Biopharmaceuticals Inc
Publication of CA2188452A1 publication Critical patent/CA2188452A1/fr
Application granted granted Critical
Publication of CA2188452C publication Critical patent/CA2188452C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nouveaux composés substitués par guanidino correspondant à la formule générale (I), ou leur sel, hydrate ou solvate. Dans cette formule, X est choisi entre C, O, N et S; R¿1? et R¿3? représentent indépendamment -(W)¿a?-(R¿6?)¿b?-Z, où a et b valent séparément 0 ou 1; W représente NH, O ou S; R¿6? représente alkylène C¿1-8? dont un ou deux atomes de carbone intermédiaires et non adjacents sont éventuellement remplacés par azote ou oxygène; et Z représente H, OH ou -NH-C(NH)-NH¿2?, à condition que Z représente H quand b vaut 0; R¿2? est choisi entre H et OH; et R¿4? et R¿5? représentent indépendamment alkylène C¿1-8? dont un des atomes de carbone est éventuellement remplacé par azote ou oxygène. Des composés conformes à la formule (I) inhibent la réplication du VIH.
CA002188452A 1994-04-28 1995-04-28 Composes substitues par guanidino Expired - Fee Related CA2188452C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23412194A 1994-04-28 1994-04-28
US08/234,121 1994-04-28
PCT/CA1995/000250 WO1995029926A1 (fr) 1994-04-28 1995-04-28 Composes substitues par guanidino

Publications (2)

Publication Number Publication Date
CA2188452A1 CA2188452A1 (fr) 1995-11-09
CA2188452C true CA2188452C (fr) 2000-12-05

Family

ID=22880020

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002188452A Expired - Fee Related CA2188452C (fr) 1994-04-28 1995-04-28 Composes substitues par guanidino

Country Status (4)

Country Link
EP (1) EP0757695A1 (fr)
AU (1) AU2301295A (fr)
CA (1) CA2188452C (fr)
WO (1) WO1995029926A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6525182B1 (en) * 2000-01-21 2003-02-25 Regents Of The University Of California Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032420A1 (fr) * 1989-12-22 1991-06-23 Akira Okuyama Derives de la phenylguanidine
US5627194A (en) * 1993-11-17 1997-05-06 Allelix Biopharmaceuticals Inc. Anti-viral guanidino-substituted compounds

Also Published As

Publication number Publication date
EP0757695A1 (fr) 1997-02-12
CA2188452A1 (fr) 1995-11-09
WO1995029926A1 (fr) 1995-11-09
AU2301295A (en) 1995-11-29

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